Conserved Protein Domain Family
F-BAR_Rgd1

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cd07652: F-BAR_Rgd1 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Saccharomyces cerevisiae Rho GTPase activating protein Rgd1 and similar proteins.
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Saccharomyces cerevisiae Rgd1 is a GTPase activating protein (GAP) with activity towards Rho3p and Rho4p, which are involved in bud growth and cytokinesis, respectively. At low pH, S. cerevisiae Rgd1 is required for cell survival and the activation of the protein kinase C pathway, which is important in cell integrity and the maintenance of cell shape. It contains an N-terminal F-BAR domain and a C-terminal Rho GAP domain. The F-BAR domain of S. cerevisiae Rgd1 binds to phosphoinositides and plays an important role in the localization of the protein to the bud tip/neck during the cell cycle. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153336
View PSSM: cd07652
Aligned: 14 rows
Threshold Bit Score: 290.403
Threshold Setting Gi: 213403192
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #      #  ##  #  ##  ##  #   #  #   #                             #  #  
EED46620      50 VYSDIGITTLLTRLKQSVASARDFSTFLKKRSSLEEEHAQGLRKLSRSlldasvr--tdnrqgTYGQSHNDLSRFHDRMA 127 Aspergillus fla...
XP_760729    358 CDIDCAMPLLFDRIKQSMVSAREAATFLKKRAVLEEEYARGMAKLARTtfetysl--sdakagTFVKSWHSIVKTHETLA 435 Ustilago maydis...
EEB90971       5 LVALFSVSSFDEGILRALCDMDEASVFFKIRAAIEEEYGKSLQKLARTtsevysm--ndgkagTFVYAWQASMRIHDTMG 82  Moniliophthora ...
NP_595866     39 LNSELGLAILNDRIKDYLLTCKELAGFFKKRSILEEESGKNLQKLAKSyletfqs--khhspqSFSASVITSMEIHEQLA 116 fission yeast
XP_002172368  22 VYSNLGLVTLNDCVKSSIANAKEIIIFLKKQSSIYEDYSRNLGRLSKStkdtfk---htqlqtSFHNVMSSMITFHEDIS 98  Schizosaccharom...
AAB82943     105 LHSDVGIATLLNRLKASISSARDFASFLKRRGALEEEHAGSLKKLSRGtldgvrk--pdsrheSYQTQFEQVLHANERIA 182 Cochliobolus he...
XP_499681    134 MLSDVGISSLLARSKQSIVSCKEFAQFIKKRGALELDHITHLKKLSRNtrdaikr--pehrqgTFYRQFDEIARVGERVS 211 Yarrowia lipoly...
CAY71941      57 LQSDSAMDILLDRLKRSITTCDEFSRYIKKKSILEDDHYTQLRKISKHtqdtlkndgkkfktdSFERSFEKIVSFDSELF 136 Pichia pastoris...
CAG86109      20 LNSDGSLDVLLNRLKQSITTGEEFSKFVKKKALIEDEHYNQLKKFASHtrttmks-saklkndSFSNKLDSIIEFDEKLF 98  Debaryomyces ha...
NP_009819     39 LNSDVAINALLSRLKQSLLTCEEFMKFIRKKYAFEEEHVQELSKQYKHffniq-----gstnsSLKKMIHEVLGFDGKMA 113 baker's yeast
Feature 1                                                                                        
EED46620     128 DHGLQFAVSLQQMADSLHELAANIERGRKQWKQTGLSAEKRVMEAEAAAEKAKAKYESLAEQY----DRVKTGDKQSg-- 201 Aspergillus fla...
XP_760729    436 DNRLRFATKLNEMSEELSNLSKEVDKSRKHARETGLRLEKNLQDAEVGVEKARGRFDTAAEDL----ERLLLLKSGEstk 511 Ustilago maydis...
EEB90971      83 DNHIRFAQRLNEMSDELANIAKEVDKNRKSTKELATRYERALQEAEGVTEKSRNRLDTTSEEL----ERVLLQKEGEsl- 157 Moniliophthora ...
NP_595866    117 NHSLTLQKTLSAFSDQVIEFHKNAERKRKSIKEYAKKQENAYLEAVMQMDKSKSRFKGAETEYnralDNKNTGDSQKkv- 195 fission yeast
XP_002172368  99 QNASLYARASEKSSNEFADFLKASEKKRKSIKEYAKKQEFVYTDAMSQLEKATARFKVAEQDYnr-aTEIKTGEKKPls- 176 Schizosaccharom...
AAB82943     183 DNGTQFGLALHAMHENLLQLANKMDGNRKTWKQQGLSAENKVQEAERLAEKAKAKYDQLAEDL----DRVKTGDTGAgr- 257 Cochliobolus he...
XP_499681    212 DVSATFVTKLNAMNDELSELARTTEKTRKQVKETHLRHEKNLVDLEQAAEKAKSKYESLYDDL----ERARTGDPTKn-- 285 Yarrowia lipoly...
CAY71941     137 NVGSPYVKALTLMYEQLGSLASTVSKSRKSVKEEYRRKERECGDAIAAAEKSKNKYFNFCNEL----EKLRTGDPSKk-- 210 Pichia pastoris...
CAG86109      99 NVGSSYVKALNVMYDELTSLVGTVSRSRKTIKEESKRKEKECSDAIMTAEKAKQKYFHLCDDL----EKLKASDPNKk-- 172 Debaryomyces ha...
NP_009819    114 QVKQSYITALQKMYSEISSLLLTMTKLRKSVKENSKRLEKDVSDAIHSAEKAQSRYNSLCQDW----DKLRMTDPTKt-- 187 baker's yeast
Feature 1               #   #                        #    #  #  ##  #   #  #   #   #  ##  #      
EED46620     202 -kFGLKGPKSAAQHEEELLRKVQNADSDYASKVQAAQAARqELVSTHRPQAVHNIQQLISECDSGLTLQMQKFATFNEKL 280 Aspergillus fla...
XP_760729    512 sgEMQSGAASVGSSGKRTLGKAIGKSGLLFKNKNPQQILKqEEEVRARTSSASDAFRREVLSTQGIRQEYFHLQLPRILR 591 Ustilago maydis...
EEB90971     158 -kDNSVQARSGGAGGKRAIGKAVAKGGLLLKGKNPGNIQRqEDDIRARVSAASDAFRKAVIDTQSMRQEYFNFQLPRILR 236 Moniliophthora ...
NP_595866    196 gfFKPKSNAQLTKLEDEARLKAENAESDMHSKIENAQNVQkQLLCIHRPNYIKQFFSLQREIESSLIANYLRYTKLCESN 275 fission yeast
XP_002172368 177 fvFNKKSNAQLLKHEDDTRVKVEMAETDLASKTENAKSVQrELLLIHRPNYVKRFLSLLREIDAALRAHMIRYTRLSESY 256 Schizosaccharom...
AAB82943     258 -kFGLKGPKSAAQHEEDLQRKTQAADQDYASKVQAAQALRkELIATTRPQAVSALLDLIKETDAALTMEMQKFASFNEKL 336 Cochliobolus he...
XP_499681    286 -kFGFKTTKNSVQHEEELQRKVQAADQDYQQKVSAAQRSRqELLRVRRPEASRDLKDLIFECDSGMSLQFQKFANVCETL 364 Yarrowia lipoly...
CAY71941     211 -tFTLKGSKTGTQQEEELSRKIEIADQDYRAKVHQCKKLKdELLMVHRPAQVKALKGLILEIDTAMSLQLQKYTTWNETL 289 Pichia pastoris...
CAG86109     173 --SFSLKNKSAEQQEDDLQRKVDASDQDYKSRVTTCKKLKdEILMMHRPASSKKLKNLILEMDIAMNVQLQKYATWNENL 250 Debaryomyces ha...
NP_009819    188 -kLTLRGSKTTKEQEEELLRKIDNADLEYKQKVDHSNSLRnTFITKERPRIVQELKDLILEIDTAMTIQLQKYTIWTENL 266 baker's yeast
Feature 1          
EED46620     281 LL 282 Aspergillus flavus NRRL3357
XP_760729    592 TL 593 Ustilago maydis 521
EEB90971     237 SL 238 Moniliophthora perniciosa FA553
NP_595866    276 TL 277 fission yeast
XP_002172368 257 VL 258 Schizosaccharomyces japonicus yFS275
AAB82943     337 VV 338 Cochliobolus heterostrophus
XP_499681    365 AL 366 Yarrowia lipolytica CLIB122
CAY71941     290 VM 291 Pichia pastoris GS115
CAG86109     251 IM 252 Debaryomyces hansenii
NP_009819    267 VL 268 baker's yeast

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