Conserved Protein Domain Family
BAR_PICK1

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cd07659: BAR_PICK1 
The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
The BAR domain of Arfaptin-like proteins, also called the Arfaptin domain, is a dimerization and lipid binding module that can detect and drive membrane curvature. Protein Interacting with C Kinase 1 (PICK1), also called Protein kinase C-alpha-binding protein, is highly expressed in brain and testes. PICK1 plays a key role in the trafficking of AMPA receptors, which are critical for regulating synaptic strength and may be important in cellular processes involved in learning and memory. PICK1 is also critical in the early stages of spermiogenesis. Mice deficient in PICK1 are infertile and show characteristics of the human disease globozoospermia such as round-headed sperm, reduced sperm count, and severely impaired sperm motility. PICK1 may also be involved in the neuropathogenesis of schizophrenia. PICK1 contains an N-terminal PDZ domain and a C-terminal BAR domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of PICK1 is necessary for its membrane localization and activation.
Statistics
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PSSM-Id: 153343
View PSSM: cd07659
Aligned: 15 rows
Threshold Bit Score: 313.493
Threshold Setting Gi: 167525831
Created: 12-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interfaceputative Rac
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the dimer structure of human Arfaptin 2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        ##     #   #  #  ##  #  ##   # ##  #  ##    ## ##  #   #        
Q62083       146 NDGLVKRLEELERTAELYKGMTEHTKNLLRAFYDVSQTHRAFGDVFSVIGVRDAQPaasEAFVKFADAHRSIEKFGIRLL 225 house mouse
EEB12464     131 NDTLVKKLEELESTEMMYQGLVEHTKRVMKAFFQLLQVYKAFGDAFAGIGVREPQPrasEAFRQFGDYHRQMEKYGLQML 210 human body louse
XP_788322    142 NDVLIKRLDELNKTSRLYKGLMDHTKKLLKIFYEMSSTHRAFGDIFCLIGAREIQPkasDAFTKFGDAHRNMEKFGIRLL 221 purple urchin
XP_001630160 143 NDGLVKKLDELEQNANVYKGLLDHARQYLHSFYQLSQTHKELGDIFASIGVRELQPnasEAFAIFSEAHRQFDRHGMDFL 222 starlet sea ane...
XP_002132162 143 NDILIKRLQDLERTGMVYVGLMEHVKKLLKAYFNLCKTHREFGDIFSIIGVREPHPnggEAFLKFSSSHREFEKSGFTLL 222 Ciona intestinalis
XP_002109696 138 NDTLVKRLEELQQNSSIYLGLIERARAMMKSTAKLIAAHKAFGEAFAAIGVKEPQAnasLAFSRFGEAHRNLERFGTQLL 217 Trichoplax adha...
XP_969517    147 NDTLVKKLQELQHTELMYRGLVDHSKRVLQAHVELQQAIKAMGDVFAGLAVREPQPrasEAFRVFGEQHRSMEKFGQDMV 226 red flour beetle
XP_001943674 149 NDSLVKRLQQLDDMEQSYRHLVDHTERVLRAFYALTQCFKEFGDTFAEIGAREPQPrasEALVRFAEYHRRMERQGLMLI 228 pea aphid
XP_001898398 138 NDLLLQKLNRLEQCSQLYKKLIKHLSALLNSHYHIAKTQKEFGDLFCQIAARESSTttnKALLTFGNMHRTIEKHTVKLV 217 agent of lympha...
NP_723766    131 NDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQISVHEPQQrasEAFRTFGEFHRTLEKDGLGII 210 fruit fly
Feature 1                                                                                        
Q62083       226 KTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEysciaarralYRVSTGNYEYRLILRCRQEAR 305 house mouse
EEB12464     211 KTVKPMLSDLGTYLHKAIPDTKLTINKYADTKFEYLSYCLKVKEMDDEEysygilqeplYRVETGNYEYRLILRCRQEAR 290 human body louse
XP_788322    222 RTVKPMLSDLGTFLTKAIPDTKLTIKKYADTKFEYLSYCLKVKEMDDEEyayatlgeplYRVETGNYEYRLILRCRQEAR 301 purple urchin
XP_001630160 223 KKVKPTLSDLNTYLSKAIPDTRLTIRKYADAKFEYLSYCLKVKEMDDEEyayaalheslYRVETGNYDYRVVLRCRQLAR 302 starlet sea ane...
XP_002132162 223 KTLKPMLNDLNTYLNKAIPDTKLTIKKYADVKFEYLSFCLKVKELDDEEysyaalqeplYRVETGNYEYRLVLRCRQQAR 302 Ciona intestinalis
XP_002109696 218 RNIAPIVTDLMTYLSKAIPDTRLTIKKYADVKFEYLAYCLKVKEMDDEEygyaamheslYRVETGNYEYRLVLRCRHDAR 297 Trichoplax adha...
XP_969517    227 KKVKPVLADMGTYLYKAIPDTRLTVKKYADAKFEYLAYCLKVKEMDDEEcsyaalqeplYRVETGNYEYRLILRCRQLAR 306 red flour beetle
XP_001943674 229 KALKPISRSFGTYLNKAIPDTKQTIRKYADVKFEYLSYCLKVKELDDEEitycsadeplYRIETGNYEYRLVLRCRQLAR 308 pea aphid
XP_001898398 218 KSLHPIVRDLKTFVEKAIPDTKLTLKKYLDAKFEYLAFCLKLKEMDDEEveaasydeplYRVETGNYEYRLMLRCRQNSH 297 agent of lympha...
NP_723766    211 KQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKEMDDEEhgfaalqeplYRVETGNYEYRLILRCRQDAR 290 fruit fly
Feature 1                            #   ##  ## ##      ## ##                 
Q62083       306 ARFSQMRKDVLEKMELLDQKHVqdIVFQLQRFVSTMSKYYNDCYAV------LQDADVFPI 360 house mouse
EEB12464     291 ARFARLRSDVLVKLELLDNKHVqdIVIQLQKMVTGLADFYSKSLQL------LKENSLFPV 345 human body louse
XP_788322    302 ARFAKLRSDVMVKMELLDQKHVqdIVFQLHRLVSAMTQYLQDCHQQ------MKNTDLFPI 356 purple urchin
XP_001630160 303 EKFAKLRSDVLVKLELLDQKHVqdIVFQLQRFVSAVAGYHDDAYGI------LKEANVFPI 357 starlet sea anemone
XP_002132162 303 AQFAKLRKDVMEKLELLDNKHVqdIVFQLQRFVSAVSQYHESCHES------MQSADVFPI 357 Ciona intestinalis
XP_002109696 298 VRFAKLRQDVMVKLELLDHKHVqdLCTQLRRLIGSLTEYHQDCIKE------MEETDIFPI 352 Trichoplax adhaerens
XP_969517    307 ARFAKLRSDVLVKMELLDNKHVqsLGGHLTKLIKGLSEVHSKSLEL------LSGPALFPV 361 red flour beetle
XP_001943674 309 KRFAALREDVLAKIELLENKHVhdVVGQLHAIASQMASYNREISWMmlggnnVSEPPLFPI 369 pea aphid
XP_001898398 298 EKFMKLRRDVMEKLELLDQKHVqdIGIXLSSFVKAIMETHAECRDAi-----SGANGLFPI 353 agent of lymphatic filariasis
NP_723766    291 SKFAKLRTDVLEKMELLECKHAmdLNKQLRSLLESLAELHRSLVDRl-----DSLPPLFPI 346 fruit fly

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