5T89,5T89


Conserved Protein Domain Family
IgI_VEGFR-1

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cd07702: IgI_VEGFR-1 
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1); member of the I-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 1 (VEGFR-1). VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGFR-1 binds VEGF-A strongly; VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-1 may play an inhibitory role in the function of VEGFR-2 by binding VEGF-A and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis and may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.
Statistics
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PSSM-Id: 409499
View PSSM: cd07702
Aligned: 5 rows
Threshold Bit Score: 180.459
Threshold Setting Gi: 147899424
Created: 15-Nov-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig strand A [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #####                                                                           
5T89_X        307 FITVKhrkqqVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAteksaRYLTRgYSLIIKDVTEEDAGNYTILLSIKQS 386  human
5T89_Y        307 FITVKhrkqqVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAteksaRYLTRgYSLIIKDVTEEDAGNYTILLSIKQS 386  human
NP_001014829  325 FIRLKhrngpVVQAFAGQKSFRLTPKLKAFPAPEIIWLKDGMVAaercsRYHVDgFSLVIRDVAEEDAGIYTILTGIQQY 404  zebrafish
P17948        333 FITVKhrkqqVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPAteksaRYLTRgYSLIIKDVTEEDAGNYTILLSIKQS 412  human
NP_001079856  319 FINVKprtqgVLESFAGQKSYHILVKVRAFPDPEVIWLKDGLPAvekctRYSDK-YSLTIKDVTEEDAGKYTIVLQLKQW 397  African clawe...
Feature 1                     
5T89_X        387 NVFKNLTATLIV 398  human
5T89_Y        387 NVFKNLTATLIV 398  human
NP_001014829  405 GLFQNLTITLVV 416  zebrafish
P17948        413 NVFKNLTATLIV 424  human
NP_001079856  398 NLTKNLTLPLIV 409  African clawed frog

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