1WIO


Conserved Protein Domain Family
IgC2_2_CD4

?
cd07694: IgC2_2_CD4 
Second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the C2-set of IgSF domains
The members here are composed of the second immunoglobulin (Ig) Constant 2 (C2)-set domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.
Statistics
?
PSSM-Id: 409491
View PSSM: cd07694
Aligned: 3 rows
Threshold Bit Score: 123.948
Threshold Setting Gi: 2392606
Created: 26-May-2009
Updated: 17-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:Ig1 domain interface [polypeptide binding site]
Evidence:
  • Structure:1WIO; human CD4 Ig2 domain forms an interchain interface with the Ig1 domain, defined using 4.0 A contacts
    View structure with Cn3D
  • Citation:PMID 8075984

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1     #                    # #                                                        
1WIO_A     98 FGLTANSDTHLLQGQSLTLTLESPpg-ssPSVQCRSPRGKNIQGG-----------KTLSVSQLELQDSGTWTCTVLqn- 164 human
ABR22561  126 FKVTATPSDYVISGTNVTLTLHGSsn--lPAFKVEWRGPGDKSKQiln-----qdkKTLNLVKMGPNETGLWDCIVSv-- 196 tammar wallaby
AAS67020  125 FKLTISSNGHFLTNEDLELTLMQNsshsqPHLSIKLFNINNDIVTteilqeeapqkYILKLKQLKAIDSGTWMCHVYsns 204 chicken
Feature 1        ####         
1WIO_A    165 -qkKVEFKIDIVVLAF 179 human
ABR22561  197 --sEKTLKLGIKVTAF 210 tammar wallaby
AAS67020  205 psiNQNISFDVKVLGF 220 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap