1XIW


Conserved Protein Domain Family
IgC1_CD3_gamma_delta

?
cd07691: IgC1_CD3_gamma_delta 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains
The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.
Statistics
?
PSSM-Id: 409488
View PSSM: cd07691
Aligned: 5 rows
Threshold Bit Score: 98.7653
Threshold Setting Gi: 195539990
Created: 29-Oct-2008
Updated: 17-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1XIW; human CD3 delta chain forms a heterodimer interface with CD3 epsilon chain, defined using 3.5 A contacts.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1     ## #                                                 #              ### ##### 
1XIW_B      4 PIEELedRVFVNCn------tSITWVEGTVGTLLSd--iTRLDLGKRILDPRGIYRCNGtdiykdKESTVQVHYRMCQ 73  human
CAB62062   29 SVKEVsgKVFLQCqeskdlntNYLWKKGKEELGNM----RQLDLGAIYDDPRGTYTCQRde---nVNSTLHVHYRMCQ 99  chicken
CAA37182   25 EVLEAedKVILKCn------sSITLLQGTAGQEVSd--nKTLNLGKRIEDPRGMYQCGEn----aKSFTLQVYYRMCQ 90  sheep
AAI13831   35 DYQEDg-SVLLTCdae---akNITWFKDGKMIGFLtedkKKWNLGSNAKDPRGMYQCKGsq---nKSKPLQVYYRMCQ 105 human
AAI68039   27 SVKNN--YLTLKCns----asSVIWKHNNEIIEANn---TDLDLGSLWNDPRGTYSCKAse--neNEKSIEVFVRMCQ 93  western clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap