Conserved Protein Domain Family
BAR_OPHN1

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cd07633: BAR_OPHN1 
The Bin/Amphiphysin/Rvs (BAR) domain of Oligophrenin-1
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Oligophrenin-1 (OPHN1) is a GTPase activating protein (GAP) with activity towards RhoA, Rac, and Cdc42, that is expressed in developing spinal cord and in adult brain areas with high plasticity. It plays a role in regulating the actin cystoskeleton as well as morphology changes in axons and dendrites, and may also function in modulating neuronal connectivity. Mutations in the OPHN1 gene causes X-linked mental retardation associated with cerebellar hypoplasia, lateral ventricle enlargement and epilepsy. OPHN1 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, and a Rho GAP domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153317
View PSSM: cd07633
Aligned: 4 rows
Threshold Bit Score: 397.067
Threshold Setting Gi: 122891160
Created: 8-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##  ## ##  ## ##  #                          #  ##    
AAI40764      19 RERLKCYEQELERTNKFIKDIIKDGNALISAMRNYSSAVQKFSQTLQSFQFDFIGDTLTDDEiniaesFKEFAELLNEVE 98  human
NP_001079992  19 RESLKGYEQELERTNKFIKDVIKDGNALISAIKGYSGAVQKFSQTLQSFQFDFIGDTMTDDEiniaesFKEFADLLQEVE 98  African clawed ...
CAM13477      19 RERLKCYENELEKTNKFLKDVIKDGNNVINTFKEYSLAVQKFSQTLQSFQFDFIGDTLTDDEmniaesFREFAGLLQDVE 98  zebrafish
XP_420161     19 RERLKCYEQELERTNKFIKDVIKDGNALIAAIRSYSSAVQKFSQTLQSFQFDFIGDTLTDDEiniaesFKEFAELLQEVE 98  chicken
Feature 1                                                                                        
AAI40764      99 NERMMMVHNASDLLIKPLENFRkeQIGFTKERKKKFEKDGERFYSLLDRhlhlsskkkesqlqeaDLQVDKERHNFFESS 178 human
NP_001079992  99 TERMMMLQNADDLLIKPLENFRkdQIGLTKERKKKFDKDSEKFYSLLDRhvnlsskkkevqlneaDQQVDREKQNFYESS 178 African clawed ...
CAM13477      99 EARMMLVQNASDLLIKPLEKFRkeQIGVTKERRKKFEKESEKYYSQLDKhvnlsskkketqlqeaDEQLDKERQAFYESS 178 zebrafish
XP_420161     99 LERSMMVQNASDLLIKPLENFRkeQIGFTKERKKKFEKDGEKFYSMLDRhlhlsskkkesqlqeaDLQVDKERHNFFESS 178 chicken
Feature 1               #  ## #    #  ## ##   ##  ## ## ## ##   
AAI40764     179 LDYVYQIQEVQESKKFniVEPVLAFLHSLFISNSLTVELTQDFLPYK 225 human
NP_001079992 179 LEYVYQIQEVQESKKFcvVEPVLTFLHCLFTSNNLTFELSQDFLPYK 225 African clawed frog
CAM13477     179 VEYVYQIQQVQEKKKFdvVEPVLAFLQSILTLNNLTVEMTQDFLPYK 225 zebrafish
XP_420161    179 LEYVYQIQEVQESKKFsiVEPVLAFLHSLFTYNNLTVELTQDFLPYK 225 chicken

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