Conserved Protein Domain Family
BAR_Endophilin_B2

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cd07617: BAR_Endophilin_B2 
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition, and endosomal sorting. Endophilins contain an N-terminal N-BAR domain (BAR domain with an additional N-terminal amphipathic helix), followed by a variable region containing proline clusters, and a C-terminal SH3 domain. They are classified into two types, A and B. Vertebrates contain two endophilin-B isoforms. Endophilin-B proteins are cytoplasmic proteins expressed mainly in the heart, placenta, and skeletal muscle. Endophilin-B2, also called SH3GLB2 (SH3-domain GRB2-like endophilin B2), is a cytoplasmic protein that interacts with the apoptosis inducer Bax. It is overexpressed in prostate cancer metastasis and has been identified as a cancer antigen with potential utility in immunotherapy. Endophilin-B2 forms homo- and heterodimers (with endophilin-B1) through its BAR domain, which can bind and bend membranes.
Statistics
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PSSM-Id: 153301
View PSSM: cd07617
Aligned: 4 rows
Threshold Bit Score: 408.648
Threshold Setting Gi: 41055363
Created: 1-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interfaceputative
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #  ##   # ##  ## ##                          ## ##  ## #
Q8R3V5        21 QFTEEKFGQAEKTELDAHFENLLARADSTKNWTERILRQTEVLLQPNPSARVEEFlyekldrkvpsRVTNGELLAQYMAE 100 house mouse
NP_957413     21 QYTEEKLGQAEKTELDAHLENLIARADCTKNWTEKIFRQTEVLLQPNPSARIEEFfyekldkkipsRITNAELLGQYMQD 100 zebrafish
NP_001087774  21 QFTQENLGQAEKTELDAHFENLLTRADNTKNWTEKILHQTEVLLQPSPSARVEEFlyekldrkapsRVTTAELLGQYMTE 100 African clawed ...
NP_001006200  21 QFTEEKLGQAEKTELDAHFENLLARADSTKNWTEKILRQTEVLLQPNPSARVEEFlyekldrkvpsRVTNGELLAQYMTE 100 chicken
Feature 1        #  #             #  ##                                                          
Q8R3V5       101 AASELGPSTPYGKTLIKVSEAEKRLGAAERDFIHTASLSFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAk 180 house mouse
NP_957413    101 AAKDFGPGSPYGSTLITVGEYQKRLGGSEREFLQTSAINFLTPLRNFLEGDWKTISRERRLLENRRLDLDVCKARLKKAk 180 zebrafish
NP_001087774 101 AANDFGPSTPYGQTLIKVGDTQKHLGAAERDFIHSSSINFLTPLRNFLEGDWKTIAKERRILQNRRLDLDACKARLKKSk 180 African clawed ...
NP_001006200 101 AANDFGPGTPYGKTLIKVGETQRRLGAAERDFIHSASINFLTPLRNFLEGDWRTISKERRILQNRRLDLDACKARLKKAk 180 chicken
Feature 1                                                                       #  ## #   #  ## #
Q8R3V5       181 aaeakattvpdfqetrpr----nyilsasasalwndevdkaEQELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF 256 house mouse
NP_957413    181 laea---------------------------------kaaaEHELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF 227 zebrafish
NP_001087774 181 aaeakaalegdalpdfqetrprnyilsasasalwsdevdkaEHELRVAQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF 260 African clawed ...
NP_001006200 181 aaeakaaavpdfqetrpr----nyvlsasasalwsdevekaEHELRLTQTEFDRQAEVTRLLLEGISSTHVNHLRCLHEF 256 chicken
Feature 1        #  ##  ## ##  ## ##   
Q8R3V5       257 VKSQTTYYAQCYRHMLDLQKQL 278 house mouse
NP_957413    228 VEAQAAYYAQCHRHMQDLQKEL 249 zebrafish
NP_001087774 261 AEAQATYFAQSYQYMLDLQKQL 282 African clawed frog
NP_001006200 257 VESQTNYYAQCYQYMLDLQKQL 278 chicken

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