1CDI,1JL4,1RZJ,1WIO


Conserved Protein Domain Family
IgV_1_CD4

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cd07690: IgV_1_CD4 
First immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4; member of the V-set of IgSF domains
The members here are composed of the first immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 4. CD4 and CD8 are the two primary co-receptor proteins found on the surface of T cells, and the presence of either CD4 or CD8 determines the function of the T cell. CD4 is found on helper T cells, where it is required for the binding of MHC (major histocompatibility complex) class II molecules, while CD8 is found on cytotoxic T cells, where it is required for the binding of MHC class I molecules. CD4 contains four immunoglobulin domains, with the first three included in this hierarchy. The fourth domain has a general Ig architecture, but has slight topological changes in the arrangement of beta strands relative to the other structures in this family and is not specifically included in the hierarchy.
Statistics
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PSSM-Id: 409487
View PSSM: cd07690
Aligned: 7 rows
Threshold Bit Score: 167.725
Threshold Setting Gi: 77403679
Created: 24-Oct-2008
Updated: 17-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:MHC interface [polypeptide binding site]
Evidence:
  • Structure:1JL4_D; human CD4 interacts with major histocompatibility complex (MHC) class II beta chain, defined using 4.0 A contacts
    View structure with Cn3D
  • Structure:1RZJ_C; human CD4 interacts with the HIV-1 protein gp120, defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #### #           #                   
1CDI_A      2 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSnQIKILGNqg-sFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDS 80  human
1JL4_D      1 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSnQIKILGNqg-sFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDS 79  human
1RZJ_C      1 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSnQIKILGNqg-sFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDS 79  human
1WIO_A      1 KKVVLGKKGDTVELTCTASQKKSIQFHWKNSnQIKILGNqg-sFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDS 79  human
BAE46418   26 KEVVLGKAGDKAELPCQASQKKNMKFSWKYS-GIKVLENfpgsYKMLGTAVQSTRSDSSRNLWEQGSFPLIIRNLDIKDS 104 Egyptian rousette
EDM01911   28 KTVVLGKEGGSAELPCESTSRRSASFAWKSSdQKTILGYkn-kLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDS 106 Norway rat
AAD23738   26 KKVVLGKAGELAELPCKASQNKSLFFSWKNSyQTKILGRhg-yFWHKGASNLHSRVESKINLWDQGSFPLVIKDLEVPDS 104 beluga whale
Feature 1                       
1CDI_A     81 DTYICEVEDQKEEVQLLV 98  human
1JL4_D     80 DTYICEVEDQKEEVQLLV 97  human
1RZJ_C     80 DTYICEVEDQKEEVQLLV 97  human
1WIO_A     80 DTYICEVEDQKEEVQLLV 97  human
BAE46418  105 GIYTCDVEDKKREVELLV 122 Egyptian rousette
EDM01911  107 QTYVCELENKKEEVELWV 124 Norway rat
AAD23738  105 GTYICEVEDKKIEVELQV 122 beluga whale

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