Conserved Protein Domain Family
BAR_Rich2

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cd07619: BAR_Rich2 
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. RhoGAP interacting with CIP4 homologs protein 2 (Rich2) is a Rho GTPase activating protein that interacts with CD317, a lipid raft-associated integral membrane protein. It plays a role in actin cytoskeleton organization and the maintenance of microvilli in polarized epithelial cells. Rich2 contains an N-terminal BAR domain followed by a GAP domain for Rho and Rac GTPases and a C-terminal proline-rich domain. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153303
View PSSM: cd07619
Aligned: 4 rows
Threshold Bit Score: 494.95
Threshold Setting Gi: 47213831
Created: 3-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  ##      # ##  ## ##                                ## ##  ## ##  #   
Q17R89     13 NQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHsthkkltaclQGQQGAEADKRSKk-----lPLTTLAQCLMEGSAILGD 87  human
XP_425368  13 NQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHsthkkltaclQGQQGVDADKRSKk-----lPLTTLAQCLTEGSAVLGD 87  chicken
CAG00635   57 QPQIIRAEKTEVLSEDLLQVEKRLELVKQVSHsthkkltaclQGQQSVDVDKKSVrspskklPLTTLAQCMVEGAAVLGD 136 spotted green puff...
XP_695681  18 MFEDLGAEKTEVLSEDLLQVEKRLDLVKQVSHsthkkltaclQGQQGTEIEKRSKk-----lPLTTLAQCMVEGAAVLGD 92  zebrafish
Feature 1               #  ##                                                                 
Q17R89     88 DtllgkmlkLCGETEDKLAQELIHFELQVERDVIEPLFLLAe-------------------------------------- 129 human
XP_425368  88 DsllgkmlrLCGEAEDKLAQELIQFELQVERDVIEPLFVLAe-------------------------------------- 129 chicken
CAG00635  137 EsllgkmlkLCGETQHKLAQELILFEMTIERDVVEPLYDLSevspggsarrrtgwrkqtrrswlsvavcsfvcsmkkgtv 216 spotted green puff...
XP_695681  93 DsllgkmlkLCGDTEEKLAQELLVFELQIERDVVEPLYVLAe-------------------------------------- 134 zebrafish
Feature 1                                                                                 #  #
Q17R89    130 ---vEIPNIQKQRKHLAKLVLDMDSSRTRWQQtskssgls-sslqpagAKADALREEMEEAANRVEICRDQLSADMYSFV 205 human
XP_425368 130 ---vEIPNIQKQRKHLAKLVLDMDSSRTRWQQsakssgls-snlqpsgAKADALREEMEEAANRVEICRDQLSADMYSFV 205 chicken
CAG00635  217 lsqvEIPNIQKQRKHLAKLVLHMDSPRTRWYFqstkssglssnlqptgAKADHLREEMEEAANRMEICRDQLSADMYSFV 296 spotted green puff...
XP_695681 135 ---vEIPNIQKQRKHLAKLVLDMDSARTRWQQsskssghp-snvqqggAKSDSLREEMEETANRMEICRDQLSADMYNFV 210 zebrafish
Feature 1     # #   #  ## ##  ##  ## ##  ## ##                       
Q17R89    206 AKEiDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEH 260 human
XP_425368 206 AKEiDYANYFQTLIEVQAEYHRKSLALLQSVLPQIKAQQEAWMEKPSFGKPLEEH 260 chicken
CAG00635  297 AKEiDYASYFQTLIEVQAEYHRKSLELLQSMLPQIKAHQESWVEKPCYGKPLEEH 351 spotted green pufferfish
XP_695681 211 AKEiDYANYFQTLIEVQAEYHRKSLEILQSVLPQIKAHQEAWIEKPSYGKALEEH 265 zebrafish

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