Conserved Protein Domain Family
BAR_SIP3_fungi

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cd07609: BAR_SIP3_fungi 
The Bin/Amphiphysin/Rvs (BAR) domain of fungal Snf1p-interacting protein 3
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. This group is composed of mostly uncharacterized fungal proteins with similarity to Saccharomyces cerevisiae Snf1p-interacting protein 3 (SIP3). These proteins contain an N-terminal BAR domain followed by a Pleckstrin Homology (PH) domain. SIP3 interacts with SNF1 protein kinase and activates transcription when anchored to DNA. It may function in the SNF1 pathway. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153293
View PSSM: cd07609
Aligned: 26 rows
Threshold Bit Score: 204.055
Threshold Setting Gi: 213407270
Created: 14-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##   ## ##  ## ##  #           #  ##                   
EDV12495       32 ASVNFFQTRVDALEDWIEKTVDFFDQKYKvSFEDFRRAKETLLSQLLpppaLLSNGFVSNQSFTPRLIDSFNKDYYDFSM 111  Saccharomyces...
EDK41555       33 ASTNHLDIQVGNIEKWMKALVSSVKKFPR-YVTEFQGFANSFLESFLp---TFLQDGLIDQEYTIESLQSTASALGDVWI 108  Pichia guilli...
XP_001385516   86 ATINHLDTQVVNIEKWILALSSSIRKIPS-YIKEVQSFCNSFLEHLVp---SFIQDGLIDQEYTVQSLNTTLSGLKKLWA 161  Pichia stipit...
CAG88188       29 ASINHMDDQIDNIEKWIIALSSSVKKFPK-YLEELQSFSNSLLEHLVp---PFIQDGLIDQEYTVQSLTTTGDGLKRLWG 104  Debaryomyces ...
XP_001526732  109 ASVNHMDNQLNNIEQWLIALSSSIKKLPR-YLQEVESFCNSFLEHLAp---GFLQDGFIDQEYTVEALHATILGLKTIWG 184  Lodderomyces ...
CAQ43398       34 AHVNHFQTKVESLEDWIEKTVGFTESHYDvSLDDFQRTQSTFLSQLLpspiVLSNGFVDNQLYTPWLVESFNKEYAEFNT 113  Zygosaccharom...
XP_448053      32 ATVNFFHTRVDIFEEWIDKSMAFYEKKYThSYDDFKRTQNSLLSQLLpspsMLSSGLVSNQGYTPSLVSNFLFDFTEYSE 111  Candida glabr...
XP_447337      46 ATVNFFDGRVKYLSDWSSETALTLQNKYRpALSEFMKVQNGLLHQLLpdpnMVANGMLINQAFTPTLIDSFNKDFNKLAV 125  Candida glabr...
EDN62394       27 ASVNYFHTRMESLSSWMHSTVDYVENTYKpSFQDFQRIKETLFSQLLpspiLLSNGFVSNQPYTPLLVRDFTRDVSDLSN 106  Saccharomyces...
NP_986199      36 ATVNYFDLQLERTEKWIRTTSEITKGRYHnSLDEFKQVSLSLIDFILpedtYLNHGTVEEQIYTPKLVSKCRDGIRDMFH 115  Ashbya gossyp...
Feature 1                                                                                         
EDV12495      112 KLLQIVKgddss---hstaLLELMTTAIEPYRNVRKNFDFYQGKYDSMLASyqairiskts------------------- 169  Saccharomyces...
EDK41555      109 HTFESLNfets----wvqeLSSKISRQIQRYREIKVNFDAAQEKFDSYLNIyvaqaktr--------------------- 163  Pichia guilli...
XP_001385516  162 ISLSSLNvnty----tidnIRTVVSKNVAYYKELREKFDASQQKYDKYLEIyvstsktk--------------------- 216  Pichia stipit...
CAG88188      105 TSLAAMNvnsy----aidrLHSRVIRDINHFRESRTRFEMAQNKYDKYLEIylassktk--------------------- 159  Debaryomyces ...
XP_001526732  185 RSLNAFSinpq----ildeMSEFRKSRVVKYRELRRRFELCQIKYDKYLSIfvsssksk--------------------- 239  Lodderomyces ...
CAQ43398      114 TLLGILSgqdsg---ypnvLLELMTKSIEPYKSKRANFEYYQNKHDNMLNQqqavdinnas------------------- 171  Zygosaccharom...
XP_448053     112 RIIKALKgndil---nstpLSELISVAIDPYKACRKSFDYYQTKYDSMLSTfqaanirevs------------------- 169  Candida glabr...
XP_447337     126 GLLSIILgndtscskvlnlLNGLKKKAIAPYVDKKNTFDYFQQKYDSAHARysaieptkvvanstnidatsvnsspipng 205  Candida glabr...
EDN62394      107 TVMKIILgdens--qytaaLSALSSDAINPYFNKRKTFEYYQRKYDSFLTDflaatndgnt------------------- 165  Saccharomyces...
NP_986199     116 GVLEVIQgnpel---ylsiLLDVVKSVIDPYKDAWKNFEYYQSKYDGMLAKyqglqwtes-------------------- 172  Ashbya gossyp...
Feature 1                                              #  ## ##  ## ##     ##  ## ##              
EDV12495      170 ------lepssiksdALQLFEVQKNYLKASLDLISAISAVKLSLDKFILESMKV---LKSRSIFITKDSGRkidl----- 235  Saccharomyces...
EDK41555      164 -------ephmvkedAYNLYEARISYLHESLELVLALNALNRICDEVLISLCSK---VWDNRIGSLASEKVlpnf----- 228  Pichia guilli...
XP_001385516  217 -------dvamamedAKQLHVVRKEYLHASLDLIIELSALGNHLDKVLVNLSSD---LWKYKFSYITNDALdpff----- 281  Pichia stipit...
CAG88188      160 -------nptivmedVAQLFQVRRDYIHESLEVVIQLTKLGNLLDKLLVRFSTD---FWKNKKELFTNWVDtay------ 223  Debaryomyces ...
XP_001526732  240 -------davmvvedAKQLHQVRKEYIHISLDLVVELQDIGSSLDRLLVTLNYK---LWEKKWSQFANSASsdvl----- 304  Lodderomyces ...
CAQ43398      172 ------itpasiredAFQLYEVRQSYLDASLELVVAISSMKLGVDKCVMEIIGL---TQLKNTFTFQHTGKkvdl----- 237  Zygosaccharom...
XP_448053     170 ------idpettkndTIHIFTLQKSYIQASLDLIEAIYTLRLQIDKFLLDTMNN---MKSDSIYSPKDGSRpldl----- 235  Candida glabr...
XP_447337     206 tstvlevdpsflrdeHNQLFESRKEYLKSSLDLVAAMSQLKFKLDKMLVDLIDE---LISESTITVNDESLnvdgmelgr 282  Candida glabr...
EDN62394      166 ------lipqnlqneTFKLFDIKHKYIEASLDLTEAISLMKVNLDKFLIETIDI---VRKNNVITTKDTKDvid------ 230  Saccharomyces...
NP_986199     173 -------tphrirdeALLLYDYYDGYLDAALQLVLVISDVKMRYDSLIFSLATCllpVQGSLVPKPTSTYEk-------- 237  Ashbya gossyp...
Feature 1                  ## ##         
EDV12495      236 -----spciNEYLDNYAIWVENS 253  Saccharomyces cerevisiae RM11-1a
EDK41555      229 ------tesYKRMKRIQAWSAAY 245  Pichia guilliermondii ATCC 6260
XP_001385516  282 ------keqYSKIQKIQSWSDSY 298  Pichia stipitis CBS 6054
CAG88188      224 ------keeWEKISKIQNWSDCY 240  Debaryomyces hansenii
XP_001526732  305 ------rehWEKVQQVQSWCESY 321  Lodderomyces elongisporus NRRL YB-4239
CAQ43398      238 -----tpllNEKFSSYSEWVENS 255  Zygosaccharomyces rouxii
XP_448053     236 -----mpsmNEYMKDYTMWVQNA 253  Candida glabrata CBS 138
XP_447337     283 ktielspniSNYLKDYKSWVEDV 305  Candida glabrata CBS 138
EDN62394      231 -------itPELTETLKDWTDWI 246  Saccharomyces cerevisiae YJM789
NP_986199     238 --------wAAFHKMHEKWNRER 252  Ashbya gossypii ATCC 10895

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