Conserved Protein Domain Family
BAR_ACAP1

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cd07639: BAR_ACAP1 
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. ACAP1 (ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 1), also called centaurin beta-1, is an Arf6-specific GTPase activating protein (GAP) which mediates Arf6 signaling. Arf6 is involved in the regulation of endocytosis, phagocytosis, cell adhesion and migration. ACAP1 also participates in the cargo sorting and recycling of the transferrin receptor and integrin beta1. It may also play a role in innate immune responses. ACAP1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, and C-terminal ankyrin (ANK) repeats. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153323
View PSSM: cd07639
Aligned: 3 rows
Threshold Bit Score: 325.33
Threshold Setting Gi: 3183210
Created: 10-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##         ## ##  ## ##  #             #  ##          
Q15027        18 RASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFVVGICDLARLgppepmmaecLEKFTVSLNHKLDSHAEL 97  human
NP_001085843  18 RAAMEEVESEVSDLESRLEKLVKLSSHMNDGGRQYCSSSRHFVDALRDLSHHsrkdtilsecLEKFSDGLSKIIDSHVEL 97  African clawed ...
ACI33875      18 RADIEVVEGDVSELETRLEKLVKQCHSMLEAGRAYCQTSKSFVTGLKELGHHcsgdnmmgecLEKFSQKLEVILEAQGEV 97  Atlantic salmon
Feature 1                                                                                        
Q15027        98 LDATQHTLQQQIQTLVKeGLRGFREARRDFWRGAESLEAALTHNAEvprrraqeaeEAGAALRTARAGYRGRALDYALQI 177 human
NP_001085843  98 LENIQFSFKQRLLLLLKeDLRSFRDSRKELERCREGLESALQHNAEtprrktqevqDAATAVLGSRRTFRDRALEYALQI 177 African clawed ...
ACI33875      98 IETTQKSVKLKLQSFVKeDVRRFKDVRKEFERGSESLEAALGRNAQaprgkqheveEASHALLNARKTFRSGALDYVLQI 177 Atlantic salmon
Feature 1        #  ## #    #  ## ##  ##  ## ##  ## ##   
Q15027       178 NVIEDKRkfdiMEFVLRLVEAQATHFQQGHEELSRLSQYR 217 human
NP_001085843 178 NVIQGKKkfdiLQFMLQLMDAQASFLTQSHHAMQALHQYR 217 African clawed frog
ACI33875     178 NVIEAKKktdiLMAMVSMMEAQSQFFQQGHQSLSELANYR 217 Atlantic salmon

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