Conserved Protein Domain Family
BAR_ACAP3

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cd07637: BAR_ACAP3 
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3), also called centaurin beta-5, is presumed to be an Arf GTPase activating protein (GAP) based on its similarity to the Arf6-specific GAPs ACAP1 and ACAP2. The specific function of ACAP3 is still unknown. ACAP3 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, and C-terminal ankyrin (ANK) repeats. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153321
View PSSM: cd07637
Aligned: 4 rows
Threshold Bit Score: 421.332
Threshold Setting Gi: 71052100
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##         ## ##  ## ##  #             #  ##          
AAH51194      16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQCqgdtvisecLQRFADSLQEVVNYHMNL 95  human
NP_001106491  16 RAAIDEVETDVVEIEAKLDKLVKLCSSMLEAGKTYLTTNKHFVSGIRDLSQQCkkdemisecLDKFGDSLQEMVNYHMIL 95  western clawed ...
XP_417581     16 RATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYITTNKHFVSGVRDLSQQCkkdemisecLDKFGDSLQEMINYHMIL 95  chicken
NP_001076484  16 RANIDEVETDVVEIEAKLDKLVKLCSGMIEAGRAYATANKLFVNGIRDLSHHCkkeemisecLEKCGESLQEIVNYHMIL 95  zebrafish
Feature 1                                                                                        
AAH51194      96 FDQAQRSVRQQLQSFVKeDVRKFKETKKQFDKVREDLELSLVRNAQAPRhrphevEEATGALTLTRKCFRHLALDYVLQI 175 human
NP_001106491  96 FDQAQRSVRQQLHMFVKdDVRKFKESKKQFDKVREDLDIALVKNAQAPRhkphevEEASSTLTITRKCFRHLALDYVLQI 175 western clawed ...
XP_417581     96 FDQAQRSVRQQLHNFVKdDVRKFKETKKQFDKVREDMEISLVKNAQAPRhkphevEEATGTLTITRKCFRHLALDYVLQI 175 chicken
NP_001076484  96 FDQAQRSVKQQLHSFVKeDVRKFKETKKQFDKVREDMEIAQVKNAQAPRnkphevEEATSTLITTRKCFRHLALDYVLQI 175 zebrafish
Feature 1        #  ## #    #  ## ##  ##  ## ##  ## ##   
AAH51194     176 NVLQAKKKFeiLDSMLSFMHAQSSFFQQGYSLLHQLDPYM 215 human
NP_001106491 176 NVLQAKKKFeiLDAMLSFMHAQYTFFQQGYSLLNELNPYM 215 western clawed frog
XP_417581    176 NVLQAKKKFeiLDAMLSFMHAQYTFFQQGYSLLHELDPYM 215 chicken
NP_001076484 176 NVLQAKKKFeiLDSMLSFMQAQYGLFHQGFNLLDEIDPYM 215 zebrafish

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