Conserved Protein Domain Family
F-BAR_Fes_Fer

?
cd07657: F-BAR_Fes_Fer 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) and Fer (Fes related) tyrosine kinases
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Fes (feline sarcoma), also called Fps (Fujinami poultry sarcoma), and Fer (Fes related) are cytoplasmic (or nonreceptor) tyrosine kinases that play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Although Fes and Fer show redundancy in their biological functions, they show differences in their expression patterns. Fer is ubiquitously expressed while Fes is expressed predominantly in myeloid and endothelial cells. Fes and Fer contain an N-terminal F-BAR domain, an SH2 domain, and a C-terminal catalytic kinase domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. The F-BAR domain of Fes is critical in its role in microtubule nucleation and bundling.
Statistics
?
PSSM-Id: 153341
View PSSM: cd07657
Aligned: 9 rows
Threshold Bit Score: 251.919
Threshold Setting Gi: 115502390
Created: 17-Jun-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              #  #      #  ##  #  ##  ##  #   #  #   #                                 # 
P07332          7 LCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQdsggqsrais------pdspisqswaEITSQT 80   human
AAA61190        5 SDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQvdkestvqmn------yvsnvskswlLMIQQT 78   human
XP_002126775    7 LLGKPSHEALIRLQDYEIKLLEVIKKTILGRIEHDRKYSNMLSQLANHglkiensmf--------qspifnawkEIVHSM 78   Ciona intesti...
XP_971555       7 LQGKSAHEALLSRQEAELRLLDAMKRCLLSKVRCDREYAVALGSVAAQglkldrgdel------qgslvaaswrTMMEEL 80   red flour beetle
XP_623692       7 LQGQSSHEALLARQDAEIKLLETMRRCLTIKVKSDREYASTICSLTMQgkkiernedl------vgsliaqswkDIMDSI 80   honey bee
NP_524288       7 LQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQglkidradem------qgsliskswrSYMDEL 80   fruit fly
CAA76605       13 LITRAGSEALLRLNDEEIRLLESMKTYMTKRAKADQDYAKELLRLRVDrstggalhrsdstsaeetspilkawhQFQAET 92   Sycon raphanus
EEB13817        7 IQTQTVHETLLGRQDFELRLLETVKKSLQSKIRCDKEYSSTLLGVVAQgqkiegsddl------lgsvitqswkTLLEGF 80   human body louse
BAA81721        4 FCLQSGRDCINKRHDDELKALESFRVYMHKRAKADAEYAVTLGKINSQtaremagvgan----siivqawngalEAMDSI 79   Ephydatia flu...
Feature 1          #                                                                              
P07332         81 EGLSRLLRQHAEDLNSgplsKLSLLIRERQQLRKTYSEQwqqlqqelTKTHSQDIEKLKSQYRALARDSAQAKRKYQEAS 160  human
AAA61190       79 EQLSRIMKTHAEDLNSgplhRLTMMIKDKQQVKKSYIGVhqqieaemIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEAL 158  human
XP_002126775   79 LQTSHCIKKSADFMQSstldKVTALIKDKTTIRKNYTENreridhkfVKTIHTELDKKHSSYMKLETEVAQAHKAYDAAV 158  Ciona intesti...
XP_971555      81 DSAGKLIRQNADCVESklmeALNAVYVEKRKMKKAYQEEhari-lqqFTHLSDEVNRKKSEYQKYLELYKLMRSRFEEHY 159  red flour beetle
XP_623692      81 DQTAKLIKQQADSIEAivveHITTLHSERRRARKIYQEEqtwl-nnqFQQLTDDVARKKLEYQKNLEMYKLMRSRFEEHY 159  honey bee
NP_524288      81 DHQAKQFKFNAEQLEVvc-dKLTHLSQDKRKARKAYQEEhaki-aarLNHLTDEVVRKKSEYQKHLEGYKALRTRFEENY 158  fruit fly
CAA76605       93 DRVSSLIAQHAQALNAitvqSVDKLLLNKKTAKKRFTTCrqda-daaYGRTTERVNKLKKSYQQLSADVSRKKTEFQKSV 171  Sycon raphanus
EEB13817       81 EFLAKLVKQNAEAIEInvldKINQLYLDKKKIKKSYIDEygki-slqFSKISDDVGKKKLEYQKNLEIFKSMRSRLEEFY 159  human body louse
BAA81721       80 QKKLLNCSQQVETLLH----NIDLLIKDKRGAKRAYDIGrsql-ddeYRKSCNEVQNLRREYVQTLQATTAAKKKLEQTV 154  Ephydatia flu...
Feature 1                       #   #                        #       #  #  ##  #   #  #   #   #  #
P07332        161 KDK------DRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEIS 234  human
AAA61190      159 AKGk-----ETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQIT 233  human
XP_002126775  159 EKGkf---nPIEKAQDKYRKTTMKLHHAHNDYTLQVMEAQLHQHQYRNQVLPELLSGMQHMETECAETLKQALHEFLTYS 235  Ciona intesti...
XP_971555     160 VKSgrg-grKLDDVRDKYQKACRKLHLTHNEYVLLLCEAVEFEKDFRTVLLPGLLEHQQSLQEAFITAWKQILQDIVTAS 238  red flour beetle
XP_623692     160 VKSgrv-grKLDEVREKYQKACRKLHLTHNEYVLLLGAVTECEHDLRTCYLPSLLHRQQAIHQEFITSWKTILQDIVKYS 238  honey bee
NP_524288     159 IKApsrsgrKLDDVRDKYQKACRKLHLTHNEYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYG 238  fruit fly
CAA76605      172 GSP------NQQDKMKRYIRAADKLCKCHNDYLLALQEVQEHQEAYRTRILPLLLNNMQQVCQGHAQQWMDALNDSLDNI 245  Sycon raphanus
EEB13817      160 VKGgrg-skKIEEIREKYQKTCRKLHLAHNEYVLLLAEATEFEKDFRILLFPGLLEYHQCLQDNLNHEWKKVFEDVARNS 238  human body louse
BAA81721      155 SKQpvk-paEVDKLRGKFVSSAAKLHKCHNDYTLAILNANTHLEHYHKSTVPFCLNTLQERMELIVSQWRKGMEEYARTT 233  Ephydatia flu...
Feature 1         #  # 
P07332        235 SLVQD 239  human
AAA61190      234 SLVTE 238  human
XP_002126775  236 SPCRE 240  Ciona intestinalis
XP_971555     239 DCTSE 243  red flour beetle
XP_623692     239 DFTTD 243  honey bee
NP_524288     239 DLTAD 243  fruit fly
CAA76605      246 DSCRD 250  Sycon raphanus
EEB13817      239 SLCTE 243  human body louse
BAA81721      234 DMTQV 238  Ephydatia fluviatilis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap