Conserved Protein Domain Family
BAR_ArfGAP_fungi

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cd07608: BAR_ArfGAP_fungi 
The Bin/Amphiphysin/Rvs (BAR) domain of uncharacterized fungal Arf GAP proteins
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. This group is composed of uncharacterized fungal proteins containing an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, and an Arf GTPase Activating Protein (GAP) domain. These proteins may play roles in Arf-mediated functions involving membrane dynamics. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153292
View PSSM: cd07608
Aligned: 13 rows
Threshold Bit Score: 163.294
Threshold Setting Gi: 45199244
Created: 13-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##          # ##  ## ##             ## ##  ## ##  #               #  
T49496        335 ATMKALEQKTGNMRMq-------MKRLIKRAEQVYAaqte----andAFLQFMEALRDVSSTnanavq---paiehYFDK 400  Neurospora cr...
XP_002171746  218 ATMLNFERTANETRSa-------LKKVIKRSEDYAQtsgl----myvSNNEFSQVLSKAANVnppafg---pfvdhYHRE 283  Schizosacchar...
XP_502535     338 ATIQSLEKKTRSLKAl-------IKRLYKQAVVVSErq-------seLATEYTLYLDYMKDIdgiq------vaagATCE 397  Yarrowia lipo...
NP_595897     257 ATILNYERTTHDMRMv-------LKKLIKRIEHVAHsh-------glLYMSYKELMSAFERVatinppafkpfldhYYAA 322  fission yeast
NP_594153     236 SMLHELEQKSSLMKYy-------CKKIMKRIVQLSDayda----sqvAVMKLSETLSEASNStsmnmd---illdsYLTK 301  fission yeast
XP_002173487  248 SILRELGRKTECFRGd-------VKKLLKRIQELSEafefi-agalgRFMESVLTASATCPAafqp------lvetYVAP 313  Schizosacchar...
CAX44587      267 KGYSNLIDEFRMLESs-------VRRVTNSKIKVMDaid------hiVDLESTSLLKEFGFKhdfhv-----vfkaMFEP 328  Candida dubli...
EDK39575      245 KSFVGFSEEIKLLEHy-------LKRVNNSKSRIID-----------YFNQVTSFQKILPREriksef--sssldsLFDP 304  Pichia guilli...
XP_001526735  274 KIYSKLIDDFKVLESn-------VRRMSSTKFKIIEgin------qlVDLESQSLLTELKFKesfqk-----afrrLFEA 335  Lodderomyces ...
XP_001385513  256 RAVSNLHEELKSLETs-------LKRLTSTKVKLIElv-------nsTEFQFNNLIDQFGFAkdfer-----ifrsIFDP 316  Pichia stipit...
NP_986273     211 TQLANWESILFLFRSh-------LKSLYERSTKLKEllqmtskefnlLSNDFNELHCILKDQpv-----------sSVFR 272  Ashbya gossyp...
CAR65832      279 RICGEFIEQRRNLEFym----kkILICKKRIIEVMNd---------lVNLQFNSLLSQFNFKndfka-----ainsIFDP 340  Debaryomyces ...
XP_758578     575 AALVNLERRTASIKKaskavlraSQEARLRIFRLIEae-------qaVDTALQALVGMAPETi------------gRLQD 635  Ustilago mayd...
Feature 1         ##                                                                              
T49496        401 IAWEILRFERQNTQNLQKIVIDPMNKLYq-----------lDIKQAEAKKRDFEEESKDFYAYVSRylgqrhd------- 462  Neurospora cr...
XP_002171746  284 SSRLLSSFYLDRAQLVRSKLVEPLRKIYe-----------nDIKTTDSKKKDFEERSRDFYASLSRylsknk-------- 344  Schizosacchar...
XP_502535     398 QWVQIAAWLNSSNVDLQMLVLTPLKKFYe-----------nEIKMFEGHKKDFDDESREYYSWLSRylgqksp------- 459  Yarrowia lipo...
NP_595897     323 AAQSFDSFNIDRARLLRNFLIEPLRKIYd-----------tDIKNVSTKKKDFEETSRDYYTSLSRylskseke------ 385  fission yeast
NP_594153     302 AMDIHATFIQKLNYDLINLLYEPFHNIYs-----------sFIKPIDDRRLEFDEQSKSFYGSLSRylsakk-------- 362  fission yeast
XP_002173487  314 SLQHQIRLFKSTCSDLIHYVFEPLERIYv-----------nDLKLATVKRIEFEEFSKNYYTSLSRylankt-------- 374  Schizosacchar...
CAX44587      329 FEKNLNFFFENVCDHKLLNKIYANIGFTqi----------dSSAVYLELQKKFEADSKEYYSWLNKylsne--------- 389  Candida dubli...
EDK39575      305 FNHNVRFLLSRVLPATMLQKAITYVPVDsgan-----adflGSVELSHIKKQFEARSKDYYSWLNKylsne--------- 370  Pichia guilli...
XP_001526735  336 FEIDINFFFDHVCASKQLVKIENSIPALqid--------naNQTELSQMKRQFESDSKEYYSWMNKyland--------- 398  Lodderomyces ...
XP_001385513  317 FEKNLRFFLKNVCDQKLITKISQNLSYNslegsgssssnsnHHNELLQRKKVFESNSKEYYSWLNKylsne--------- 387  Pichia stipit...
NP_986273     273 HLLLSSSSVCVSQARLMMKKATASQEDLasaiqq--ylntiDLKAVSSSKKQYHDQAKDFYSYVGKnls----------- 339  Ashbya gossyp...
CAR65832      341 FEKNLLFFTRDVCDSKILDKISSTLSTNltgn------easSSNELLYNKKHFENTSKDYYSWLNKylsne--------- 405  Debaryomyces ...
XP_758578     636 QLLRQARIATMQHQREQASVIESCLERPlaq-------iveLCRLAQDGFKLFENESKTYYSQTQKwlanrssnadpsnt 708  Ustilago mayd...
Feature 1                                            #  ## #            #  ## ##             ##  #
T49496        463 ------svkakqsDSKYQTKRKNFELKRFDYSSFMQDLSGGRKeq-------eILSHLTKYADA-----------QAKAF 518  Neurospora cr...
XP_002171746  345 -------eadkvkDSKFSAKKREFELTRFDYYSYMQDINGGRKgq-------eILSVLTNFATQ-----------DYALI 399  Schizosacchar...
XP_502535     460 -------pkasksDSKYQDKRKAFELKRFDYFTYLTDLHGGRKmq------alTLSISQNEEKQ-----------LARFL 515  Yarrowia lipo...
NP_595897     386 ------tssdktkESKFAAKKRDFELSRFDYYSYMQDINGGRKgq-------eVLSVLTSFAAN-----------DYNLI 441  fission yeast
NP_594153     363 --------dkkggDSKFFQKEKTFALQRYDYYCFMQDLHDGSIin-------dINGIFLQYFHR-----------QYDHI 416  fission yeast
XP_002173487  375 -------tdmakdESKYLVKKKDFELRRFDYYCYIQDLHDGPKtq-------dILAIFTSYFYQ-----------QHEKW 429  Schizosacchar...
CAX44587      390 ---------kerpESKLLAKRKVFELSKFDYLNSLTKVTNNQYvn-------eVLENFFKFLNL-----------KYDQR 442  Candida dubli...
EDK39575      371 ---------kerpESKLLAKRKTFELSKFDYLNQLNMAFNNQY----------LNQILENVFPV-----------HSLEL 420  Pichia guilli...
XP_001526735  399 ---------kerpDSKLLAKRKVFELSKFDYLNQLSKTTNNQYvn-------eLCENLFQFINLgf--------sKSNSR 454  Lodderomyces ...
XP_001385513  388 ---------kdrpESKLLTKRKTFELSKFDYLNHLNTITNNQYsn-------qLLESLFKFINM-----------TFDER 440  Pichia stipit...
NP_986273     340 ----------qksDSKLLPRRIQFELQRFDYFHSLLQYVVGCNard----favSLARFQSSIDPnnkntnmhlvkKYRSH 405  Ashbya gossyp...
CAR65832      406 ---------kerpESKLLSKRKIFELSKFHYLNHFNQLLNNQYfn-------qLLENLFKFINLh----------YHGKY 459  Debaryomyces ...
XP_758578     709 paigndahrqdraDQKQKLRELRFEQARLDLFAMLQRLHGGRAeahlarsilqLTQWLVDFPNKp----------HWPSH 778  Ustilago mayd...
Feature 1         # ##      ## ##   
T49496        519 LTTAKk----VEGLLPQL 532  Neurospora crassa
XP_002171746  400 NQLLSd----IKNLRPNL 413  Schizosaccharomyces japonicus yFS275
XP_502535     516 ALSAG-----IQASKPKI 528  Yarrowia lipolytica CLIB122
NP_595897     442 HSSLTd----IDALRPSI 455  fission yeast
NP_594153     417 ALFSNl----MNSVLPNL 430  fission yeast
XP_002173487  430 VHSSEs----IDSLHAQL 443  Schizosaccharomyces japonicus yFS275
CAX44587      443 YPRLL-----DYHSFKDK 455  Candida dubliniensis CD36
EDK39575      421 RSRCY-----YLHRHKSI 433  Pichia guilliermondii ATCC 6260
XP_001526735  455 VLDVKky--lDKSLKHEL 470  Lodderomyces elongisporus NRRL YB-4239
XP_001385513  441 NPKLLdfekyNDAKMSQN 458  Pichia stipitis CBS 6054
NP_986273     406 FLPFNk---iKSQQRIRL 420  Ashbya gossypii ATCC 10895
CAR65832      460 LHTEIf----LDIKLSRN 473  Debaryomyces hansenii
XP_758578     779 TQTSS-----LSALDASL 791  Ustilago maydis 521

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