1WIO


Conserved Protein Domain Family
IgV_3_CD4

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cd07695: IgV_3_CD4 
Third immunoglobulin (Ig) Variable (V) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains
The members here are composed of the third immunoglobulin variable (IgV) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.
Statistics
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PSSM-Id: 409492
View PSSM: cd07695
Aligned: 6 rows
Threshold Bit Score: 123.929
Threshold Setting Gi: 627760982
Created: 5-Jun-2009
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig4 domain interface [polypeptide binding site]
Evidence:
  • Structure:1WIO; human CD4 Ig3 domain forms an interchain interface with the Ig4 domain, defined using 4.0 A contacts
    View structure with Cn3D
  • Citation:PMID 9168119

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #### #                                                                      
1WIO_A    183 SSIVYKKEGEQVEFSFPLAFTVEK---LTGSGELWWQAERASSsKSWITFDLKnkEVSVKRVTQd---pKLQMGKkl-pL 255 human
ABR22561  216 SQTFYTMVGKAVRFSFPLNLNDQElnrEQPNGELRWNMEGTAS-PQVVKFSWK--SDSLTRGTDa---pPFNRDPkf-pL 288 tammar wallaby
ABX56472  208 SSIVYKKEGEQVEFSFPLAFTVEK---LTGSGELWWQAERASSsKSWITFDLKnkEVSVKRVTQd---pKLQMGKkl-pL 280 Pan troglodytes
AHY35169  208 SCIVYKKEGEQGEFSFPLAFTVEK---LPGSGELWWQAERASSsKSWITFYLKnkEVSVKRVTQd---hKLQMGKkl-pL 280 Gorilla gorilla
AXC25036  208 SSTVYKKEGEQVEFSFPLAFTLEK---LTGSGELWWQAERASSsKSWITFDLKnkEVSVKRVTQd---pKLQMGKkl-pL 280 Macaca mulatta
AAS67020  225 LEIIYTTVGNTAILSWRLNFRKIKw-kEGFTGKLNWEPQGNTAiHELLNFSVTthQELHKTKKSnhiwfEISEGKtdgtM 303 chicken
Feature 1                ##                     
1WIO_A    256 HLTLPQALPQYAGSGNLTLALEakTGKLHQEVNL 289 human
ABR22561  289 TITLSSVSPSHAGSGVFLLQFS--SGTVEQKVNL 320 tammar wallaby
ABX56472  281 HLTLPQALPQYAGSGNLTLALEakTGKLHQEVNL 314 Pan troglodytes
AHY35169  281 LLTLPQALPQYAGSGNLTLALEakTGKLHQEVNL 314 Gorilla gorilla
AXC25036  281 HLTLPQALPQYAGSGNLTLALEakTGKLHQEVNL 314 Macaca mulatta
AAS67020  304 DVKIPKVQLNHSGQYKCQLEIN--GRRTESVRAL 335 chicken

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