2V0O,2V0O,3HAI,3HAJ,2EFL,3G9G


Conserved Protein Domain Family
FCH_F-BAR

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cd07610: FCH_F-BAR 
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The Extended FES-CIP4 Homology (FCH) or F-BAR (FCH and Bin/Amphiphysin/Rvs) domain, a dimerization module that binds and bends membranes
F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization. F-BAR domain containing proteins, also known as Pombe Cdc15 homology (PCH) family proteins, include Fes and Fer tyrosine kinases, PACSINs/Syndapins, FCHO, PSTPIP, CIP4-like proteins and srGAPs. Many members also contain an SH3 domain and play roles in endocytosis. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules. These tubules have diameters larger than those observed with N-BARs. The F-BAR domains of some members such as NOSTRIN and Rgd1 are important for the subcellular localization of the protein.
Statistics
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PSSM-Id: 153294
View PSSM: cd07610
Aligned: 20 rows
Threshold Bit Score: 96.2546
Threshold Setting Gi: 259090188
Created: 14-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:2V0O_AB; interface between monomers in human FCHO2 F-BAR dimer; defined at 4A contacts.
    View structure with Cn3D
  • Structure:3HAJ_AB; interface between monomers in human Pacsin2 F-BAR dimer; defined at 4A contacts.
    View structure with Cn3D
  • Structure:3HAI_AB; interface between monomers in human Pacsin1 F-BAR dimer; defined at 4A contacts.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1      #  #      #  ##  #  ##  ##  #   #  #   #                                       #
2V0O_A      19 GFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSasnysqlg----------------tfapvwdvFKTST 82   human
Q91Z69      31 QQKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKLAERfmaktrstkdhqqfkkdqnllspvncwylllnQVRRE 110  house mouse
2V0O_B      19 GFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSasnysqlg----------------tfapvwdvFKTST 82   human
3HAI_A      28 TVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLiekgpq--------------------ygslerAWGAI 87   human
3HAJ_A      27 TVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLvekgpq--------------------ygtvekAWMAF 86   human
2EFL_A      15 QFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKyqpkknskeeee---------ykytsckafisNLNEX 85   human
NP_593322   33 GMDALMSRTKSSLSVLESIDEFYAKRASIEREYASKLQELAASsadipevg-----------------stlnnilSMRTE 95   fission yeast
EED46620    55 GITTLLTRLKQSVASARDFSTFLKKRSSLEEEHAQGLRKLSRSlldasvrtdn------------rqgtygqshnDLSRF 122  Aspergillus flav...
P07332      12 GHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQdsggqsrais------------pdspisqswaEITSQ 79   human
NP_055639   21 QMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQylkrdwpgvkadd-------rndyrsmypvwkSFLEG 93   human
Feature 1        #                                                                             
2V0O_A      83 EKLANCHLDLVR---------KLQELIKEVQKYGEEQVKShk-----kTKEEVAGTLEAVQTIQSITQALQKskenynak 148  human
Q91Z69     111 SKDHATLSDIYLnnv----imRFMQISEDSTRMFKKSKEIafql-hedLMKVLNELYTVMKTYHMYHSESISaesklkea 185  house mouse
2V0O_B      83 EKLANCHLDLVR---------KLQELIKEVQKYGEEQVKShk-----kTKEEVAGTLEAVQTIQSITQALQKskenynak 148  human
3HAI_A      88 MTEADKVSELHQe--------VKNNLLNEDLEKVKNWQKDayhkqimgGFKETKEAEDGFRKAQKPWAKKMKeleaakka 159  human
3HAJ_A      87 MSEAERVSELHLe--------VKASLMNDDFEKIKNWQKEafhkqmmgGFKETKEAEDGFRKAQKPWAKKLKeveaakka 158  human
2EFL_A      86 NDYAGQHEVISEn--------XASQIIVDLARYVQELKQE--------RKSNFHDGRKAQQHIETCWKQLESskrrferd 149  human
NP_593322   96 TGSMAKAHEEVSq--------QINTELRNKIREYIDQTEQq-------KVVAANAIEELYQKKTALEIDLSEkkdayeys 160  fission yeast
EED46620   123 HDRMADHGLQFAv--------SLQQMADSLHELAANIERG--------RKQWKQTGLSAEKRVMEAEAAAEKakakyesl 186  Aspergillus flav...
P07332      80 TEGLSRLLRQHAedlnsgplsKLSLLIRERQQLRKTYSEQwqqlqqelTKTHSQDIEKLKSQYRALARDSAQakrkyqea 159  human
NP_055639   94 TMQVAQSRMNICe--------NYKNFISEPARTVRSLKEQq-------LKRCVDQLTKIQTELQETVKDLAKgkkkyfet 158  human
Feature 1                                                       #   #                         #
2V0O_A     149 cveqerlkk----------------------egatqreiekaavkskKATDTYKLYVEKYALAKADFEQ-KMTETAQKFQ 205  human
Q91Z69     186 ekqeekqi-----------------------grsgdpvfhirleerhQRRSSVKKIEKMKEKRQAKYSE-NKLKSIKARN 241  house mouse
2V0O_B     149 cveqerlkk----------------------egatqreiekaavkskKATDTYKLYVEKYALAKADFEQ-KMTETAQKFQ 205  human
3HAI_A     160 yhlackeeklamtremnskteqsvtpeqqkklqdkvdkckqdvqktqEKYEKVLEDVGKTTPQYMENMEqVFEQCQQFEE 239  human
3HAJ_A     159 hhaackeeklaisreanskadpslnpeqlkklqdkiekckqdvlktkEKYEKSLKELDQGTPQYMENMEqVFEQCQQFEE 238  human
2EFL_A     150 ckeadraqqyfekxda-------dinvtkadvekarqqaqirhqxaeDSKADYSSILQKFNHEQHEYYHtHIPNIFQKIQ 222  human
NP_593322  161 cnklnsymrqtkk-------------mtgreldkynlkirqaalavkKMDAEYRETNELLLTVTREWID-RWTEVCDAFQ 226  fission yeast
EED46620   187 aeqydr----------------------------vktgdkqsgkfglKGPKSAAQHEEELLRKVQNADS-DYASKVQAAQ 237  Aspergillus flav...
P07332     160 ----------------------------------------skdkdrdKAKDKYVRSLWKLFAHHNRYVL-GVRAAQLHHQ 198  human
NP_055639  159 eqmahavrekadi--------------eaksklslfqsrislqkasvKLKARRSECNSKATHARNDYLL-TLAAANAHQD 223  human
Feature 1             #  #  ##  #   #  #   #   #  ##  # 
2V0O_A     206 DIe----ETHLIHIKEIIGSLSNAIKEiHLQIGQVHEEFIN 242  human
Q91Z69     242 EYl----LTLEATNASVFKYYIHDLSDlIDCCDLGYHASLN 278  house mouse
2V0O_B     206 DIe----ETHLIHIKEIIGSLSNAIKEiHLQIGQVHEEFIN 242  human
3HAI_A     240 KRl----VFLKEVLLDIKRHLNLAENSsYIHVYRELEQAIR 276  human
3HAJ_A     239 KRl----RFFREVLLEVQKHLDLSNVAgYKAIYHDLEQSIR 275  human
2EFL_A     223 EXe----ERRIVRXGESXKTYAEVDRQvIPIIGKCLDGIVK 259  human
NP_593322  227 HIe----EYRLEFLKTNMWAYANIISTaCVKDDESCEKIRL 263  fission yeast
EED46620   238 AAr---qELVSTHRPQAVHNIQQLISEcDSGLTLQMQKFAT 275  Aspergillus flavus NRRL3357
P07332     199 HHhqlllPGLLRSLQDLHEEMACILKEiLQEYLEISSLVQD 239  human
NP_055639  224 RYy---qTDLVNIMKALDGNVYDHLKDyLIAFSRTELETCQ 261  human

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