Conserved Protein Domain Family
BAR_Vps17p

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cd07625: BAR_Vps17p 
The Bin/Amphiphysin/Rvs (BAR) domain of yeast Sorting Nexin Vps17p
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. Vsp17p forms a dimer with Vps5p, the yeast counterpart of human SNX1, and is part of the retromer complex that mediates the transport of the carboxypeptidase Y receptor Vps10p from endosomes to Golgi. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153309
View PSSM: cd07625
Aligned: 10 rows
Threshold Bit Score: 356.307
Threshold Setting Gi: 19113959
Created: 18-May-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                 #  ##  ## ##  #  ##  #      ## ##  #  ##  ##           
NP_593047    224 GLKRKALKQFPLpPDPCQALANLRPIVKSFYKNAKDAEIKLEKLVNRKQSLALTHADLGQSLIDYSVEEqhn-------g 296 fission yeast
NP_985690    208 GLLRKTMKQRPPpYDEVTELAEFRPLVKSIYVVAQDVQAKLLRMTKTRKQLSHEESAFGQSFHQLTVEHdg--------- 278 Ashbya gossypii...
XP_454079    226 GLKRKTLKQLSPpYDETLALAEFRPLVKSIYHTTQEIKAKLLKMATVRRQLSQEVNQFGQAFQPLSLDNs---------- 295 Kluyveromyces l...
CAX44404     209 GIMRKTLKQFAVpYDPYEELANFRPIIKEAYLTLQKLHKLLDRNSKTEKQVSIHIFDMANKLSQLSEFEtthp------g 282 Candida dublini...
XP_001643018 205 GLKRKTLKQLSPpFDETLELAEFRPLVKSIHWTAKDLQLKLLRVSKAKKIVAENENAMGKGFISLSDYYkkfndetvssk 284 Vanderwaltozyma...
XP_503108    270 GLKRKAMKQWAPpLDDNAELRDFRPVVKALYNTGSDTVSKYERQCKIERQLALGLAELGHKTIACGDVLnpgaaalrsrd 349 Yarrowia lipoly...
CAP96725     245 GVRRKMLKQFAPpPDDTPELQAARPTAKMFYLGSMDSSHKVDRVVKARRGLGLAEADFGVKLGQMSVQEthp-------g 317 Penicillium chr...
XP_001526598 237 GLMRKTLKQFSVpYDPYEELAYYRPAVKSAYLICQKLHDLYKKSTKSEKQLSIHVYDMANKLSVLSEFEpshp------g 310 Lodderomyces el...
EDZ69273     239 GLKRKTLKQLAPpYDEITELAEFRPLVKSIYVVSQSLQEKLLRVSRNRKMMVQEENAFGQDFVNLDEHN----------- 307 Saccharomyces c...
XP_447566    228 GLKRKTMKQFAPpYDEYTELAEFRPLVKSIYSICDSIQERLLKASRARKLMVQDENLFGKCFEQIDDKN----------- 296 Candida glabrat...
Feature 1                   #                                                                    
NP_593047    297 laNALNRVGKMLQAISDVRIMQSSKQLVTLADSLCYASDNAFVVKEILSNRHILMRDLISSKNQTNSYLSAanrlqdspk 376 fission yeast
NP_985690    279 hsRLYQRFGKVLTAVGDLDSIMATFDMATLYDSLEWVVRDAYVVKETLTDRHFLMRDLLQAQSCTRLKQDAarrlrakrd 358 Ashbya gossypii...
XP_454079    296 --DLYHKFGRVITAIGDIESIVANLDMATLFDPLESIEHDSYIIKEALTNRHFVMRELLQAQQTSRQRQENarklrakrd 373 Kluyveromyces l...
CAX44404     283 mkNMWEKLGKITQKQSDFTLVDSINEMATLGDGTQTLIDDFYEIKEALTNRHLIMRELIQAETQTNVKHVQankiknkss 362 Candida dublini...
XP_001643018 285 qiTLYKHFGKIITTVGDFDSIIATVDIATFYDGLEWIINDTYVVKEALTNRHLIMRELIQAQQNTKSKQDNarrlrakrd 364 Vanderwaltozyma...
XP_503108    350 lgPVFAAFGQALVSVSDIAYARAAVQIASFVDPLDLVSQTGYVAKEQLTNRHLLMRELETLQTNAKNKHIAaerikisgq 429 Yarrowia lipoly...
CAP96725     318 lgAAYRKLGKIVQTVGDYHAVQATAEATTLGEPLSYHSSDAFIVKETLTNRHILLRDLLQAQQSARSKRAAadrlkvsss 397 Penicillium chr...
XP_001526598 311 mkNMWEKLSSVVLHQSDLLLVDSISGMAILGDGLLILINDFYEVKEALTNRYLIMRELIQAEAQTTSKHIHankikskas 390 Lodderomyces el...
EDZ69273     308 --KLYRRYGKILTAVGDIDSIIATMDMATLYDGLEWIVRDAYAVKEALTNRHFIMRNLVQAQQNSKAKQEQarrfrsrrd 385 Saccharomyces c...
XP_447566    297 --VLYKKYGRVMTAVGDIDSIIASMDMATFYDGLTWIVRDTYVVKEALTNRHFLMRELLNAQANTKNRQEQvrktrtkrd 374 Candida glabrat...
Feature 1                                              #  ## ###  #  ## ### ##  ## ##  ## ##  
NP_593047    377 iskartddalqalevARVHEKLLSDKVDFVTLNLVKESKTYTKKTSVSLQKAIREYVEKEAYYERRLLSIMESIRPH 453 fission yeast
NP_985690    359 isplkvddaiqqlklATKTEHDLSRRLQRVTANMRIERSRWVDNLSNSLLAAVREYTLRKIEYERKKLSLLERVRAD 435 Ashbya gossypii AT...
XP_454079    374 inplkvdesirqlkeSTKNEHDLTIKLKRITANMLIERERWLVYLQETLAQAIKEFVLRKIEYDRKKLSLLERIRLT 450 Kluyveromyces lact...
CAX44404     363 ldpikvdealrsleyASKVQESLHLQVKRISGEMMFERKEVIDFTEKRIQRLMKAYTLHKVEHHRKILKHFENIRLD 439 Candida dubliniens...
XP_001643018 365 inpikvdeairqlkeATRYEQQLTLKLERVTTNMLLERKEWLNWYEEHLKSIIKEYTLKRIEYERKKLSILEKVRSD 441 Vanderwaltozyma po...
XP_503108    430 hnphkvdeaialyeeATRAETRLSNRLKRISDALCIGKTKLTKNVEEDLTQAVREVTQRVIECERRTLAVWENIRGD 506 Yarrowia lipolytic...
CAP96725     398 vrpdkvdeainaleeAQNHEDYLTKRTQRVTSNLLQEKRRWFDRTTHDLLFSLREYTLRQIEAERRTLATLESVRPD 474 Penicillium chryso...
XP_001526598 391 ldplkvdealrsleyATKIQSSLNLQVKRISGEMIYEKEEFNNFVDAKFRELIKKSVLRKVEHHRKVLNSFEKIRLD 467 Lodderomyces elong...
EDZ69273     386 inpmkidealrqlkaATKNEQVLTLKLQRITSNMIIERKQWISWYEEWIRSSIKEFTLRKIEYERKKLTLLERVRSD 462 Saccharomyces cere...
XP_447566    375 snpikveettrnmklAHQYEADVSQKLNRVTQNMLIERNEWLSWYDKWLKSCIRSYVLKRIEYERKKLALLERVRID 451 Candida glabrata C...

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