Conserved Protein Domain Family
BAR_Bin2

?
cd07612: BAR_Bin2 
The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 2
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Bridging integrator 2 (Bin2) is a BAR domain containing protein that is mainly expressed in hematopoietic cells. It is upregulated during granulocyte differentiation and is thought to function primarily in this lineage. The BAR domain of Bin2 is closely related to the BAR domains of amphiphysins, which function primarily in endocytosis and other membrane remodeling events. Amphiphysins contain an N-terminal BAR domain with an additional N-terminal amphipathic helix (an N-BAR), a variable central domain, and a C-terminal SH3 domain. Unlike amphiphysins, Bin2 does not appear to contain a C-terminal SH3 domain. Amphiphysin I proteins, enriched in the brain and nervous system, function in synaptic vesicle endocytosis. Some amphiphysin II isoforms, also called Bridging integrator 1 (Bin1), function in intracellular vessicle trafficking. Bin2 can form a stable complex with Bin1 in cells but cannot replace the function of Bin1, and thus, appears to harbor a nonredundant function. The N-BAR domain of amphiphysin forms a curved dimer with a positively-charged concave face that can drive membrane bending and curvature.
Statistics
?
PSSM-Id: 153296
View PSSM: cd07612
Aligned: 5 rows
Threshold Bit Score: 384.592
Threshold Setting Gi: 55925429
Created: 20-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
dimer interfaceputative
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                           #  ##   #  #  ##  #         ## ##  ## ##  #       #          
Q803I3        38 QKLGKTMETKDEQFEECSANLNKQQTDGIRLYKDVKAYYNAVKVMHESSKRLSQTLKDIYEPDWhGVEDLTVIMESEDLL 117 zebrafish
BAH13239       4 QKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVMHESSKRVSETLQEIYSSEWdGHEELKAIVWNNDLL 83  human
NP_001007422  34 QRLGKSEETKDEHFEQCVMNLHMQQSDGYRIYKDLKAYLNAVTVMRDASSRLFQSLFDAYDDRWdGGQDLGEVVEGEDLL 113 zebrafish
NP_001074365  28 QKLGKTVETKDEQFEQSAYNFQLQQNEGNKLYKDLKAFVGAVKVMHESSRKVAETLQEIYSTEWdGHVELKAIADSNDLL 107 chicken
ACN10513      31 QKFGKTVETKDEIFEQCLLNLNDQQIVGNRLYKDLKIYLSSVKGMREASKHLSQSLYGVYEPDWdGKEDLGTIVEGEDDL 110 Atlantic salmon
Feature 1                                                                                        
Q803I3       118 WNDYEEKLNDQVVRTMENYTA---------------------------QFQDVKERVAKRGRKLVDYDSTRHHLEALQSA 170 zebrafish
BAH13239      84 WEDYEEKLADQAVRTMEIYVA---------------------------QFSEIKERIAKRGRKLVDYDSARHHLEAVQNA 136 human
NP_001007422 114 WKDYESKLHDQALITMESYMS---------------------------QFPDVRDRVAKRNRKLVDYDSARHQLTGLQNA 166 zebrafish
NP_001074365 108 WDDYEAKLGDQALRLMENYLA---------------------------QFGDIKERIAKRGRKLVDYDSARHHLEALQNA 160 chicken
ACN10513     111 WNDYEANLIDKALCTMESYISqfpdvrvrmeththtlpkylishvrysFTPTPQERVAKRGRKLVDYDSSRHHLEAMQNA 190 Atlantic salmon
Feature 1                                         #  ## #    ## ##  ## ##  ## ##   #  #        
Q803I3       171 kkrDDAKVNKAEEEFNKAQEVFEDINKELREELPVLYQSRISCYVTMFQNISNLRDVFYKEMSMLNHNIYNMMKKLED 248 zebrafish
BAH13239     137 kkkDEAKTAKAEEEFNKAQTVFEDLNQELLEELPILYNSRIGCYVTIFQNISNLRDVFYREMSKLNHNLYEVMSKLEK 214 human
NP_001007422 167 kkrDDIKIGKAEDEMNAAKVIFEDMNRELKMELPILFDSRIGCYVTVFQAVCSLRETFYKEITKNNDVLQTVMKELSA 244 zebrafish
NP_001074365 161 kkkDEAKIAKAEEEFNRAQVVFEELNRELREELPVLYGSRIACYVTIFQNISNLRDIFYKEMSKLNRDLYEVMGKLDK 238 chicken
ACN10513     191 kkkDDVKIAKAAEEVNRTQIVFEDINRELRDELPTLYDSRIGCYVSVFTAISNLRDTFFKEIITFNGDLQNVMKGLKD 268 Atlantic salmon

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap