Conserved Protein Domain Family
F-BAR_PSTPIP1

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cd07671: F-BAR_PSTPIP1 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 1
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Proline-Serine-Threonine Phosphatase-Interacting Protein 1 (PSTPIP1), also known as CD2 Binding Protein 1 (CD2BP1), is mainly expressed in hematopoietic cells. It is a binding partner of the cell surface receptor CD2 and PTP-PEST, a tyrosine phosphatase which functions in cell motility and Rac1 regulation. It also plays a role in the activation of the Wiskott-Aldrich syndrome protein (WASP), which couples actin rearrangement and T cell activation. Mutations in the gene encoding PSTPIP1 cause the autoinflammatory disorder known as PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. PSTPIP1 contains an N-terminal F-BAR domain, PEST motifs, and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153355
View PSSM: cd07671
Aligned: 4 rows
Threshold Bit Score: 436.699
Threshold Setting Gi: 76363554
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #      #  ##  #  ##  ##  #   #  #   #                      #  #         
P97814        16 FTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKAGGQtemnslrtsFDSLKQQTENVGSAHIQLA 95  house mouse
NP_001087785  15 ITLNTGYEILLQRLLDGRKMCKDVEDLLKQRAQAEEKYGKELVQIAKKAGGQteinklwksFKTLKKQIENIGNSHIQLA 94  African clawed ...
XP_413733     44 FTLHTGFEVLVQRLLDGRKMCKDVEDLLKQRAQAEERYGKELVQIARKAGGQtevntlkaaFEKLKQQIESVGNSHIQLA 123 chicken
NP_001038681  15 FTSNSGYEILIQRLCDGRRACKDMEELLKMRAMAEERYGKELITIARKTGGQteigtlkasFDQLKAQMENIGNLHIQLS 94  zebrafish
Feature 1                                                                                        
P97814        96 LALREELRSLEEFRERQKEQRKKYEAIMDRVQKSKLSLYKKTMESKKAYDQKCRDADdaeqafer--vsanghqKQVEKS 173 house mouse
NP_001087785  95 VTLREEIRSLEEFRERQKEIRKKYENSMEHLQKKKVSLYKKTMDSKKSYEQRCQEAKeaeqnhgr--lvslgnpKQIEKS 172 African clawed ...
XP_413733    124 GMLKDELKGIEEFRERQKEQRKKYEAAMERMQKSKLSHYKKTMESKKNYEQKCKEADeaeqsfer--msasgnqKQTEKS 201 chicken
NP_001038681  95 GMLREEAKRMEHFRERQKEQRKKFEGVMEKVQKIKVSLYKKTMESKRTYEQRCREADeaeltaeklnststvtpKQSEKT 174 zebrafish
Feature 1                      #   #                        #   #  #  ##  #   #  #   #   #  ##  #
P97814       174 QNKAKQCKeSATEAERVYRQNIEQLERARTEWEQEHRTTCEAFQLQEFDRLTILRNALWVHCNQLSMQCVKDDELYEEVR 253 house mouse
NP_001087785 173 QNKAKHCReDAEEADRLYKNNIDFLDKARIEWETEHINTCQAFQLQEIDRISILRNSLWVQCNHFSSQCVHDDELMEEVR 252 African clawed ...
XP_413733    202 QNKAKQCRdAAHEAENVYKQNIEQLDKARTEWEEAHIKTCEVFQLQECDRITILRNSLWVHCNQLSMQCVKDDEQYEEVR 281 chicken
NP_001038681 175 QNKAKQCRdAATDAEKQYISNIEQLDKIRQEWETTHELTCEVFQQQEDDRINILRNAIWVHCNHFSMQCVKEDECYEEVR 254 zebrafish
Feature 1            
P97814       254 LTLE 257 house mouse
NP_001087785 253 QTLE 256 African clawed frog
XP_413733    282 VSLE 285 chicken
NP_001038681 255 TTLE 258 zebrafish

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