1XIW


Conserved Protein Domain Family
IgC1_CD3_epsilon

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cd07692: IgC1_CD3_epsilon 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain; member of the C1-set of IgSF domains
The members here are composed of the immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 epsilon chain. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.
Statistics
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PSSM-Id: 409489
View PSSM: cd07692
Aligned: 3 rows
Threshold Bit Score: 123.152
Threshold Setting Gi: 50979254
Created: 29-Oct-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1XIW; human CD3 epsilon chain forms a heterodimer interface with CD3 delta chain, defined using 3.5 A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #   #                                                        #               ###
1XIW_A        15 YKVSISGTTVILTCpqy-pgsEILWQhndKNIggdeddkniGSDE-DHLSLKEFSELEQSGYYVCYPrgskpedANFYLY 92  human
NP_001003379  41 FKVSISGTEVVVTCpdvfgydNIKWEkndNLV---------EGASnRELSQKEFSEVDDSGYYACYAds---ikEKSYLY 108 dog
P29328        30 YEVSISGNSVELTCpkd-fenGIQWKr--NNEq-------mKGHNeKYLLLDQFSEMESSGYYQCLAteg-nteAAHTLY 98  sheep
Feature 1         ###
1XIW_A        93 LRAR 96  human
NP_001003379 109 LRAR 112 dog
P29328        99 LKAR 102 sheep

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