Conserved Protein Domain Family
F-BAR_FCHSD

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cd07654: F-BAR_FCHSD 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of FCH and double SH3 domains proteins (FCHSD)
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. This subfamily is composed of FCH and double SH3 domain (FCHSD) proteins, so named as they contain an N-terminal F-BAR domain and two SH3 domains at the C-terminus. Vertebrates harbor two subfamily members, FCHSD1 and FCHSD2, which have been characterized only in silico. Their biological function is still unknown. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153338
View PSSM: cd07654
Aligned: 4 rows
Threshold Bit Score: 393.873
Threshold Setting Gi: 74714119
Created: 17-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #  #      #  ##  #  ##  ##  #   #  #   #                                #  
NP_055639      16 NIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDwpgvkaddrndyrsMYPVWKSFLEGTM 95   human
XP_002220851   16 TVHSEHISKLQAKHETECNLLEDIRTFGSKLSALEKDYGQALEKLVKQFQKREypaddelkppnhrsVYVVWAALIEQAD 95   Florida lancelet
Q86WN1         16 LRFLEQLSILQTWQQREADLLEDIRSYSKQRAAIEREYGQALQKLAGPFLKREghrsg----emdsrGRTVFGAWRCLLD 91   human
XP_683650      16 HTHTEQLNRLQLKHQTDLDFLEDLRTYSQKKALIEKDYSQALHKLASQYLKREwtgapseeprdsrnIWAVWRSYLEGVM 95   zebrafish
Feature 1         #                                                                               
NP_055639      96 QVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKAdi---- 171  human
XP_002220851   96 TLAKARLATAEALRTGIVEPAKTLKSSKDLQLKKCTEQLNLLHQEVTLTVKEMNKLKKTYFEVEHVAHDAREKAkdaesk 175  Florida lancelet
Q86WN1         92 ATVAGGQTRLQASDRYRDLAGGTGRSAKEQVLRKGTENLQRAQAEVLQSVRELSRSRKLYGQRERVWALAQEKAadvqar 171  human
XP_683650      96 KVSQSRINRCENYRSQISDPVKTFRTQKDLQLKRCSEQLSRAQADLQGTIRDLEKSRKTYQEAEQTAQSVREKAem---- 171  zebrafish
Feature 1                               #   #                        #    #  #  ##  #   #  #   #  
NP_055639     172 eAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIA 251  human
XP_002220851  176 mKRNATSIFQSKATLQKNSAKLSARKDTCDSKSAAARNDYLMSLAAANAHQKRYFQTDLPEIIEDCDGDIYDNMKEFLVL 255  Florida lancelet
Q86WN1        172 lNRSDHGIFHSRTSLQKLSTKLSAQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTS 251  human
XP_683650     172 eAKSRLSLFQSRSSLKRASVKLKAKKNEWKSKATQSRNDYLLALSATNAHQDRYYETDLISCIRVLDGGFYDHAQGFLIW 251  zebrafish
Feature 1          #  ##  #               
NP_055639     252 FSRTELETCQAVQNTFQFLLENSS 275  human
XP_002220851  256 LNKTQVELNTQAARSFRDVLSQAE 279  Florida lancelet
Q86WN1        252 LSHTELEAAEVILEHAHRGEQTTS 275  human
XP_683650     252 LCQTELETSQSIQDTFQSLLETSS 275  zebrafish

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