Conserved Protein Domain Family
BAR_GRAF

?
cd07636: BAR_GRAF 
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. GTPase Regulator Associated with Focal adhesion kinase (GRAF), also called Rho GTPase activating protein 26 (ARHGAP26), is a GAP with activity towards RhoA and Cdc42 and is only weakly active towards Rac1. It influences Rho-mediated cytoskeletal rearrangements and binds focal adhesion kinase (FAK), which is a critical component of integrin signaling. GRAF contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of GRAF directly interacts with its Rho GAP domain and inhibits its activity. Autoinhibited GRAF is capable of binding membranes and tubulating liposomes, showing that the membrane-tubulation and GAP-inhibitory functions of the BAR domain can occur simultaneously.
Statistics
?
PSSM-Id: 153320
View PSSM: cd07636
Aligned: 4 rows
Threshold Bit Score: 402.515
Threshold Setting Gi: 218546908
Created: 8-Jun-2009
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              #  ##   # ##  ## ##                                                   #
Q6ZQ82     19 RETLKSHEAELDKTNKFIKELIKDGKSLIS-------------------------------------------------A 49   house mouse
Q5ZMW5     19 RERLRSHEAELEKTNKFIKELIKDGKSLIA-------------------------------------------------A 49   chicken
B5DFQ4     19 RERLKSHEIELDKTNKFIKELIKDGKSLVA-------------------------------------------------A 49   western clawed frog
CAG11712   19 RDRLKSHELELDKTNKFIKELIKDGKALIQalkcfyeananspsrwdesrlmlerrgglrpssglwieawryrravlvdP 98   spotted green puf...
Feature 1     # ##  ## ##  #                          #  ##                                   
Q6ZQ82     50 LKNLSSAKRKFADSLNEFKFQCIGDAETDDEmciarsLQEFAAVLRNLEDERSRMIENASEVLITPLEKFRkeQIGAARE 129  house mouse
Q5ZMW5     50 LKNLSSAKRKFADSLNEFKFRCIGDAETDDEiciaksLQEFATVLRNLEDERMRMIENASEVLITPLEKFRkeQIGAAKD 129  chicken
B5DFQ4     50 HKNLSCAKRKFAGSLNEFKFRCIGDAETDDEiciarsLQEFAAVLGNLEDERIRMIDNSGEVLISPLEKFRkeQVGAAKE 129  western clawed frog
CAG11712   99 LTGLSTAKRKFAESLNEFKFQCIGDAETDDEiciaksLQEFAAVLQNLEDERTRMIENANDVLIMPLERFRkeQISAAKE 178  spotted green puf...
Feature 1                                                             #  ## #    #  ## ##   ##
Q6ZQ82    130 AKKKYDKETEKYCGTLEKhlnlsskkkesqlqeaDSQVDLVRQHFYEVSLEYVFKVQEVQERKMFefVEPLLAFLQGLFT 209  house mouse
Q5ZMW5    130 AKKKYDKETEKYCGVLEKhlnlsskkkesqlqeaDSQVDLVRQHFYEVSLEYVFKVQEVQERKMFefVEPLLAFLQGLFT 209  chicken
B5DFQ4    130 VKKKYDKESEKYCAMLEKhmnlsskkkevllheaDVQLDQMRQHFYEVSLEYVLKVHEVQERKMFefVEPLLAFLQGLFT 209  western clawed frog
CAG11712  179 AKKKYDKETEKYCAVLEKhlslsarkkeshlheaDSQVDSVRQHFYEVSLEYVFKVQEVQERKMFdfVEPLLAFLQGLFT 258  spotted green puf...
Feature 1       ## ## ## ##   
Q6ZQ82    210 FYHHGYELAKDFGDFK 225  house mouse
Q5ZMW5    210 FYHHGYELAKDFSDFK 225  chicken
B5DFQ4    210 FYHHGYELAKDFSDFK 225  western clawed frog
CAG11712  259 YYHHGYELAKDFNHFK 274  spotted green pufferfish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap