Conserved Protein Domain Family
BAR_GAP10-like

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cd07634: BAR_GAP10-like 
The Bin/Amphiphysin/Rvs (BAR) domain of Rho GTPase activating protein 10-like
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. This group is composed of uncharacterized proteins called Rho GTPase activating protein (GAP) 10-like. GAP10-like may be a GAP with activity towards RhoA and Cdc42. Similar to GRAF and GRAF2, it contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, a Rho GAP domain, and a C-terminal SH3 domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domains of the related proteins GRAF and OPHN1, directly interact with their Rho GAP domains and inhibit theiractivity. The autoinhibited proteins are capable of binding membranes and tubulating liposomes, showing that the membrane-tubulation and GAP-inhibitory functions of the BAR domain can occur simultaneously.
Statistics
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PSSM-Id: 153318
View PSSM: cd07634
Aligned: 3 rows
Threshold Bit Score: 426.754
Threshold Setting Gi: 47227146
Created: 8-Jun-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #  ##   # ##  ## ##  ## ##  ## ##  #                          #  ##    
A6NI28     19 RERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEisiaqsLKEFARLLIAVE 98   human
XP_417185  19 RERLKCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEiniaqsLKEFARLLIAVE 98   chicken
CAG00508   19 RERLQCHEIELERTNRFIKDLIKDGNMLVSALKSLSVAVQRFSQSLQDFQFECIGDAETDDEisiaqsLKEFSQLLSTVE 98   spotted green puf...
Feature 1                                                                                     
A6NI28     99 EERRRLIQNANDVLIAPLEKFRkeQIGAAKDGKKKFDKESEKYYSILEKhlnlsakk-----keshlqeaDTQIDREHQN 173  human
XP_417185  99 EERRRLIQNANDVLIAPLEKFRkeQIGAAKDGKKKFDKESEKYYSILEKhlnlsakk-----keshlqdaDTQIDREHQN 173  chicken
CAG00508   99 EERKRLIQNADDVLISPLERFRkeQIGAVKEGKKQFDKETERYYSVLEKhlslsskkkdshlqevklsrsVQLMFSDRQI 178  spotted green puf...
Feature 1                 #  ## #    #  ## ##   ##  ## ## ## ##   
A6NI28    174 FYEASLEYVFKIQEVQEKKKFefVEPLLSFLQGLFTFYHEGYELAQEFAPYK 225  human
XP_417185 174 FYEASLEYVFKIQEVQEKKKFefVEPLLAFLQGLFTFYHEGYELAQEFAPYK 225  chicken
CAG00508  179 FYDASLQYVFKIQEVQERKKFefVEPLLAFLQGLFTFYHEGYELAREFEPYK 230  spotted green pufferfish

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