Conserved Protein Domain Family
BAR_ACAPs

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cd07603: BAR_ACAPs 
The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing proteins
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. This subfamily is composed of ACAPs (ArfGAP with Coiled-coil, ANK repeat and PH domain containing proteins), which are Arf GTPase activating proteins (GAPs) containing an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, and C-terminal ankyrin (ANK) repeats. Vertebrates contain at least three members, ACAP1, ACAP2, and ACAP3. ACAP1 and ACAP2 are Arf6-specific GAPs, involved in the regulation of endocytosis, phagocytosis, cell adhesion and migration, by mediating Arf6 signaling. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153287
View PSSM: cd07603
Aligned: 15 rows
Threshold Bit Score: 242.979
Threshold Setting Gi: 3183210
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 #  ##   # ##  ## ##         ## ##  ## ##  #             #  ##          
AAH51194      16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQcqgdtvisecLQRFADSLQEVVNYHMNL 95  human
XP_002218526  18 RVSLEQVENDIHDLETKLEKVIKLCNGMMEAGKAYNTANGAFIRGVKELSVYfrgdqqvndaLCRFADGLTEMLNYHTIL 97  Florida lancelet
NP_001006548  18 RAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCLANKQFMNGIRDLAQYsckdalvetnLTKFSDTLQEMINYHNIL 97  chicken
XP_001186513  18 RSALEDSEADISDLEHKLEKLVKLCNIMVEAGKAYNNAFGSFITGTNEIMKYfrgddlvqnyLLKFMGAMNETRNYQAIL 97  purple urchin
XP_001629872  23 RLQIERGEHDVTTLEAGLEKVIKQCNAMVDSGKAFISSTSLLLSSIHVLTKYfnedelvqgpLKKFSQTFEELNNFFKTL 102 starlet sea ane...
NP_001072017  18 RDLVHQSEVDVVDLESQIDRMVKHCSVMVDSGKVYNNACKGFIGSVNDVGYAstddafvqgtLKRFTSTMSELSSFHTML 97  Ciona intestinalis
NP_001091664  18 RQSLDKCESDMSELESRVEKVMKLCGQMVDAGQNYTSCNQLFLCALSEFTAYhksdgvilncLRQFNQGLQEMIQFQTML 97  zebrafish
XP_001947780  17 RTQLDRHESNIDLLEHRLEKVVKVYSLMIDSGKTYVSQQSLFANSLWEMGLCfrddtsstknLNKIIHALQEMNKFLTTF 96  pea aphid
AAL39259      18 RQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFAMSLWDLQQHfldnknahnaLGKLIHCFQEMNKFHTIL 97  fruit fly
XP_002113723  18 RTSLQNVEKDVNSFDTEIDKLAKLYNGLSDASKTCSNANRAFVIGLNALKDHfvdeslvtnaISNFTQIFTDLENFYKRF 97  Trichoplax adha...
Feature 1                                                                                        
AAH51194      96 FDQAQRSVRQQLQSFVKeDVRKFKETKKQFDKVREDLELSLVRNAQaprhr-pheveEATGALTLTRKCFRHLALDYVLQ 174 human
XP_002218526  98 FDQAKRAISKNLDHFVKnDLKKVKDTKKHFEKISDDMDAALSRQAQanrnk-pqeleETNNILTAMRSCFGHVTLDYVFQ 176 Florida lancelet
NP_001006548  98 FDQTQRSIKAQLQTFVKeDIKKFKDAKKQFEKVSEEKENALVKNAQvqrnk-qheveEATNILTATRKCFRHIALDYVLQ 176 chicken
XP_001186513  98 EDQAVRGVSKSLSAFIKgDLKKVKEAKRLFYRISDDYDNALHKNAQtvrtk-pleseETLNVLTATRSAFGHTALDYVFQ 176 purple urchin
XP_001629872 103 LDQTQMSISTTLQQFVKnDVKRVKETKKLFDKISDELDNALNKHAQlpktckqheleEDRNILTAMQSCFDHISLDYAFQ 182 starlet sea ane...
NP_001072017  98 FDQAQRSVRTQLNNFLReEVKPTKDLKKTFDKVSDDYLSSLNKHAAanklk-pneveDTNSVLTSSRNCFRSVAMDYVYQ 176 Ciona intestinalis
NP_001091664  98 FDQTQRAISQQLTNLLSqFVPQIRETRREFVRIGDDLDSAVVKNAQvsrhk-pvdaeRATHLLLATRKCYQHFALDYCLQ 176 zebrafish
XP_001947780  97 LDQASRTVLNNLTVFVKeDIKASKESKHVFEKATYELDAALLRNSQvlksr-pheadELLSQVASARSSFRHAALDHVHC 175 pea aphid
AAL39259      98 LDQASRTVLKNLSVFVKdDINQVKDYKGHFLKVSEGYDNALIKNAQasknr-pqemqEAANILSASKSCFQHTALDYVNY 176 fruit fly
XP_002113723  98 IDECQALSSTYMQNYIKeDIKRVRDYKKSFDKISDEFDTAINRNASaqkik-tieveEAEQNFKSTRSWFSHIAFEYCYN 176 Trichoplax adha...
Feature 1         #  ## #     #  ## ##  ##  ## ##  ## ##   
AAH51194     175 INVLQAKKkf-eiLDSMLSFMHAQSSFFQQGYSLLHQLDPYM 215 human
XP_002218526 177 INVVQSKKrf-kvMDTMLSFMYAVNTFYHQGYDLTNDLEPYM 217 Florida lancelet
NP_001006548 177 INVLQSKRrs-eiLKSMLSFMYAHLTFFHQGYDLFSELGPYM 217 chicken
XP_001186513 177 INIVQSKErh-evLNTLLSFMHAQFTFFHQGYDLMKDLNPTF 217 purple urchin
XP_001629872 183 INLLQSRKri-evLDALSKFMHSHFTYYHQGYDLMNDLERYM 223 starlet sea anemone
NP_001072017 177 INMLHKKKkf-qsVDKILSYMHALFTFFHQGYDLLKDLEPYM 217 Ciona intestinalis
NP_001091664 177 LNNFKVQQkl-diLNSVFSYFHAQYTFFHQGFDLLRDLEPTM 217 zebrafish
XP_001947780 176 ITMLLTRKkp-eiFSTLLSYIQAWGTYFHQGFTLTEDLQDFI 216 pea aphid
AAL39259     177 ITLAQARKvp-siLSTLLDYYQACVTYYHQGFDLCNDFDEFF 217 fruit fly
XP_002113723 177 LMSLFKSYrklvdESSLLLQQFSPFTDDLTTQIEREKENFIQ 218 Trichoplax adhaerens

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