Conserved Protein Domain Family
BAR_ACAP2

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cd07638: BAR_ACAP2 
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. ACAP2 (ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 2), also called centaurin beta-2, is an Arf6-specific GTPase activating protein (GAP) which mediates Arf6 signaling. Arf6 is involved in the regulation of endocytosis, phagocytosis, cell adhesion and migration. ACAP2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, and C-terminal ankyrin (ANK) repeats. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153322
View PSSM: cd07638
Aligned: 4 rows
Threshold Bit Score: 380.886
Threshold Setting Gi: 220673138
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##         ## ##  ## ##  #             #  ##          
NP_001006548  18 RAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCLANKQFMNGIRDLAQYSckdalvetnLTKFSDTLQEMINYHNIL 97  chicken
BAA05064      21 RAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSsndavvetsLTKFSDSLQEMINFHTIL 100 human
CAX14104      18 RATIEDVEEDFGELESKLDKLVKLCIGMIDAGRVYNQANKQFVNGIRDLALQStrdevigssLAAFSETLQEMNNYHTIL 97  zebrafish
NP_001083420  18 RASLEDVEGDVSELEIKLDKLVKLCIGMIDAGKAFCAANKQFMNGIRDLAQYSskdsviensLTKCADSLQEMIKYHAML 97  African clawed ...
Feature 1                                                                                        
NP_001006548  98 FDQTQRSIKAQLQTFVKeDIKKFKDAKKQFEKVSEEKENALVKNAQVQRnkqheveEATNILTATRKCFRHIALDYVLQI 177 chicken
BAA05064     101 FDQTQRSIKAQLQNFVKeDLRKFKDAKKQFEKVSEEKENALVKNAQVQRnkqheveEATNILTATRKCFRHIALDYVLQI 180 human
CAX14104      98 FDQAQRSIRSQLQTFVKeDLRKFKDAKKQFDKVSEEKEVALVKNAQVPRnklheveEATNILTTTQKFFRNIALDYVLQI 177 zebrafish
NP_001083420  98 FDQAQRSIKTQLQTFVKeDLKKFKDAKKQFDKVSEEKENALVKNAQAQRtkqheveEATNILVATRKCFRHIALDYVLQI 177 African clawed ...
Feature 1        #  ## #    #  ## ##  ##  ## ##  ## ##   
NP_001006548 178 NVLQSKRRseiLKSMLSFMYAHLTFFHQGYDLFSELGPYM 217 chicken
BAA05064     181 NVLQSKRRseiLKSMLSFMYAHLAFFHQGYDLFSELGPYM 220 human
CAX14104     178 NVLQSKRRleiLKSMLAYMNANLTFFNQGHDLFSQLQPLM 217 zebrafish
NP_001083420 178 NVLQSKRRseiLKSMLSFMCAHLTFFHQGYDLFSELEPYM 217 African clawed frog

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