Conserved Protein Domain Family
BAR_GRAF2

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cd07635: BAR_GRAF2 
The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion 2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. GTPase Regulator Associated with Focal adhesion kinase 2 (GRAF2), also called Rho GTPase activating protein 10 (ARHGAP10) or PS-GAP, is a GAP with activity towards Cdc42 and RhoA which regulates caspase-activated p21-activated protein kinase-2 (PAK-2p34). GRAF2 interacts with PAK-2p34, leading to its stabilization and decrease of cell death. It is highly expressed in skeletal muscle and also interacts with PKNbeta, which is a target of Rho. GRAF2 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of the related protein GRAF directly interacts with its Rho GAP domain and inhibits its activity. Autoinhibited GRAF is capable of binding membranes and tubulating liposomes, showing that the membrane-tubulation and GAP-inhibitory functions of the BAR domain can occur simultaneously.
Statistics
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PSSM-Id: 153319
View PSSM: cd07635
Aligned: 4 rows
Threshold Bit Score: 414.395
Threshold Setting Gi: 118089875
Created: 8-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##  ## ##  ## ##  #                          #  ##    
BAB61771      19 RERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDErcidasLREFSNFLKNLE 98  human
NP_001089923  19 RERIRAHEAELDRTNRFIKDLLKDGKNLIAATKSLSAAQRKFAHSLRDFKFEFIGDAETDDErcidasLQEFSTFLQNLE 98  African clawed ...
NP_001038715  19 RDKIKAHEAELEKTGRFIKELYKDGKNLINATKQLSLAQKKFAQCLGEFKFEYIGDAKTDDEkcidesLQEFSLFLRNLE 98  zebrafish
XP_001232915  19 RERVRAHEAELERTNKFIKDLLKDGKNLIAATKNLSAAQRKFAHSLRDFKFEFIGDAETDDEryidasLHEFSNFLKNLE 98  chicken
Feature 1                                                                                        
BAB61771      99 EQREIMALSVTETLIKPLEKFRkeQLGAVKEEKKKFDKETEKNYSLIDKhlnlsakkkdshlqeaDIQVEQNRQHFYELS 178 human
NP_001089923  99 EQREIMALNVNETLVKPLERFRkeQLGGVKELKKKFDKETEKNYSLLDKhlslsakkkephlqeaDVQVEQNRQHFYQLS 178 African clawed ...
NP_001038715  99 EQRDLMMRNITETLMKPLENFRkeHLGSAKAERKKYEKETEKYYSSLEKllnmsakkkepqlqeaDVSVELMRQHFQETS 178 zebrafish
XP_001232915  99 EQREILALSVTETLIKPLERFRkeQLGAVKEEKKKFDKETEKNYSLLEKhlnlsakkkevqlqeaDNQVEQNRKHFYELS 178 chicken
Feature 1               #  ## #    #  ## ##   ##  ## ## ## ##   
BAB61771     179 LEYVCKLQEIQERKKFefVEPMLSFFQGMFTFYHQGHELAKDFNHYK 225 human
NP_001089923 179 LDYVCKLQEIQERKKFefVEPMLSFFQGIFTFYHQGYELANDFNHYK 225 African clawed frog
NP_001038715 179 LEYVCKLQEIQERKKFecVEPMLAFFQTVFTFYHQGYELAKDFDHYK 225 zebrafish
XP_001232915 179 LEYVCKLQEIQERKKFecVEPVLSFFQGLFTFYHQGYELAKDFSHYK 225 chicken

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