4FRW


Conserved Protein Domain Family
IgC1_2_Nectin-3-4_like

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cd07704: IgC1_2_Nectin-3-4_like 
Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the second immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 or cluster of differentiation (CD) 113) and nectin-4 (poliovirus receptor related protein 4). Nectin-3 and nectin-4 belong to the nectin family comprised of four transmembrane glycoproteins (nectin-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. Nectin-3 has also been shown to form a heterophilic trans-interaction with nectin-1 in ciliary epithelia, establishing the apex-apex adhesion between the pigment and non-pigment cell layers. Nectin-4 has recently been identified in several types of breast carcinoma and can be used as a histological and serological marker for breast cancer.
Statistics
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PSSM-Id: 409501
Aligned: 6 rows
Threshold Bit Score: 147.273
Created: 3-May-2009
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #######                                                                         
4FRW_A    118 PLPSLNPGpale-egqgLTLAASCTAE-GSPAPSVTWDTEVKGTTSSRSFKHSr-SAAVTSEFHLVPSRSMNGQPLTCVV 194 human
Q5FWR8    147 PLPTLGPGpplt-egegKSLAASCTAE-GNPAPTLTWETDVEGTNTTQKYEHPr-SSSVTSEFYVVPTRRMNGKPLTCVV 223 western clawed frog
CAM73163  151 PKVYVSAGssalidggnETTVATCIAErARPPADVSWETNLYGMSEAHMQEDAngTTTTQVHYIWQPSRHAQGHTLTCVV 230 zebrafish
XP_416630 176 PVVSLTKGpnplidganQTIAAICTAAtGKPAAEIDWEGGLGEMESSSTLFPNe-TVTVISQYTIIPTRFARGRRITCIV 254 chicken
Q96NY8    149 PLPSLNPGpale-egqgLTLAASCTAE-GSPAPSVTWDTEVKGTTSSRSFKHSr-SAAVTSEFHLVPSRSMNGQPLTCVV 225 human
Q9NQS3    170 PTVSLIKGpdslidggnETVAAICIAAtGKPVAHIDWEGDLGEMESTTTSFPNe-TATIISQYKLFPTRFARGRRITCVV 248 human
Feature 1                      
4FRW_A    195 SHPGLLQDQRITHILHV 211 human
Q5FWR8    224 SHPGFQQEKRITHVLQV 240 western clawed frog
CAM73163  231 KHPALQSDFRIPYIINV 247 zebrafish
XP_416630 255 RHPALEKEIRFSHVLDI 271 chicken
Q96NY8    226 SHPGLLQDQRITHILHV 242 human
Q9NQS3    249 KHPALEKDIRYSFILDI 265 human

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