1A1M,1PQZ,1HYR,3VJ6,1N59,1KJV,1QO3,1T7V,1AKJ,1NEZ,5VCL,5IUE,2D31,1EXU,1K8D,1BZ9,1C16,1DE4,1A9E,1EFX,3BZF,4NT6,1N5A,6E1I


Conserved Protein Domain Family
IgC1_MHC_I_alpha3

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cd07698: IgC1_MHC_I_alpha3 
Class I major histocompatibility complex (MHC) alpha chain, alpha3 immunoglobulin domain; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig) domain of major histocompatibility complex (MHC) class I alpha chain. Class I MHC proteins bind antigenic peptide fragments and present them to CD8+ T lymphocytes. Class I molecules consist of a transmembrane alpha chain and a small chain called the beta-2-microglobulin. The alpha chain contains three extracellular domains, two of which fold together to form the peptide-binding cleft (alpha1 and alpha2), and one which has an Ig fold (alpha3). Peptide binding to class I molecules occurs in the endoplasmic reticulum (ER) and involves both chaperones and dedicated factors to assist in peptide loading. Class I MHC molecules are expressed on most nucleated cells.
Statistics
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PSSM-Id: 409495
View PSSM: cd07698
Aligned: 115 rows
Threshold Bit Score: 102.308
Threshold Setting Gi: 50513308
Created: 17-Oct-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1A1M; human MHC class I alpha3 domain forms dimer with beta2 microglobulin, defined using 3.5 A contacts
    View structure with Cn3D
  • Citation:PMID 8624812
  • Structure:1N5A; muring MHC class I alpha3 domain forms dimer with beta2 microglobulin, defined using 3.5 A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                            # #                          ## ###     # #                 
1A1M_A       183 DPPKTHVTHHpvs-dhEATLRCWALGFYPAEITLTWQRDGEDQtqdTELVETRPAGDRTFQKWAAVVVPSGEEQ--RYTC 259 human
AAF15304     204 VGPETKIFRKrrh-dgKYTFSCHASEFFPSALSIKWINIKTNEk-kEETAEALPNNDGTFQAWVDIDSDLECAR--DLVC 279 marbled lungfish
XP_007492726 200 EAPEVRAGGHpgpgdaQSTLTCQAFSFFPPEVKLTFLREGKPVpepEKGAEPWPNRDGAFHSQATLQVQRGDEA--RYSC 277 gray short-tail...
ABV02002      18 EAPEVRAGGHvesgstQSILTCQAFSFFPPELELSFLWKGQPVa--AKGVEPWPNGGGAFYSRGTLLVPFGDEA--LYSC 93  tammar wallaby
XP_020859000 203 EAPEVRVGGHvgpgstWSTLTCQAFSFFPPELKLTFLREGKPEsehAKGVEPWPNGDGAFHSRGTLMVPFGDEA--LYSC 280 koala
XP_012401301 201 EAPEVRAGSHvgpgavWSTLSCQAFFFFPPELELKFFREGKPVaelSPGLEPWPNGDGTFHSRGTLQVPSGDEA--LYSC 278 Tasmanian devil
AAG28391     210 EAPEVRAGGHvepgsaWSTLTCQAFSFFPPELELTFLREGQPQl--VKGVEPWPNRDGAFYSRGTLLVPFGDEA--FYSC 285 common brushtail
AAD08650     205 VPPTASVFQEee---sSPEVVCHATGFFPKTVMITWQKDGEDVhedVELRETLPNQDGTFQKRSILTVSAEDLQkhTYTC 281 channel catfish
CAD58766     197 VSPQVSLLQKs----sSSPVVCHATGFYPSGIKISWQKNGQDHdedVELEELLPNEDGTFQKSSTLTVTPEEWKnnKFRC 272 zebrafish
XP_001336749 195 RDPEVFLLQKn----pSSPVECFATGFYPSGVIITWLKNGQDHgenVELRELKPNEDGTFQRSSSLHVSQEDWKksLYTC 270 zebrafish
Feature 1                          
1A1M_A       260 HVQHEGlp---kPLTLRW 274 human
AAF15304     280 MITHGNss---eEHRIPA 294 marbled lungfish
XP_007492726 278 EVRHPAla---tPLTVSF 292 gray short-tailed opossum
ABV02002      94 VVQHPAla---sSITVNF 108 tammar wallaby
XP_020859000 281 MVQHPAla---rAITVNF 295 koala
XP_012401301 279 TVQHPAlt---eSITVNF 293 Tasmanian devil
AAG28391     286 LVQHPAla---sSITVNF 300 common brushtail
AAD08650     282 VIQHSSle---kEMVLPV 296 channel catfish
CAD58766     273 VVEHQGkt--ktEKEIRT 288 zebrafish
XP_001336749 271 VVEHQRmtiqksGDEIKS 288 zebrafish

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