3G9G


Conserved Protein Domain Family
F-BAR_Syp1p_like

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cd07650: F-BAR_Syp1p_like 
Click on image for an interactive view with Cn3D
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of yeast Syp1 protein
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Syp1p is associated with septins, a family of GTP-binding proteins that serve as elements of septin filaments, which are required for cell morphogenesis and division. Syp1p regulates cell-cycle dependent septin cytoskeletal dynamics in yeast. It contains an N-terminal F-BAR domain and a C-terminal domain of unknown function named SAFF which is also present in FCH domain Only (FCHO) proteins and endophilin interacting protein 1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153334
View PSSM: cd07650
Aligned: 18 rows
Threshold Bit Score: 229.132
Threshold Setting Gi: 58260748
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceputative
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #  #      #  ##  #  ##  ##  #   #  #   #                        
3G9G_A        39 KSPYEATETIRIRLSQVKLLNKDFYLLFKELANLKRNYAQQLRKIIAENEDITKILNAQMi-------eSNVLTPQEMSA 111  baker's yeast
XP_385122     16 LQPGQAVQTLTERMKRMTRVNTEVADWLQERRRVEDQYVQGLKKLTQFKVPNGQSELGVFq--------APWNRIIDSTE 87   Gibberella zea...
NP_009959     16 KSPYEATETIRIRLSQVKLLNKDFYLLFKELANLKRNYAQQLRKIIAENEDITKILNAQMi-------eSNVLTPQEMSA 88   baker's yeast
XP_758505     22 GKPRDSASLIQQRLRKAKLFNEELADYFAARRELEDTYLKQLQKISKRNFLSDPSSIPPSy-------aPVYERLVQELA 94   Ustilago maydi...
XP_449472     16 KDPYEATETLRIRLSQAKLLNTNLYLFLNQLADLRRNYNQQLRKIIIENEDLNSMLRKQMi-------eNNVLTAEEMQH 88   Candida glabra...
CAQ43501      16 KGPYEASETVRIRLSQAKLINKNFYLFFKEIANLKKSYTQQLRKIIDDNEDLNKILKSQMl-------eTKVLTEQEMGN 88   Zygosaccharomy...
XP_001646845  16 KEPFESTEAIRIRLSQAKLINKNFYLLLKDIADLKQNYVQQLRKIVAQNDNLDQLLKKQMi-------eNQVLTREELAN 88   Vanderwaltozym...
CAR23949      16 KGPLEATEIIRLRLSQAKLINKNFYLLFRELSEMKRNYAQQLRKVIAENEHLEKMLARDMl-------eNRVLTAEELRN 88   Lachancea ther...
XP_002174312  17 FAPKDSMTVFRRRLERIRSDNDRLAHWLRERTEIERDYAVRLQKLANSMNEGNVQELSLS---------DAWLELERDMQ 87   Schizosaccharo...
XP_567784     17 TPPRPLLAALQKRLHASTAHLAALADIYKQRAAIEAAYADGLHKLARTAEQGGLTGKAGNdwprgsaeaRLWDSVVSELA 96   Cryptococcus n...
Feature 1                #  #                                                                    
3G9G_A       112 FRFNSLGELRNVWDTVIEELKSDLKSSTEYYNTLDQq---VVRELKESVENNTSWRESKDLHSKLSKNAASiehysk--n 186  baker's yeast
XP_385122     88 SIAHAHHQLADRIEKDIEHPLRNFSNRKDFQNMNTMsn-nLSTMAKDLDDSQNAVDKLTKKGGRANTSKVEsa------- 159  Gibberella zea...
NP_009959     89 FRFNSLGELRNVWDTVIEELKSDLKSSTEYYNTLDQq---VVRELKESVENNTSWRESKDLHSKLSKNAASiehysk--n 163  baker's yeast
XP_758505     95 EVASAHAEFEKRIAQDCEAPIRNASSQGEWSRIKDHdd-sLSNTLRELNSLESQLQKDTKKLEAASSKKASqanak---v 170  Ustilago maydi...
XP_449472     89 FTFNSLGEIEPLWNTLVSELKLDLAANTKFSKVIEDe---VILGIKNSVEKNSNWGTSKHLHSKLSKVAVSlkrn----- 160  Candida glabra...
CAQ43501      89 FNFESLGDLESIWLAIVDELKADLRASSEFCNTLEEe---VIGGLERANENDHRWSQSKKMHSNLSQVAANidylvr--t 163  Zygosaccharomy...
XP_001646845  89 FSFNSVGELNQLWDTLLGELKSDMNATTQFQLMLQHd---IVSNLKNATESDGRWSESRKLHSRLTQVASKidyykq--h 163  Vanderwaltozym...
CAR23949      89 FQFDSLGPLKQMWAGVFDALKLELQTSTDLYHTLDRd---VIANLKDFTEKDPRWNQSRHLHSSLSKIAVDiersgresg 165  Lachancea ther...
XP_002174312  88 LRSKLHNSMAKQLGGQVYKPISEFYTSSPQMASLRElesrLSSVARSMDPSSISKVLRSNKHKRGQSQDGQlm------- 160  Schizosaccharo...
XP_567784     97 ETSASHSTLSAMLRTDFEQPIREIPNKVVAWRRIGDq---DANLDKTLRDYEKVSAKLEKASSKSKSSKVDal------- 166  Cryptococcus n...
Feature 1              #   #                         #   #  #  ##  #   #  #   #   #  ##  #       
3G9G_A       187 nensSHLEEARRQWDQQSPYLFELFETIDYNRLDTLKNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKD 266  baker's yeast
XP_385122    160 ---tSKLESATGQWESQAPFIFESLQALDESRVNNLRDLLTQYQTHESDSAQRVQENAMETLALMLEINTEKEIESFVHR 236  Gibberella zea...
NP_009959    164 nensSHLEEARRQWDQQSPYLFELFETIDYNRLDTLKNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKD 243  baker's yeast
XP_758505    171 qeteRAIAQTMEIWETEAPFAFEAYQRIDAHRLELLKESVAKFETAQSDAAQRIMSSSEKTMQQCLTFDTQADMQDFILK 250  Ustilago maydi...
XP_449472    161 -kdpNTHAELQSEWDADKAKLFQIFETMDYERLYSVKDCLLKYQSGYTDYILKTTEKCDTYMTQFLEFNPEKEIQRFAND 239  Candida glabra...
CAQ43501     164 ndrdGKLDELSKRWDTQGPMLFELFETIDHDRLATLKKCALRYQTGYGDYILSTSKQSEESMEKFLEFDPDVEIDRFARE 243  Zygosaccharomy...
XP_001646845 164 gergSKVDEVNTQWSTEAPYLFELFENIDHDRLATIRDSLLKFQTGYSDYLLSSTRQCESDMNTILSFRPESEIERFARD 243  Vanderwaltozym...
CAR23949     166 asekKNLQEASSQWDSQAADLFELFESTDYHRLLCLKNCLLTYQSGLGDYLAQNTQKSEEVMAQILGFDPEREIDRFARD 245  Lachancea ther...
XP_002174312 161 --ldNNELISRTAWDSEAPFAFEKLQTVDEERLIMLKQVYLTVSSLENQVGRQLNESSETCMAIFSTISAEEETIRFASE 238  Schizosaccharo...
XP_567784    167 ---qSDINNITHALSSLSPMVYTTYQRLDEERLRALKEIIVRWATVKGDMASRDGQRAEAIVSHLLQWETSDEVMDVGRK 243  Cryptococcus n...
Feature 1               
3G9G_A       267 ASQYNFQ 273  baker's yeast
XP_385122    237 ATAGKAK 243  Gibberella zeae PH-1
NP_009959    244 ASQYNFQ 250  baker's yeast
XP_758505    251 NGVVVGA 257  Ustilago maydis 521
XP_449472    240 ASNYKFS 246  Candida glabrata CBS 138
CAQ43501     244 ASRYSFQ 250  Zygosaccharomyces rouxii
XP_001646845 244 AANYNFQ 250  Vanderwaltozyma polyspora DSM 70294
CAR23949     246 ASSYNFR 252  Lachancea thermotolerans
XP_002174312 239 TVKNGAV 245  Schizosaccharomyces japonicus yFS275
XP_567784    244 LGAIGGA 250  Cryptococcus neoformans var. neoformans JEC21

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