Conserved Protein Domain Family
BAR_MUG137_fungi

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cd07593: BAR_MUG137_fungi 
The Bin/Amphiphysin/Rvs (BAR) domain of Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein and similar proteins
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions including organelle biogenesis, membrane trafficking or remodeling, and cell division and migration. This subfamily is composed predominantly of uncharacterized fungal proteins with similarity to Schizosaccharomyces pombe Meiotically Up-regulated Gene 137 protein (MUG137), which may play a role in meiosis and sporulation in fission yeast. MUG137 contains an N-terminal BAR domain and a C-terminal SH3 domain, similar to endophilins. Endophilins play roles in synaptic vesicle formation, virus budding, mitochondrial morphology maintenance, receptor-mediated endocytosis inhibition, and endosomal sorting. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.
Statistics
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PSSM-Id: 153277
View PSSM: cd07593
Aligned: 9 rows
Threshold Bit Score: 264.597
Threshold Setting Gi: 71011545
Created: 12-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      #  ##   # ##  ## ##                                   ## ##  ## ##
O94478        17 QRAHLPDSFLELEQEIAIREEGLSKLFQATTIWIDsilkkv------------------dgedkeKCLACENLGKVMINH 78  fission yeast
XP_001834117  19 DKSTIAEEFQELEKDIELRKDGANKLHIAAEAYHHalskktln---------------ealgdsdKLLPIDALGIVMLVH 83  Coprinopsis cin...
NP_001141250  22 ARTAHSDEFKNLETEMALRQDGMERMQRSMSGYVKwlsqrne-----------------lldnkeRGTPMAALGRTMATH 84  maize
XP_001879801  29 EKTTVAEEFRELQRDIVLRKDGMHRLTVASEAYHHylskkkan---------------ealgeaeKLLPVDTLGIIMILH 93  Laccaria bicolo...
XP_570188     24 EKTQLSSDFLEFEKEIEIRRIGIERLHATSLPFYEqlakvkstad----------pypppgsgkdKISYTEALGLVMIDY 93  Cryptococcus ne...
XP_002174178  14 EQTQLPEEFLKLEEEIYLRHEGLSRLYQAGNCWAEalnrkv------------------dgdnknKCLPIENLGQVMTNH 75  Schizosaccharom...
Q9UUD0        21 QKTTLSDDFCSLKGETDAWLVGMDKIHRSCTRWVRnmdkrkg-----------------lldekdKQLPVTHVGSSFVEL 83  fission yeast
XP_758469    164 LSSSTPSEEDDISFQVEQRKKGIESLYTSTEAYWSylgkkkpipfdasslsvsensatngaksesKVLPVEALGLAMGCY 243 Ustilago maydis...
Q8X0D6        22 QKTTMSEDFKQLEMEMALRFEGMDRLQKSMNLYVKwlgrrcd-----------------syedkdKSIPTTYLGKTMIGH 84  Neurospora crassa
Feature 1          #             #  ##                                                           
O94478        79 SKELPQdsSYGITLSQLGKANLKIGEHQTSLAYKARVCYLDFLKRYLVQAKDFHSARKKLESRRQAYESLLQKSFKekke 158 fission yeast
XP_001834117  84 GEQFPEdsDFGTSLVKFGRAHCKAATLQEAYALTFKDTFITAIERFKEEVKEYESLRKKLESRKSALDSANTRYEKsrns 163 Coprinopsis cin...
NP_001141250  85 GEDFEQesEFGNCLLSLGRANERIGGIQDSYVDCANATWLDNLERSLAMMREYQNARKKLENRRLAYDASTNKLQKarrd 164 maize
XP_001879801  94 GEDFGEesPYGASLVKLGRAHCKVATLQEAFALTFKDTFLASIERFKEEIKEYEVLRKKLDSRRLSYDAAVSKLEKvskh 173 Laccaria bicolo...
XP_570188     94 GDEIGD--DYGDALSKYGRARCRLASAQEEFASRLGDSYIAGMESGLAAVNEYKSLRKKLDSRRLALDAAISKSQNskkd 171 Cryptococcus ne...
XP_002174178  76 GGELPQdsEYAAALFQFGQALQKIGQHQNFFANRLSTCYLDVIERYLVQMKDFHTARKKLENRRTTYDSLLHKSMKakke 155 Schizosaccharom...
Q9UUD0        84 GQALSHssSNSHTYIMYGKSMVEIGHLQEEFMDYLNNSFLANLENSLAEFKALDVKEKKMENRRLVFDALSTKIQKakke 163 fission yeast
XP_758469    244 ATAFPSdsTYGSCLGLLGDAHIQLANLQSTFTKDTSHIFLARIARSKAILDSFTAALKKLDLVTARLESAQTKVQKskke 323 Ustilago maydis...
Q8X0D6        85 GEDFASdsEFGSCLISMGRANERIGQFQETFVGEATTTWLESLERSLAMMKEYQAARKKLESRRLAYDATATKIQKarrd 164 Neurospora crassa
Feature 1                                        #  ## #   #  ## ##  ##  ## ##  ## ##          
O94478       159 ------dsrlEEDIRLALYKFEESTEQVKNRMIALKDVEADQYQQLTELIVYELNFFKESTGILNTIFNSQNSLTPQK 230 fission yeast
XP_001834117 164 kkd-kdrqeaEEELDRAQQRYDETAEDMRAHMHAIQELEITQQRELTHFLDIEINYVQQYLDVLKEVRDDWPDRNAGQ 240 Coprinopsis ciner...
NP_001141250 165 ------dfriEEEVRMNKAKFEETSEDVLRRMQDIKESEVDNITSLTQFLDAELDYHERCAEELRRVRQNWAGASSSP 236 maize
XP_001879801 174 nrkekekreaEDEMDRAKQRYEETAEDLRAHMHAIQENESSQLKDLGSFLDLEINFVQQYFDVLREVKSEWPEKSSAS 251 Laccaria bicolor ...
XP_570188    172 ------tgvlEEEVSIARIRFEEIEEETHSRMVNIQEAEDEQYALLTDLLEAEVDYHNKCKEILEDLRNSWGTHSSRK 243 Cryptococcus neof...
XP_002174178 156 ------dprlEEDLRFASYKFQESSEDVHKRMKALKSADSSQYDDLLLLLQHQIDYFQESLKVLQQLHQLVTQSNKEE 227 Schizosaccharomyc...
Q9UUD0       164 ------esklEEDLRNARAKYEESLEEFEDRMVQLKELEPDRVENVVRLLQMQIRFHQKSLDLLKGLEMNGFSKKRDN 235 fission yeast
XP_758469    324 ------krelEEELRQAKAAYDEAVMDVEARGGAVQDSEAEDWLCLTDYMQAQLDYLGQAQAVMEHVKAAWSAPPTGS 395 Ustilago maydis 521
Q8X0D6       165 ------dfriEEELRGAKAKYEEASEDVGRRMQDIRDSEVDSVRDLTQFLDAELEYHERCADELRRVRQSWAGGAISS 236 Neurospora crassa

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