Conserved Protein Domain Family
BAR_Rich1
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cd07618: BAR_Rich1 
The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. RhoGAP interacting with CIP4 homologs protein 1 (Rich1) is also called Neuron-associated developmentally-regulated protein (Nadrin) or Rho GTPase activating protein 17 (ARHGAP17). It is a Cdc42- and Rac-specific GAP that binds to polarity proteins through the scaffold protein angiomotin and plays a role in maintaining the integrity of tight junctions. It may be a component of a sorting mechanism in the recycling of tight junction transmembrane proteins. Rich1 contains an N-terminal BAR domain followed by a Rho GAP domain and a C-terminal proline-rich domain. It interacts with the BAR domain proteins endophilin and amphiphysin through its proline-rich region. The BAR domain of Rich1 forms oligomers and can bind membranes and induce membrane tubulation.
Links
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Statistics
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PSSM-Id: 153302
Aligned: 3 rows
Threshold Bit Score: 496.864
Created: 3-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  ##      # ##  ## ##                           ## ##  ## ##  #        
Q99N37        13 NQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHhshkrliacfQGQHGTDAERRHKklPLTALAQNMQEASAQLEESllgk 92  Norway rat
XP_414864     13 NQTVGRAEKTEVLSEDLLQIERRLDTVRSVFHiaqkrliacfQGQYGTDPDKRHKklPLTALAQNMQEGSAQLSDEtllg 92  chicken
NP_001108378  13 NQTVGRAEKTEVLSDDLLLIERRLENVRLVSHnvhkkmvmclQGNVGTDAEKRHKklPLMILSQSMVEGVAQLGEEslig 92  zebrafish

Feature 1             #  ##                                                                      
Q99N37        93 -mleTCGDAENQLAFELSQHEVFVEKEIMDPLYGIAevEIPNIQKQRKQLARLVLDWDSVRARWNQahkssgt--nfqgl 169 Norway rat
XP_414864     93 kmldTCGDAENKLALELSQHEVQIEKDILEPLNTLTevEIPNIQKQRKQLAKLVLDWDSARGRYNQahktsgt--nfqmh 170 chicken
NP_001108378  93 kmmdICGDAENKLAFEQSQHEVLLEKDILDPLNQLAevDIPNIQKQRRHLAKLVLDYDSAKGRYHQatksfpsatnaqam 172 zebrafish

Feature 1                                     #  ## #   #  ## ##  ##  ## ##  ## ##               
Q99N37       170 pSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEgEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQDKWAEKPA 249 Norway rat
XP_414864    171 pSKIDSLKEEMDEAGNKVEQCKDQLAADMYNFVSKEgEYAKFFVMLLEAQADYHRKALAVIEKVLPEIQAHQDKWTEKPA 250 chicken
NP_001108378 173 aAKVDMLKEEMDEAQNRMEICKDQVAADMYSFASKEgEYARYYVLLLEAQAEYHRRALASIESVLPNIQSQQDKWMEKPA 252 zebrafish

Feature 1                
Q99N37       250 FGTPLEEH 257 Norway rat
XP_414864    251 FGTPLEEH 258 chicken
NP_001108378 253 FGTALEEH 260 zebrafish

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