Conserved Protein Domain Family
BAR_SNX1_2

?
cd07623: BAR_SNX1_2 
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 1 and 2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. This subfamily consists of SNX1, SNX2, and similar proteins. SNX1 and SNX2 are components of the retromer complex, a membrane coat multimeric complex required for endosomal retrieval of lysosomal hydrolase receptors to the Golgi. The retromer consists of a cargo-recognition subcomplex and a subcomplex formed by a dimer of sorting nexins (SNX1 and/or SNX2), which ensures efficient cargo sorting by facilitating proper membrane localization of the cargo-recognition subcomplex. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
?
PSSM-Id: 153307
View PSSM: cd07623
Aligned: 20 rows
Threshold Bit Score: 277.618
Threshold Setting Gi: 157753306
Created: 15-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #  ##    ## ##  #  ##  #      ## ##  #  ##  ##  
NP_001012625 292 NKMTIKMN-------------ESDAWFEEKQQQFENLDQ--QLKKLHASVEALVCHRKELSANTAAFAKSAAMLGNSEDH 356 chicken
XP_001120260 285 NKITYKMD-------------ETDKWFEEKTSQIEIDSLdvQLRALHSAVDTLTNQRRELATCTGATARSIAVLGHGEPG 351 honey bee
EEC15214     167 SKITTKMD-------------ETDPWFEEKQQQVDNLDL--QLRRLHASIETMVQQRRELSQSTGSFAKSAAMLGNCEEH 231 black-legged tick
XP_001945839 286 NKITYKMD-------------ENEPWFEEKEVQIENLDL--QLRNLHGAVETLVINRKELAHSSGSFAKSAAVLSNCEEH 350 pea aphid
XP_002130718 295 SKITIKMT-------------EEDSWFEEKQQQIESLEQ--QLRKLHASFESLVHHRKELAVNTALFAKSSATLGNAEEH 359 Ciona intestinalis
EEB15745     275 NKITFKMEekdsvsflhgfylTYHLFSEIKSSQIDNLDI--QLRKLHASVESLVMHRRELAELTSSFAKSAALLSSCEQH 352 human body louse
XP_001680365 127 DKITIPIE-------------ETDQWFEKANSSWEELDE--NLRKLHAEAVGLVQHRKAMALNGEMLAKSLSSLAASEDS 191 Caenorhabditis ...
NP_508216    243 SKMAFHME-------------EGDRWFEQVQSQVDELDE--ALRKLYTVTETLVASRRDMATSGEQLGKALSMLAACEES 307 nematode
XP_001898646 218 SKMAFHMD-------------ENDRWFEAAQQQMEDMEQ--NLSKLLRAVESLSSYRRELISGTDSFSKALSMLSSCEEN 282 agent of lympha...
XP_001913313 249 KQVTQKMP-------------ETDSWFEDRAASVDNLQA--QLKRLSMASGNLSVHRRELGLSSGNLARASNMLANAEDK 313 Oikopleura dioica
Feature 1                     #                                                                  
NP_001012625 357 TALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLGDYIRLIAAVKGVFDHRMKCWQKWQDAQVTLQKKREAeaklqla 436 chicken
XP_001120260 352 ASLGRALAQLAETLEKVEVIRRAQSNSDLYQFGEMLRDYVALIGAIKDVFHERVKVFQNWQHAQMMLNKKREQkarleqs 431 honey bee
EEC15214     232 TGLSRALSKLAEVCERVEQVQGRQAKQDFYCLAELVKDYVSLVGAIKEALHQRVKVYGTWQHAQQTLARKREAkaklela 311 black-legged tick
XP_001945839 351 TGLSRALSQLADVFEKVESVRTEQANTDFSIFCELLKDYIGLIGAVKNVFHERVKVYQNMQHAQMILTKKREQktklelt 430 pea aphid
XP_002130718 360 TALSRALAQLSDAFEKIENVHQEQSNTDYYAVAETLADYLRIITEIKEIFMVRVKSWQNWQNAEQNVQRKKEAeakmqas 439 Ciona intestinalis
EEB15745     353 DALSRALSQLAYVEDKVEVLYNNQANSDFSILCELLNDYVALIGAIKDVFHERVKVYQIWQHAQLMLTKKRELkskfelq 432 human body louse
XP_001680365 192 TTLSLALTSLTDTYEQSASIWSRQAEEHNAKFAEAVEEYLGLLESIRDVVAERIHVWQQWKKAQKTLEELRSKlstvddl 271 Caenorhabditis ...
NP_508216    308 TSLSRALSSLTDVTENVSAVYGKQAEVDNSKFSESIYEYIMLISALKDVFGERVRAWQQWQDAQQTLARKRDQktkidls 387 nematode
XP_001898646 283 TTLARCLSHLTETYENIDQLHGVQSDKDCALLAEGISEQLQIIYTLKELFFERVKIWQNWQAAQQNLTRKREMkarhels 362 agent of lympha...
XP_001913313 314 QDLSRRLANVGTIYENLGEIYTDLSDKDLYDFSELLSDQVRGLDGIKNILEARQKMWQNWQSSEQGLMKKRDTvtrlqat 393 Oikopleura dioica
Feature 1                                                #  ## ###  #  ## ### ##  ## ##  ## ##   
NP_001012625 437 nkpd--klqqakdeikeWESKVQQGEKDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEA 514 chicken
XP_001120260 432 grtd--ktsqaatevieWEAKVDRGQEEFDNISKMIKKELERFELVRVEDFKKQLTEYLESMLQYQNQLIKYWESFLPEA 509 honey bee
EEC15214     312 qkad--rlpqarqevldWEAKVDRAQEEFDSVSRVIRAELDRFELDRIADFRASVVRYLEFLLDTQQQLIKYWETFLPEA 389 black-legged tick
XP_001945839 431 grld--kvgfvtnevseWEAKLSRCQDEFDQISKTIKVEFEQFEINRIKEFKTVISSYLEEMINHQTLIIKHWQAFIPEA 508 pea aphid
XP_002130718 440 grtd--kiaqiqadikeLEARVQTCKSDFDELSAEIKKEMQAFEQDRVVDFRQLVLIFLKNLMKSQEQNIKNWEAFMPEA 517 Ciona intestinalis
EEB15745     433 erre--ksaqvaneiieWNAKVERGQKEFDNISHMIKKEMERFEINRVKEFKIIIIQYLETIMNRQQELIKHWEGFLPEA 510 human body louse
XP_001680365 272 kv------kelnreiqeTNEAKERLQKEFDEMSKAIKVEIERFEEERQEDMKHILVDFIQNMIQSHIQIAELWDQFAPYA 345 Caenorhabditis ...
NP_508216    388 aggrnersdqlkgeiedTVQKMDQLEQHFIELSKAIREEVARFDADRKQDMKKMLVEYMESMIHTHTELLHLWEKFEPEA 467 nematode
XP_001898646 363 grtd--rtnqiiaelnsAEKAVDEVEKEFSEVSKVIRGEYETFLVERKNDMNDTFKQYLQELLETQKQFLKCWEIFAPET 440 agent of lympha...
XP_001913313 394 grte--kipgaeleikeWETKAATSKKGFEDMTAVAKKEINTWETQRVAETKMFILKWMKHMLEAEKKVVAMWEKYLPKA 471 Oikopleura dioica
Feature 1         
NP_001012625 515 K 515 chicken
XP_001120260 510 R 510 honey bee
EEC15214     390 K 390 black-legged tick
XP_001945839 509 K 509 pea aphid
XP_002130718 518 R 518 Ciona intestinalis
EEB15745     511 K 511 human body louse
XP_001680365 346 Q 346 Caenorhabditis briggsae AF16
NP_508216    468 N 468 nematode
XP_001898646 441 Q 441 agent of lymphatic filariasis
XP_001913313 472 Q 472 Oikopleura dioica

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap