Conserved Protein Domain Family
BAR_Endophilin_B1

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cd07616: BAR_Endophilin_B1 
The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B1
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition, and endosomal sorting. Endophilins contain an N-terminal N-BAR domain (BAR domain with an additional N-terminal amphipathic helix), followed by a variable region containing proline clusters, and a C-terminal SH3 domain. They are classified into two types, A and B. Endophilin-B proteins are cytoplasmic proteins expressed mainly in the heart, placenta, and skeletal muscle. Endophilin-B1, also called Bax-interacting factor 1 (Bif-1) or SH3GLB1 (SH3-domain GRB2-like endophilin B1), is localized mainly to the Golgi apparatus. It is involved in the regulation of many biological events including autophagy, tumorigenesis, nerve growth factor (NGF) trafficking, neurite outgrowth, mitochondrial outer membrane dynamics, and cell death. Endophilin-B1 forms homo- and heterodimers (with endophilin-B2) through its BAR domain, which can bind and bend membranes. It interacts with amphiphysin 1 and dynamin 1 through its SH3 domain.
Statistics
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PSSM-Id: 153300
View PSSM: cd07616
Aligned: 4 rows
Threshold Bit Score: 456.843
Threshold Setting Gi: 62955203
Created: 1-Jun-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interfaceputative
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                #  ##   # ##  ## ##                          ## ##  ## #
Q9Y371        24 QFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFvyekldrkapsRINNPELLGQYMID 103 human
NP_001085431  21 QFTEEKFGQAEKTELDAHLENLLAKAECTKVWTEKIMKQTEVLLQPNPNARIEEFvyekldrkapsRLNSEEQLAQYMSD 100 African clawed ...
NP_001017617  21 QFTEEKFGQAEKTELDAHLETLLTRAECTKHWTEKILKQTEVLLQPNPNARIEELlyekldkkappRMNNHELMGQSMID 100 zebrafish
NP_001006534  24 QFTEEKLGQAEKTELDAHLENLLSKAECTKQWTEKIMKQTEVLLQPNPNARIEEFfyekldrkapsRMNNPELLGQYMID 103 chicken
Feature 1        #  #             #  ##                                                          
Q9Y371       104 AGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAk 183 human
NP_001085431 101 AGNEFGPGTAYGNALIKCGETQKRIGVAHRELIQTAAINFLTPLRNFIEGDYKTMTKEKKLLQNKRLDLDAAKTRLKKAr 180 African clawed ...
NP_001017617 101 SGNEFGPGTAYGNALIKCGETEKQIGGAEREFIQTSAINFLTPFRNFLEGDFKTILKERKLLQNKRLDLDAAKTKLKKAk 180 zebrafish
NP_001006534 104 AGNEFGPGTAYGNALIKCGETQKQIGTADRELIQTSAINFLTPLRNFIEGDYKTITKERKLLQNKRLDLDAAKTRLKKAk 183 chicken
Feature 1                                      #  ## #   #  ## ##  ##  ## ##  ## ##   
Q9Y371       184 aaetrnssEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQL 252 human
NP_001085431 181 vtearaaaEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYFAQSYQYMLDLQKQL 249 African clawed frog
NP_001017617 181 madaravaEQDLKMTQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMVDLQKQL 249 zebrafish
NP_001006534 184 vaearaasEQEVRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYKYMLDLQKQL 252 chicken

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