3HAJ,3HAI


Conserved Protein Domain Family
F-BAR_PACSIN

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cd07655: F-BAR_PACSIN 
Click on image for an interactive view with Cn3D
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins, also called Synaptic dynamin-associated proteins (Syndapins), act as regulators of cytoskeletal and membrane dynamics. They bind both dynamin and Wiskott-Aldrich syndrome protein (WASP), and may provide direct links between the actin cytoskeletal machinery through WASP and dynamin-dependent endocytosis. Vetebrates harbor three isoforms with distinct expression patterns and specific functions. PACSINs contain an N-terminal F-BAR domain and a C-terminal SH3 domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153339
View PSSM: cd07655
Aligned: 19 rows
Threshold Bit Score: 315.408
Threshold Setting Gi: 221120129
Created: 16-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceputative
Conserved site includes 54 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:3HAJ_AB; interface between monomers in human Pacsin2 F-BAR dimer; defined at 4A contacts.
    View structure with Cn3D
  • Structure:3HAI_AB; interface between monomers in human Pacsin1 F-BAR dimer; defined at 4A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ###     ##  #  #  ##  ## ##  ##  ## ##  ##  #  ##                #  #  #       #
3HAJ_A        18 FWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKgpqygtvekAWMAFMSEAERVSELH 97  human
NP_001091172  18 FWMPNNYSSTVKRTEDGHRLCDEIVACFQDRAKIERQYALQMEEWTHKWKPLVDSspmygsllrAWQAFMSATERLSELH 97  African clawed ...
XP_002128138  19 FWEVNQYKRTVTRIDNGMKLCDDLMLFIKERATLEEQYSKLLKQWSSKFHKLVEKnssyhtlqtTWLGMLNEADRTAQLH 98  Ciona intestinalis
XP_002115575  28 FWDIGNYKRTVKRVDDGVKLCDDMLAMIRDRMELERAYARSLKRWASDWRSSIQNgpeygtmeeSWKACFTEADEVANLH 107 Trichoplax adha...
CAZ31070      18 FWECREYHRTVKRVDAAYKLCNELCLMIQERAELEKAYSSNLKKWSSRWLSFLDSgleygsgssPWKGLCKEAEAVSNAH 97  Schistosoma man...
XP_001634752  21 FWDVGNYKRTVKRVDDGSKLCDEFMKMVTERAEIEARYSAKLKVWAKKWEEVIKAgseygsmeeAFKGAVDEANSRASVH 100 starlet sea ane...
XP_002165712  25 FWDIDNYQRCVKRIGESSALCDDLVKMFNERIEIEAKYGKKLDDWHEKWSKALENscmyattkvAALGTIKEAQDRAKVH 104 green hydra
NP_001024665  16 FWEVGSYKHNVKRFKDGVEQLDDYCKMSRERAEIEAKYSKMLSQHAEKWRAHVDRtvsagsvktVWNELIGEATALSRVH 95  nematode
XP_001634003   2 FWQVNNYKRTVRRVDDGAKLCDDFMKMVSERAEIEALYAAKLQAWSRKWLDLLNKgpeygsckdSWVHVTSEAEQVAQVH 81  starlet sea ane...
XP_002162969  88 FWVENNYKKVVKRIEDGVHTIDDLSKMVEERSAIESFYGNKLKGWSLKWFDTFNRycesniinqALKKSFDEVDSLATLQ 167 green hydra
Feature 1                                                         #   #                          
3HAJ_A        98 LEVKASLMNDDFEKIKNWQKEAFHkqm--mgGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREan 175 human
NP_001091172  98 TQIQKTLVAEDSEKIRTWQKETYHrki--fgGFKESCEIENGFHKAQKPWAKKLKKVENSKAAYHKACKKEHLAIVREns 175 African clawed ...
XP_002128138  99 STIKEQLMADPYEKVKQWKKENYHtlt--lgGIKESKLLNEEFMRAQKQWAKYMKKVTDAKKTYFNVCKEERSAQTQEst 176 Ciona intestinalis
XP_002115575 108 ADVREKLLSKAYDSVKKWKKDHYHks---mmHYKETRDCDDNFSRIQKPWAKRFEKVVKAKKEYYSAAKAEDNNNKQLnt 184 Trichoplax adha...
CAZ31070      98 QNVRNILIDEIQTEVKQWQKEHFHksslppqTLKETKQFEQDFEIAQKQWSKRLKKVHTTKKEYYQACKTERSLQVQVrn 177 Schistosoma man...
XP_001634752 101 TQCRDDLLNDVVELVKKWKGDNYQks---mfQWKQVKEAEEGFARAQKPWAKLLMKVMRSRKAYHNAAKATEQAKKLQie 177 starlet sea ane...
XP_002165712 105 MDCCMKMQNQVIETIKRWKESNYHhk---ifGLKEAKEYEQEFAKAQKQWANAYNKIQKAKGNYHSACKNREACASLLnn 181 green hydra
NP_001024665  96 NSLKDCLIDDIVNETTTYRKNSLHtsv--fkGPKEIREIEDHFEKAQKPWKKLVDKMEDKRGKYYNVCRQEKSALVNLqn 173 nematode
XP_001634003  82 INLQSTLLSRVHESVAAWKGANYHks---llSWKETKNAEEGFSKAQRPWAKRYDDVLKSKKAYYAACRARDQAEKLYns 158 starlet sea ane...
XP_002162969 168 LSISSKLEALSNNIVEWKNTTYCKqf----tKLKEVKRSEEAFAKAQKPWVIKSNEVLKCMIAYHNAGDSLDAVLKINni 243 green hydra
Feature 1                                            #              #  #   #  ## ##   #  ## ##  #
3HAJ_A       176 skadpslnPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHL 255 human
NP_001091172 176 skinpelsQEKLKKLTEDHEKCTQDKEKVKQRYEKSLQELNKYNPKYMEEMETVFDQSQQQEQKKILFLKQVLGSMHKHL 255 African clawed ...
XP_002128138 177 aksdtslaPEKVKKLQELVEKKGAEKSKYREKYEQAVRALKDDTPRYMEDMEKVFVKCQEFEEKRLEKFKAIFHAVHGHL 256 Ciona intestinalis
XP_002115575 185 aesdnnmaADQVKKIRDKADKASKEASRAKDRYKERLEDLTTFNDSYQKSMTEEFDRWQAFEEDRLIFFKEMLVVIHNCV 264 Trichoplax adha...
CAZ31070     178 aksdpsgtAEQLKKTQEKLAKAEKDVHRTRDAYKIALADLNTESSRYVEEMTKVFNRTQDFERERLSFFKEIFNSLHSAL 257 Schistosoma man...
XP_001634752 178 assdpnvpQEKFKKLTDAVEKARRDMQKCEDKYNDRLENISKDNPRYERDMTEQFERCQAFEQKRKDFFKDALMKYHSCL 257 starlet sea ane...
XP_002165712 182 akqdtetlPEKIKKLEDSLRKSENSVSTMQQKYDEKLKRISPLNITYESDMQQVYNKWAKDEEKRLDFLQRTLIDFHKCV 261 green hydra
NP_001024665 174 cqtdtsvsPDAATKFRERHEKLKEEVQRTKVDYQKTLTNLNEYKNVYMEAMAHVFKMCQEKEMDRSQFLIGIVQKTQRHY 253 nematode
XP_001634003 159 sdp-ntmkEDQIKKTKEKLMKSEREVSTTQDKYKEAVRDITNYNPKYKEDMCFVFDKLQAFEGERKAFFKQTMQGLCNAL 237 starlet sea ane...
XP_002162969 244 ka--vsdvPDDQKRLKDKLRKLEEEVSITRGKYEEAIRDISNYNPKYQDDMRYEFNNCQTFEEARKNFVKESLLNYQACL 321 green hydra
Feature 1        ###    ##  #  ##  ##
3HAJ_A       256 DLSNVAGYKAIYHDLEQSIR 275 human
NP_001091172 256 DITTNESAKTVYGDLNDAIV 275 African clawed frog
XP_002128138 257 DLSTNVEHKAIFVDLKSNID 276 Ciona intestinalis
XP_002115575 265 NIADNPNFSKIYNEMLQTIE 284 Trichoplax adhaerens
CAZ31070     258 NVCAKVDYDSIYNELAESIS 277 Schistosoma mansoni
XP_001634752 258 DVSRKSEFSGIFLHMSTTFQ 277 starlet sea anemone
XP_002165712 262 NIYADPRLYVKLFKMILLCF 281 green hydra
NP_001024665 254 ANIIRNSQMSGLHQQLEQSI 273 nematode
XP_001634003 238 NVQQFTQIYNELSNKFEKTE 257 starlet sea anemone
XP_002162969 322 NRTSAFEIIYNQLKRDYETI 341 green hydra

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