Conserved Protein Domain Family
BAR_SNX8

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cd07597: BAR_SNX8 
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. SNX8 and the yeast counterpart Mvp1p are involved in sorting and delivery of late-Golgi proteins, such as carboxypeptidase Y, to vacuoles. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153281
View PSSM: cd07597
Aligned: 27 rows
Threshold Bit Score: 185.972
Threshold Setting Gi: 158300655
Created: 12-May-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
dimer interfacedimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                              #  ##   # ##  #  ##                ## ##  #  ##  #        
NP_037453    195 DEFLNCKLaTRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTtplpswa 274 human
XP_414774    142 DEFLTCRLaTQAKDFLPADIQAQFAASRELIRNIYNSFYKLRDRAERIASRAIDNASDLLIFGKELSALGSDTtplpswa 221 chicken
CAF94131     101 DEFMTNRIaTQAKEYLPADIQAQFLTSREVIKNIHNSFNRLRDRAETMAERSKENAADLLMFGRELRYGRDNSqhsplvt 180 spotted green p...
XP_001338821 147 DEFLISQIaLHGKVYLPEDIQSQAAANREVIASIHSSFYKLRDVAERMAQRSRENSTDLLMFGKDLSELGSDTsdlpeda 226 zebrafish
XP_002127832 249 DEFERSSLtDQTKDLVPPETQTEFAASKEHIRQITTHVVKLRDMATRISERSKGNAADILGFGKELIAIGNDGttasawa 328 Ciona intestinalis
XP_396294    255 DEFATSELsSRAKELVPPETLTEFANSRDQIRVILLGISRLKNIADCLAIRSHSYAVDMAELGTQLSNLASEPhgtttwa 334 honey bee
XP_002202038 257 DEFVTSPLaVQAKDLVPMDTQVQFSNSRDFIRILFNSISHIKGVSDRMVARSTGLAADMLIFGKELSVMANDPpalssws 336 Florida lancelet
XP_001623595 309 DEFATSPLsPRIKELVPMDVQASFNASKKQINALHNSVEKMKDVADHLTARTLGFSSDMLYFAKELSALSNDSipttvwa 388 starlet sea ane...
XP_968401    257 DEFMTSDL-AATAKNLLPADHGEIASSREQIRSLVQVIGKLKLLAENAVERQNSYARDSEDFAAQLKILSASSigqvf-- 333 red flour beetle
XP_001657471 130 EKQPDEFSrLREDVELPWEDQEKLLASRDRLRKILYSLHRLRKIFDEQAFRAEQQARDMAEVDLILQGLEVRD------- 202 yellow fever mo...
Feature 1                                                             #                          
NP_037453    275 ---------------------------------alnsstwGSLKQALKGLSVEFALLADKAAQQGKQEENDVVEKLNLFL 321 human
XP_414774    222 ---------------------------------alnnstwGTLKQALKGLSVEFALLADKAVQQGKQEENDVVEKLNLFL 268 chicken
CAF94131     181 vpcpelhpfakflflpplprsvlgsdgsslpswassqsswGALRQSLKSLSVEFTVLSDKAAQQGRREEDDVVEKLSLFL 260 spotted green p...
XP_001338821 227 ----------------------------------ivskawKTQRKSLVELSGEFGLLADKAAHQGTREEDEVVEKLNLLL 272 zebrafish
XP_002127832 329 ---------------------------------tggndviATLKRAFRSLSHEFSLISEKHSLQGIREEEGVLDQLSMLV 375 Ciona intestinalis
XP_396294    335 ---------------------------------tggstiwQEMKKGFHIISKEFNLLSTRALQQAVREETMVCERLNLLL 381 honey bee
XP_002202038 337 ---------------------------------cgsidtwSHLQNGFKSLSVEFGVLADKSQKQAHMEDDCLVEQLQYFL 383 Florida lancelet
XP_001623595 389 ---------------------------------cgnndswGHLKHGFNGLTGHFSKLSDKAAEWFRREDVGCGEVLALFL 435 starlet sea ane...
XP_968401    334 ------------------------------------gsqwGSMQKGFTAISRELYSLSNKSQQNANVEQITVCERLALLL 377 red flour beetle
XP_001657471 203 ----------------------------------------VFGERTFDDVSQSAQAAARQSERYVQLQRNVVNERIHVLM 242 yellow fever mo...
Feature 1                                                                                        
NP_037453    322 DLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMSAtaq---------nrePESVEQ---LESRIVEQENAIQTMELR 389 human
XP_414774    269 DLLQSYKDLCERHEKGVLHKHQRALHKYSMMKKQMMSAtvq---------nkePESVEQ---LESRIVEQENAILTMELR 336 chicken
CAF94131     261 DLLQSYRDLCERHEKGVLHEHQRALHKYGVMKRQMMSAtvq---------pkeQASVEQ---LESRIVQQENAIQTMELR 328 spotted green p...
XP_001338821 273 EQLQSYKDLCDRHDSGVLLEHQRAFEKRSGPVGTHLKY---------------QNSIEQ---PESRLSQQENTIITMEMR 334 zebrafish
XP_002127832 376 DILQAYHNLCDRHERGVLRDHHSALKRYGMMKTKRMAAtvt---------nmeQGGVDR---IESKILAQEHEIANRENR 443 Ciona intestinalis
XP_396294    382 DVLVAHRILCERHERGVSADHQRALSTMLSLKKRQMQGvi------------rGTDSDTveyLENKMVAQESVIANVELR 449 honey bee
XP_002202038 384 DLLTSYKDLCDRHEKGVLSDHQRALQKMGQMKKRKMSAtiqg--------keqTALVEQ---LEARIIEQESEINNMENR 452 Florida lancelet
XP_001623595 436 ELTTSYKELCDRHEKGVLKDHQNSLHKMQQIKKRQISAqak----------gqENMVDA---LESKIIEQEVDISNMENR 502 starlet sea ane...
XP_968401    378 DVLISHKDLCERLEKGLAHDHQQALSKMLSLKKRKIQGvir---------gtdTESVEQ---LEAKMLTQENIISNIELR 445 red flour beetle
XP_001657471 243 DLLAAHNDLCQRVEKGIFSEHQKALSKTVGFSRSRLRNsvrggnatsengatvTASQST---APASDTPPATSDPHLNRK 319 yellow fever mo...
Feature 1                   #  ## #    #  ## ###    ##  ## ##   # ##   
NP_037453    390 NYFSLYCLHQETQLIHVYlplTSHILRAFVNS---QIQGHKEMSKVWNDLRPKL 440 human
XP_414774    337 NYFSLYCLHQETQLIHIYlplTSHILGAFVNS---QIQGHKEMSKVWNELKPKL 387 chicken
CAF94131     329 NYFSLFCLHQETQLIFIYlpiTSHILGAFVNS---QVQGHTEMGQVWNELQPKL 379 spotted green pufferfish
XP_001338821 335 SYFSLLCLHQETQLVFTNlplVTSILGTFVNS---QIQGHKEMGDVWGDLHPKL 385 zebrafish
XP_002127832 444 NFFALHCIHLETQLVYANmqiLSEVVGTLVAT---QIKGHKEMMKLWEDVAPRV 494 Ciona intestinalis
XP_396294    450 NCFSLHCLHMETQLVHAHleiLATVLQSLVNV---QIRGHSELAEVWKLIEPTI 500 honey bee
XP_002202038 453 NYFSLHCVHMETQLIHANmelLVKIMEGLLST---QVRGHQELAQMWENIAPKI 503 Florida lancelet
XP_001623595 503 NFFSLHCLQMETQLVHAN---LKMIAVALKKMvysNALGNKEVAQVWAEIQPTM 553 starlet sea anemone
XP_968401    446 SDFSLYCVHMETQLVYAYletLSSILNSLVSL---RIRSHSELADIWKQVQPTV 496 red flour beetle
XP_001657471 320 CAFALQCVRSETALAEQYlqsLPAILLSYATE---ESQYHSKMSKIWHQLVANE 370 yellow fever mosquito

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