Conserved Protein Domain Family
BAR_Gvp36

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cd07600: BAR_Gvp36 
The Bin/Amphiphysin/Rvs (BAR) domain of Saccharomyces cerevisiae Golgi vesicle protein of 36 kDa and similar proteins
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. Proteomic analysis shows that Golgi vesicle protein of 36 kDa (Gvp36) may be involved in vesicular trafficking and nutritional adaptation. A Saccharomyces cerevisiae strain deficient in Gvp36 shows defects in growth, in actin cytoskeleton polarization, in endocytosis, in vacuolar biogenesis, and in the cell cycle. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153284
View PSSM: cd07600
Aligned: 17 rows
Threshold Bit Score: 233.015
Threshold Setting Gi: 151942920
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                             #  ##        # ##  ## ##                   
NP_012223     57 TELEDKVDTIKLIYNHFLGVTAIYENGSYDYPKYINESVNEFSRs----vASKLTELTHATSASEaqnilv--------- 123 baker's yeast
NP_983981     81 VELEQRVDRTKLIYDNFLKVSQIYESESYDYPQHISDSVNDFSKt----vTGKVQELTKATTTEEaqsili--------- 147 Ashbya gossypii...
EDK41281      87 LELAERCNNIEKLYKNVLKVTSNYENESYDYPTNLQESFTDFGKn----iSSRVSNLSKATTPAEaqaalin-------- 154 Pichia guillier...
EED20666      44 LELEKRVDALKQVHQKLLSVTSQYSNEAYDYPPNIRESFNDLGRt----iSEKVNLLSHASSPAEaqaalta-------- 111 Talaromyces sti...
XP_001643644  57 LDLELKIDTYKSVYEHFLKITSIYERESYDYPKEFSESVNEFTDs----iGNKMYEFSNGVSTEGss------------- 119 Vanderwaltozyma...
CAX45396      78 QLESNCDLLLKLYTDLIQTTNETYGKVSYDYPPGNYAINKIKDAnvsgliGQKFNQLKNVSSPQElekvllgqdvdvesk 157 Candida dublini...
XP_454149     68 VQLEHRVETIKLIYENFLKVTKIYENESYDYPSNVKESVDEFSKl----vGGKLHDLSKVTNREQaqnvll--------- 134 Kluyveromyces l...
NP_985856     78 GFLERKCDAIEQVCKKILVVSKTFEVEGYDYPPNPTESISDWWNt----sTKETRFLKFGKGGTDkqkedkq-------- 145 Ashbya gossypii...
XP_449146     58 VVLEKKCDSIEKVLKRILIVTKTYEIEGYDYPPNISESLSSWWQtk---eWFNISELTKNVIPKHgnvekagteas---- 130 Candida glabrat...
XP_454154     68 KFLEQKSDALEKICKRLLLVTKTFEVEGYDYPPNLTESFNDWWS------GNKDSIFSFSKKKAEvspevke-------- 133 Kluyveromyces l...
Feature 1                      ## ##  ## ##  #                                                   
NP_012223    124 --------apgpikEPKTLNYALSKVALNSSEClnkmfp---------------------------------------te 156 baker's yeast
NP_983981    148 --------spgparNPKTLNYALSKVALTSSEYlsksg----------------------------------------sd 179 Ashbya gossypii...
EDK41281     155 -------pttgefkPPKTLYHALARATDASVLTnkspe----------------------------------------nq 187 Pichia guillier...
EED20666     112 --------ppsakpQPKTFSHAIARASLAGSQLiaqtt----------------------------------------pa 143 Talaromyces sti...
XP_001643644 120 ------------gkTPRTLNYAVSKVSMGASEQfqklhd---------------------------------------td 148 Vanderwaltozyma...
CAX45396     158 desgvvsiqptspqLPKTLFGHLSEICSKHSDElkss------------------------------------------- 194 Candida dublini...
XP_454149    135 --------sspqmkEPKTLNYALSKVALTSSEHved-------------------------------------------- 162 Kluyveromyces l...
NP_985856    146 -------kqaagssDPPSFAHALHRAAKGSQGIiqelkeqaeeeq--------------------------eqeveided 192 Ashbya gossypii...
XP_449146    131 ---ktltdkevsheGPPSFASAIARAGKDSQLIfesietkde---------------------------------deked 174 Candida glabrat...
XP_454154    134 --------taenglLPRSFAQALSKAATDSALIlkqlkaeetrtnqeesqegadqkpaeetkaepeleaeadedededed 205 Kluyveromyces l...
Feature 1                  #  ##                                                                 
NP_012223    157 eqpLASALLQFSDVQAKIAQARIQQDTLIQTKFNKNLRERLsfEIGKADKCRKDVHSMRLRYDVARTNlannkkp----- 231 baker's yeast
NP_983981    180 dvvTADILLKYSDVQAKIAQARLQQDTLIQTRFNRRLREKLntQFAEAMQSRKQVDQKRLQYDIARANftaarp------ 253 Ashbya gossypii...
EDK41281     188 ddhLVKALDLYSGGINKIANARLGQDQLITSKFNKPLSSTLrqLISQSNNIQKKVEQKRIDYDMARANlssstna----- 262 Pichia guillier...
EED20666     144 edpLSTALEKYALALEKVGEARLAQDAQIQSRFLAGWNTTLntNLTFATKARRNVENARLNLDSIKARkkaaaggd---- 219 Talaromyces sti...
XP_001643644 149 dkrIANLLTNVGNAEASIAEARLLQDHSIQAKFNFQLREEIaqSIERASKYRKEVYHKRLKYDIAREKyskhe------- 221 Vanderwaltozyma...
CAX45396     195 ehpLSFALLQVSSTYQEIAVARLDQDKKIMSELNAELIKTLneSFIKVNELRKKVYSTRGEFDLLRSKyeks-------- 266 Candida dublini...
XP_454149    163 -esLANFLAKYSDSQTKIAQLRLQQDTMIQTKFNKAIKEKLeqDIETSTKARKLVEQKRLQYDVVRSNrlkntkp----- 236 Kluyveromyces l...
NP_985856    193 vesLIKMFGTWADAQYNMDIAKREMDQFMVKEFNEKLKHLLevEFKKGHTLRRKVEESRLTFDTLKYEqherdaalakkq 272 Ashbya gossypii...
XP_449146    175 ideLVKIFKIWSDCFYEISDSKTEMDQMMIKEFNVKLEDYLqkNFQKIHTLRAKVEESRLNFDTMRYEvaqtskqtdske 254 Candida glabrat...
XP_454154    206 vdnLIKAFESWTKCQLSIDQSKAEMDSLMVKEFNAKLSKLIetDFKKGHELRAKVQDARLNFDTLRHEiklklqekevva 285 Kluyveromyces l...
Feature 1                                                                  #  ## #               
NP_012223    232 ------------------------------ekeaslRVQMETLEDQFAQVTEDATVCLQEVISHAn-------------- 267 baker's yeast
NP_983981    254 ------------------------------ekqaslRVQMETLEDQFAQSTEDAVALMQAVIDDTe-------------- 289 Ashbya gossypii...
EDK41281     263 ------------------------------tkepqlRVIMENAEDEFANTVEDAINIMQNVLENAk-------------- 298 Pichia guillier...
EED20666     220 ----------------------------ldnlsedaRIEIEQAEDEFVGQTEEAVAVMKNVLDTPe-------------- 257 Talaromyces sti...
XP_001643644 222 -------------------------------kngtvKVELEILEDEFNHATKDAIMVMQEIISNNr-------------- 256 Vanderwaltozyma...
CAX45396     267 ---------------------------------dpeNEDLIAKEDGFVSATEVAVLEMKKLLKPSk-------------- 299 Candida dublini...
XP_454149    237 ------------------------------ekqaalQVEESTHEEEFAKATDDAIIAMSKVVELAd-------------- 272 Kluyveromyces l...
NP_985856    273 deakqae-----------gatpstgvtqsstadlafYAQLEDAEDEFVSNTAEAVEFMTSIADATk-------------- 327 Ashbya gossypii...
XP_449146    255 lgnedet-----------kpssmdanktnteekeaaNDKVETKEKTETNATIADETKETKDTKDSedlkedsktstdgql 323 Candida glabrat...
XP_454154    286 sseeaekkvatetpetpekktneepvdmakteedpdSKLFERLEDQFVSATSETVEFLGELTDSSe-------------- 351 Kluyveromyces l...
Feature 1         #  ## ##    ##  ## ##  ## ##   
NP_012223    268 fSEDLKELAKA--QAEYFETSAGLMKEFLSNS 297 baker's yeast
NP_983981    290 fLKEFQELVTA--QLGFHKAAAELLSGFATVF 319 Ashbya gossypii ATCC 10895
EDK41281     299 pLEEFHELIKA--QLAYHKVAAELLGAMVSDF 328 Pichia guilliermondii ATCC 6260
EED20666     258 pLRNLADLIAA--QLEYHKRAYEILSELAPVV 287 Talaromyces stipitatus ATCC 10500
XP_001643644 257 fEQNLKDFAAA--KLAYHEKSVDALRNLLDNA 286 Vanderwaltozyma polyspora DSM 70294
CAX45396     300 nIDLLKVLVAA--QKDYFEVGAKKLKELLDNL 329 Candida dubliniensis CD36
XP_454149    273 fSANLHELVAA--QLAYHKSSAEILEELVNEV 302 Kluyveromyces lactis NRRL Y-1140
NP_985856    328 lISLVKLFQNF--QLVYHRKCVQELEVSLNSL 357 Ashbya gossypii ATCC 10895
XP_449146    324 lEQLEDEFVSNttEAVEVMTEVSENSELLSLI 355 Candida glabrata CBS 138
XP_454154    352 iISLVKLFHNF--QLIHYKQCVKSLEEDLEVL 381 Kluyveromyces lactis NRRL Y-1140

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