Conserved Protein Domain Family
F-BAR_NOSTRIN

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cd07658: F-BAR_NOSTRIN 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase TRaffic INducer (NOSTRIN)
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Nitric Oxide Synthase TRaffic INducer (NOSTRIN) is expressed in endothelial and epithelial cells and is involved in the regulation, trafficking and targeting of endothelial NOS (eNOS). NOSTRIN facilitates the endocytosis of eNOS by coordinating the functions of dynamin and the Wiskott-Aldrich syndrome protein (WASP). Increased expression of NOSTRIN may be correlated to preeclampsia. NOSTRIN contains an N-terminal F-BAR domain and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. The F-BAR domain of NOSTRIN is necessary and sufficient for its membrane association and is responsible for its subcellular localization.
Statistics
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PSSM-Id: 153342
View PSSM: cd07658
Aligned: 11 rows
Threshold Bit Score: 275.414
Threshold Setting Gi: 25145403
Created: 17-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #  #      #  ##  #  ##  ##  #   #  #   #                         #  #      
Q6WKZ7          8 CSYNKVYKSLKEFAQHGDNFCKQITSVLQQRANLEISYAKGLQKLAVRLSKalqstkknclstaWAWASESMKSAADLHQ 87   house mouse
XP_002217370    8 FMGHFGYDELKRHMRQAKEFCNEIGTVLHERAELEQAYAKGLSKLSTKLAKavnttg-gtlmttWTCVATEMELEAEMHR 86   Florida lancelet
XP_001635935    8 FWEQKGYEELRKSCRQGSDFCKEIAAIFNERSKIELSYADSLSKLSVKAQKllakdvvgtlkssWEKISWNIESEADIHR 87   starlet sea a...
ACI03580      558 DEGQNGFEELRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKagreip-gsvadaWRGVATEMESRSDIHR 636  fruit fly
XP_002120023    8 FMGTVGFEEIKRYTRQGTEFCREIVNILNERAMLEQNYAKSLRRLGQRMSKaacsvlgspmsssWKTVGVETEKEAELHR 87   Ciona intesti...
NP_497805      47 FATPSNFRQLRDLIRNNNELLAEVVTAFEEKAALDFHYSKTLKKISIRLHKltqsve-sgidkgWTNVAEQFDIHATIHS 125  nematode
XP_001599805  424 ESGPGGFEEVRRYVKQGGDFCKELAAILHERAELEANYAKGLSKLSGKLTKacgngs-ggvseaWRCVGEEMEAAAEAHR 502  jewel wasp
NP_001107076    8 CTYNLLYQELKRISKNGEFFCKELLAVFQQRSELEINYSKGLQKIAGKLLKvskemsdnstyhaWSFISDEMFASADAHR 87   zebrafish
CAF94439        8 CCYNKLYQNVKRLSKAGEYFCKELMTVFQQRAELELTYAKGLQKLAGKLLRaskgmsqnstysaWCHMSDEMYSRADAHR 87   spotted green...
EEB18041        1 MTGQNGFEELRRYIKQGGDFCKELSVILQERSEAENQYAKSLSKLSHKLLKtskdav-gtvseaWQRLGAEMEVQSEIHR 79   human body louse
XP_971336     363 AEGQNGFEDLRRYVKQGGDFCKELATILQERAEAETQYAKNLSKLSSKLSRacrdgv-gglneaWKAVAIELETRAEIHR 441  red flour beetle
Feature 1                                                                                         
Q6WKZ7         88 KLGKAIELEAIKPTHQVLSMQEKk-RKSLDNEVEKTANLVINNWNQQIKAKKKLMMSTKKHEalfhlvesskqsltqk-- 164  house mouse
XP_002217370   87 NLSSALNEDAWKPLKSFIDAQSKt-RKPMKVTTYLHARENERLQEQLDDVNSGKGRVFSEKEisklnkk----------- 154  Florida lancelet
XP_001635935   88 TLANQLHGEAAKQIKAFVETQSKt-RKPVEVEVEKAYKNFSDRLSDSLKKKGASHSKSKEVEtlhdqmedt--------- 157  starlet sea a...
ACI03580      637 QLAASLTDELVKPLKIVVEGHHKa-RKAVESNVDKAARVLGEWRASEAKAKKASHTAARENEklqdamldvriqkspsia 715  fruit fly
XP_002120023   88 DFGLSLIEECIKPLSTVTEKQLKp-RRMMEQRVDSRFKTWTDKHAEHIKIKRRLHQLQRENEslreqi------------ 154  Ciona intesti...
NP_497805     126 NLGSAITEDIIQPLRSIQSNQQKt-IRAADNFVEREIRKLKDKKDETQKMKRSLYVLAKELEkten-------------- 190  nematode
XP_001599805  503 AWGSALGEQLAKPLRVGVAEVQGrtRKSIENSVDKASKSLQEWRTVAAKTKKQSFACARENErlqdlarlqsisqthqqh 582  jewel wasp
NP_001107076   88 ILGNALNQDVIQEIRQILDEHGKr-KRPLDNAVEKSGKLVLTNWSEQIKLKKKLIGLTREHEalfsfveknkqictek-- 164  zebrafish
CAF94439       88 SLGNAFQQEAILELRQLLDEHTKr-KRPFDSAIDRTGKLVTLNWSEQLKVKKKLSGLTREHEalfnfvegnkhictkk-- 164  spotted green...
EEB18041       80 NFAVALSEDVVKPLKQLIDSQHRi-RKNVEGVVDKTAKTLTEWRQAECKSKKQSFLCARENEklqdtildvrnnrn---- 154  human body louse
XP_971336     442 LMGQALSEETAKPLRNMTENQHRt-RKQCEGTVDKAAKSLAEWRTAEAKSKKQSHTCARDNEklqdaavldtlnrs---- 516  red flour beetle
Feature 1                                #   #                        #   #  #  ##  #   #  #   #  
Q6WKZ7        165 ----ekqkllnklkkstekLEKEDESYYQKNMAGYSTRLKWESTLENCYKSMLELEKERIQLLCNNLNQYSQHISLFGQT 240  house mouse
XP_002217370  155 ------------kkkaednQQKSETEYLDLVVKAERSRHDWEGSAYKCCALMQTLEEERIKFMHELLNKYNTFLSDMGPK 222  Florida lancelet
XP_001635935  158 -----------kqgkgkavSDKDITKLEAKIKKGMESAIKSDKDYREMYMKTERTRLEWEATMSKYCQTCEKLEEERVGH 226  starlet sea a...
ACI03580      716 --llhqgpnkqaaekelksAEKDCVKLDNKRKKAEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGN 793  fruit fly
XP_002120023  155 -------------dgprpkTDRDQQKLMAKQQRGEEQIQRTDLEYYNSLIQLEASRQDWESASFECCDAVEDMEDDKFRQ 221  Ciona intesti...
NP_497805     191 ---------------saerEKAQPEKFALRRKKYKDQMIRSEDDYVWQTVDLEKQRRMTENVLRKGVESMESVERQRLAH 255  nematode
XP_001599805  583 qqqhqlqsnnklassghhmTEKEASKLETRRRKAEDSARRADTEFYTVTVRAERARLEYECTVRKAAKQMELLEEERLSA 662  jewel wasp
NP_001107076  165 ----ekqkmfnrlsksaelQVRVDEEYFNTNMEGHHIRLKLENTVKTCYQIVQELEKQRIETLANTLNKYSLFMTVYSQT 240  zebrafish
CAF94439      165 ----ekqkmlnrltksaevQMQVDDEYFKINMEGHQTRLKLENTLKNCHQILQELEKQRIEVLYDILNRYHLHMTSFGQT 240  spotted green...
EEB18041      155 -----astlhlhhhnhknvSDKESAKLDLKRKKAEESVKKADIEYYSFCVRAERCRLDWESAVTRGSYCFQGLEEERLSC 229  human body louse
XP_971336     517 -----ssliqlahmhnkntPDKENTKLEGKKRKAEDAVKKADIEYYTLCVRAERARLEWESAVLRGVNTFQSLEEERLNH 591  red flour beetle
Feature 1          #  ##  # 
Q6WKZ7        241 LTTCHTQIHC 250  house mouse
XP_002217370  223 MVHSCNRLGE 232  Florida lancelet
XP_001635935  227 LKDMFSLYGN 236  starlet sea anemone
ACI03580      794 MHNFAQQYAR 803  fruit fly
XP_002120023  222 LNHVLGKYVD 231  Ciona intestinalis
NP_497805     256 CQTALGRYKR 265  nematode
XP_001599805  663 LKDLANVYLA 672  jewel wasp
NP_001107076  241 VIHSHKQIDQ 250  zebrafish
CAF94439      241 LKHEISWTFT 250  spotted green pufferfish
EEB18041      230 LKNLASCYLK 239  human body louse
XP_971336     592 LKTVLTSYLH 601  red flour beetle

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