Conserved Protein Domain Family
F-BAR_PSTPIP

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cd07647: F-BAR_PSTPIP 
The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Proteins
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. Vetebrates contain two Proline-Serine-Threonine Phosphatase-Interacting Proteins (PSTPIPs), PSTPIP1 and PSTPIP2. PSTPIPs are mainly expressed in hematopoietic cells and are involved in the regulation of cell adhesion and motility. Mutations in PSTPIPs have been shown to cause autoinflammatory disorders. PSTPIP1 contains an N-terminal F-BAR domain, PEST motifs, and a C-terminal SH3 domain, while PSTPIP2 contains only the N-terminal F-BAR domain. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules.
Statistics
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PSSM-Id: 153331
View PSSM: cd07647
Aligned: 6 rows
Threshold Bit Score: 346.386
Threshold Setting Gi: 221106857
Created: 19-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structures of the F-BAR domain dimers of human FCHO2, human Pacsin1 and human Pacsin2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #      #  ##  #  ##  ##  #   #  #   #                       #  #        
P97814        16 FTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKaggqtemn-slrtsfdSLKQQTENVGSAHIQL 94  house mouse
XP_001626908  13 FTSTAGFDALSKRMRDGKQTCQEMEEFVKQRADIEEKYGKSLMRLAKTseakdeig-tlksswdSLRNETENIGKAHVAL 91  starlet sea ane...
XP_002168994  14 FNGTLGYDMLLLRLKEGKKFCDSFTDFLRNRSKLEDDYGKNLIKLSQSganidesg-slkaswdSIRKGTEYVGNIHCEL 92  green hydra
Q9H939        15 ILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKkpcgqseintlkraleVFKQQVDNVAQCHIQL 94  human
XP_002230746   2 FCSTQGFETLLARMKEGSNMCKELEDFLKHRAKAEEDYAKTLQKMVKSagdggeig-ilrnawdTVRKETEHLANVHMTM 80  Florida lancelet
XP_002128806  17 FVTQTGFETVVTHVKEGQRACKWLEDYLKLRSKAEDEFAKALLKASKLelptmeysgtlkssldTYRTEAEEEANFHSNL 96  Ciona intestinalis
Feature 1                                                                                        
P97814        95 ALALREELRSLEEFRERQKEQ-RKKYEAIMDRVQKSKLSLYKKTMESKKAYDQKCRDADdaeqafervsanghq------ 167 house mouse
XP_001626908  92 AQQLLDSLEKGLQEFRENQKEtRKKLEDSVKRSQRNKKTCYENLHKLKRTYEQKCREKEaaddalkksvsmaakdeektl 171 starlet sea ane...
XP_002168994  93 AKKLNDLLDRTSKFREKYKNE-QLKVDDKMKKSQKEKKVAYENLNKAKKVYEQRCRETDqcqelydskssftqk------ 165 green hydra
Q9H939        95 AQSLREEARKMEEFREKQKLQ-RKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDeaeqavsrsanlvnp------ 167 human
XP_002230746  81 SQSLTKEAEDIRGFRKLQEQS-RKETEEDNMKYTRLKRDLYKKTMDAKKSYDQKCREADgaenaystsrvtaqq------ 153 Florida lancelet
XP_002128806  97 AQRFSEEASKLNEFHGKQKEE-RKKHEDIVHRTHKNKAELYRKMMQCKSSYESKCKSSEkadsdaeklkfgnkp------ 169 Ciona intestinalis
Feature 1                                   #   #                        #   #  #  ##  #   #  #  
P97814       168 -------kqveksqnkakqckeSATEAERVYRQNIEQLERARTEWEQEHRTTCEAFQLQEFDRLTILRNALWVHCNQLSM 240 house mouse
XP_001626908 172 hssivyghttekapvlvrspklSSVEHDSAYQTSVRVLDDTRVVWEREMATCCNVFQNLEEERIAFLRNWMWLYANLGSI 251 starlet sea ane...
XP_002168994 166 --------eeerlkrslsksktYAENSDSVYQSSVKILEDCHKKWASDMEEACQVFQNLEEERIQFLRNEFWIYTNLGST 237 green hydra
Q9H939       168 -------kqqeklfvklatsktAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQ 240 human
XP_002230746 154 -------keidklkkkasgarqQAEQADTAYKSCVEGLEQSRVSWEKCHAHSCQVFQKMEEERIMFLRDKLWVHSNLGSM 226 Florida lancelet
XP_002128806 170 -------keaekakknaaqcrsSALKADEDYKSSIGCVESARQLWITEHSTACDVFQRMEEDRIKCMRNTVWVCCNFVSD 242 Ciona intestinalis
Feature 1         #   #  ##  # 
P97814       241 QCVKDDELYEEVRL 254 house mouse
XP_001626908 252 NCVKVDEMYEVVRQ 265 starlet sea anemone
XP_002168994 238 QAVDIDEKYEDCRK 251 green hydra
Q9H939       241 QCVTSDEMYEQVRK 254 human
XP_002230746 227 ICVQNDEHYEDMRK 240 Florida lancelet
XP_002128806 243 VCCKLDNSRERIRQ 256 Ciona intestinalis

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