2ELB


Conserved Protein Domain Family
BAR_APPL

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cd07601: BAR_APPL 
Click on image for an interactive view with Cn3D
The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing proteins
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing (APPL) proteins are effectors of the small GTPase Rab5 that function in endosome-mediated signaling. They contain BAR, pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains. They form homo- and hetero-oligomers that are mediated by their BAR domains, and are localized to cytoplasmic membranes. Vertebrates contain two APPL proteins, APPL1 and APPL2. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153285
View PSSM: cd07601
Aligned: 3 rows
Threshold Bit Score: 363.46
Threshold Setting Gi: 149241632
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interfaceputative
Conserved site includes 36 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              #  ##   #  #  ##  #         ## ##  ## ##  #                 #          
2ELB_A     40 RSLLGVFEEDATAISNYXNQLYQAXHRIYDAQNELSAATHLTSKLLKEYEKQRFPLGGDDevxssTLQQFSKVIDELSSC 119 human
AAH33731   20 RSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQLLAYEKQNFALGKGDeevisTLHYFSKVVDELNLL 99  human
XP_784602  20 RSLLNLFETDALQLSSYMKGLLDVCKNVVDCQNTLKSATQALSTKLGEFESWKFELGRDDsilvsTLKQFAGNVDQVSTM 99  purple urchin
Feature 1                                                                                     
2ELB_A    120 HAVLSTQLADAXXFPITQFKERDLKEILTLKEVFQIASNDHDAAINRYSRLSKKRen-dKVKYEVTEDVYTSRKKQHQTX 198 human
AAH33731  100 HTELAKQLADTMVLPIIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKKKen-eKVKTEVGKEVAAARRKQHLSS 178 human
XP_784602 100 HSTLSSSLEDTVLHPLSRFMNSDIAEIMSMRELYKANQHDHEGVLSKYSKVSKKRehetKQCIEMNDELYACRKKLQQTA 179 purple urchin
Feature 1            #  ## #    ## ##  ## ##  ## ##   #  #            
2ELB_A    199 XHYFCALNTLQYKKKIalLEPLLGYXQAQISFFKXGSENLNEQLEEFLANIGTSVQ 254 human
AAH33731  179 LQYYCALNALQYRKQMamMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQ 234 human
XP_784602 180 MNYYTALNLLQYKRTTglLEPMIGYLQAHMAFVKMGPQMFTRQTEEYLSDINTSVQ 235 purple urchin

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