2ELB,2Q13


Conserved Protein Domain Family
BAR_APPL1

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cd07631: BAR_APPL1 
Click on image for an interactive view with Cn3D
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 1
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing (APPL) proteins are effectors of the small GTPase Rab5 that function in endosome-mediated signaling. They contain BAR, pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. They form homo- and hetero-oligomers that are mediated by their BAR domains. Vertebrates contain two APPL proteins, APPL1 and APPL2. APPL1 interacts with diverse receptors (e.g. NGF receptor TrkA, FSHR, adiponectin receptors) and signaling proteins (e.g. Akt, PI3K), and may function as an adaptor linked to many distinct signaling pathways. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153315
View PSSM: cd07631
Aligned: 5 rows
Threshold Bit Score: 444.915
Threshold Setting Gi: 149241632
Created: 8-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceputative
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   #  #  ##  #         ## ##  ## ##  #                 #          
2ELB_A        40 RSLLGVFEEDATAISNYXNQLYQAXHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDevxssTLQQFSKVIDELSSC 119 human
2Q13_A        20 RSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDevmssTLQQFSKVIDELSSC 99  human
NP_001121546  20 RSLLGVFEEDAAAISSYFSQLFKAMQRIYDAQNELSAATHLTSKLLKDYEKQRFPLGGDDevmssTLQQFAKVIDELSSC 99  zebrafish
XP_414344    101 RSLLGVFEEDAAAISNYVNQLFQAMHRVYDAQNELSAATHLTSKLLKEYEKQHFPLGGDDeimssTLQQFAKVIDELSSC 180 chicken
NP_001083546  20 RSLLGVFEEDAAAISSYSNQLFHAMRRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDevmtsTLQQFSKVIDELSSC 99  African clawed ...
Feature 1                                                                                        
2ELB_A       120 HAVLSTQLADAXXFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRendKVKYEVTEDVYTSRKKQHQTXX 199 human
2Q13_A       100 HAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRendKVKYEVTEDVYTSRKKQHQTMM 179 human
NP_001121546 100 HAVLSTQLADAMMFPITQFQERDLREILILKEVFQLASDDHDAAVHRYSRLSKRKeneKVKNEVMEDVYTSRKKQHETTM 179 zebrafish
XP_414344    181 HAVLSTQLADAMMFPITQFKERDLKEILTLKEVFQIASNDHDAAITRYSRLSKRReneKIKAEVTEDVYTSRKKQHQTMM 260 chicken
NP_001083546 100 HAVLSTQLADAMMFPIGQFKERDLKEILTLKEVFQISSNDHDVAINRYSRLSKRReneKTKFEATEDVYTARKKQHQTMM 179 African clawed ...
Feature 1              #  ## #    ## ##  ## ##  ## ##   #  #            
2ELB_A       200 HYFCALNTLQYKKKIalLEPLLGYXQAQISFFKXGSENLNEQLEEFLANIGTSVQ 254 human
2Q13_A       180 HYFCALNTLQYKKKIalLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQ 234 human
NP_001121546 180 HYFASLNMLQYKKKIalLEPLLGYMQAQISFFKLGSENLTQQWEDFLTNIGTSVQ 234 zebrafish
XP_414344    261 HYFCALNTLQYKKKIavLEPLLGYMQAQISFFKMGSENLTEQLEEFLTNIGTSVQ 315 chicken
NP_001083546 180 HYFCALNTIQYKKKTaiLEPLLGYMQAQINFFKMGSENLNSQLEEFLSNIGSSVQ 234 African clawed frog

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