Conserved Protein Domain Family
BAR_DNMBP

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cd07589: BAR_DNMBP 
The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. DyNamin Binding Protein (DNMBP), also called Tuba, is a Cdc42-specific Guanine nucleotide Exchange Factor (GEF) that binds dynamin and various actin regulatory proteins. It serves as a link between dynamin function, Rho GTPase signaling, and actin dynamics. It plays an important role in regulating cell junction configuration. DNMBP contains BAR and SH3 domains as well as a Dbl Homology domain (DH domain), which harbors GEF activity. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions. The BAR domain of DNMBP may be involved in binding to membranes. The gene encoding DNMBP is a candidate gene for late onset Alzheimer's disease.
Statistics
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PSSM-Id: 153273
View PSSM: cd07589
Aligned: 27 rows
Threshold Bit Score: 167.11
Threshold Setting Gi: 212659242
Created: 1-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #  ##   # ##  ## ##                ## ##  ## ##  #                  
Q6XZF7       1017 QIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHiresa---cvkvVAAVSMWDVCMERGHRDle--------------- 1078 human
EED56701     1393 LVEDKEYDALSQRFGDNFFQLQVVMRDAEGYTREvqgsidclgeitSAIEEFIKVAPTAYHEIegk-------------- 1458 Aspergillus f...
XP_002148490 1512 MYEDTDYNVLANRFNEHFFQLQVVMRDVEMYTREiksgmerfndyiAAIQGYMDVAQSNYTEIesk-------------- 1577 Penicillium m...
EEH04417     1468 VFEDKEFSILSSRFSDNFFQLQLIMRDVELYTTEvqtsikkfhdyiLAIEAYISVAPSNYPELesk-------------- 1533 Ajellomyces c...
XP_001561237 1406 PHDDEVFVKLHEKFGHDYLRLQVVMRDVEYYTRQvatwvndflrflSAMEVVMRHSPSSHPEMear-------------- 1471 Botryotinia f...
CAP78974      426 IFKDKDYEALARRFGYERLQLQLVLRDVEEYIKEaensmarfneliTAMEGIAEVVQFNYSELesk-------------- 491  Penicillium c...
EEH21347     1201 TIWLKECRDWAVDLTSAWNLDSLLVKPVQRIVKYp-----------LLLTELLGTTPPDHPDHaaltnalrettsisvri 1269 Paracoccidioi...
XP_001794031 1005 TFKDQDYKSREQKFGGHFFQLQIVIRDFEQYLDAitehyqqlnivfIGFVSVCEVAPSVHPELest-------------- 1070 Phaeosphaeria...
EEH45876      911 EFRDKDCDVLTQKLGESFFQMQLVMMDVKKYTAEvqsstdrlkqivSAIAEFVSVMPTNYPGLvsk-------------- 976  Paracoccidioi...
XP_760624    1639 LADDGQYKELVAQFRQLEKATSTFAKRCLAWSASv----------kDAHIAQLQLLGSWSRTFavdgmia---------- 1698 Ustilago mayd...
Feature 1                               #  ##                                                     
Q6XZF7       1079 --------------------qFERVHRYISDQLFTNFKERTERLVISPLNQLLS----MFTGPHKLVQKRFDKLLDFYNC 1134 human
EED56701     1459 ------------------cdeLRAVVQGVLTEALPNHIAVVRKSVIDPMVTLLK----LHDGPQRVMKKRDKRLMDYARF 1516 Aspergillus f...
XP_002148490 1578 ------------------whrLRVFVREIMNVALPEHVTTVRKGVIDPMLTLLK----LYEGPQKVMTKRDKRLLDYARY 1635 Penicillium m...
EEH04417     1534 ------------------wcrFRLAVKDVLTVALVDHVSAVRKNVILPMVTLLK----LHDGPQRVMQKRNKRLMDYVRY 1591 Ajellomyces c...
XP_001561237 1472 ------------------wtqFNLSMRDMGSVALESHVGQIRKEVIEPIEAVIR----LYSGPTEFMKKRAKRRVDYEKL 1529 Botryotinia f...
CAP78974      492 ------------------wrlFKRSVWGITTKALPEHLDVIRKSVLAPMTTLIQ----TYEEPQRTMRKRDKWLLDYARF 549  Penicillium c...
EEH21347     1270 ndmkkradvvgqiisgplldyLVGKRNANGLLFLVSQVSTVRKSVILPMITLLK----LHDGPQRVMQKRNKRLMDYVRY 1345 Paracoccidioi...
XP_001794031 1071 ------------------wrkWAMAHFELQNKALEDHKTAVRNRVLKPVADLWE----MWVAYQKTIEQRKKYLLYYVKH 1128 Phaeosphaeria...
EEH45876      977 ------------------wvrWRSCMQGIISGALVDHITLVRTTIIEPLDAALK----LHSKPQAVSQERTMRFPQYVRF 1034 Paracoccidioi...
XP_760624    1699 --------------nteaearVCAFVQLVETTFLGEFWSQLDVEFRTSLIPALQriaaLFSLPQAVIAKRDDREPDYTRY 1764 Ustilago mayd...
Feature 1                                           #  ## #    #  ## ##  ##  ## ##         ## ##  
Q6XZF7       1135 TERaeklkdkKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQ-------LKPLLSL 1207 human
EED56701     1517 KSIker--gdKPDKKTTEQGEQFVALNEALKDELPKLYSLTAKLMEACLKSFVHIQTSWFKTLQDK-------LCPLVDS 1587 Aspergillus f...
XP_002148490 1636 KSIidr--gdKPDKRTTEQGEQFSVLNDALKDELPRLFTLTAKLMEACLKKFVSIQEGWYQVLQQK-------LGPILDR 1706 Penicillium m...
EEH04417     1592 KTLker--gdRADKKTTEQGEQFIALNVTLKEELPKLIALTGKLTDACLHNFVELQKTWLSLIQKR-------LGYIFER 1662 Ajellomyces c...
XP_001561237 1530 MAVkan--gkKPDEKLQLLAKEYDALNETLKTDMPRLSVLTAQIGQTILAKLIFSQTAWYYIWQEK-------VKTVLDA 1600 Botryotinia f...
CAP78974      550 KVVeaq--agKTDKKIAEEGEQFVALNESLKNELARLKGLTAKLAEACLKNLVQFQTTWYSMLQTK-------NRAHAEL 620  Penicillium c...
EEH21347     1346 KTLkdr--gdKADKKTIEQGEQFIALNVTLKEELTKLFDLTGKLTEACLNNFVEIQKTWLGLIEKR-------LGYIIER 1416 Paracoccidioi...
XP_001794031 1129 KQAidr--geKVDPDLEESANKFTTINDTLKHELPLLYERTKGLMRTLMTLFMCLQKDWYKTCSKK-------ILPLLES 1199 Phaeosphaeria...
EEH45876     1035 KVAkgr--niKLDKKTTEKAQQFIALNETLKDELPKFFTLCARLVETCLKNLVHIQNGWFRQLETE-------LGTVIDS 1105 Paracoccidioi...
XP_760624    1765 RAEttrgsskTVDKKLTESANAFIALHMQLMNELPQFNYGVQTLLDLCIESLSRTQASYHLGVHRAligfwqeYGPEGNT 1844 Ustilago mayd...
Feature 1          
Q6XZF7       1208 L 1208 human
EED56701     1588 F 1588 Aspergillus flavus NRRL3357
XP_002148490 1707 F 1707 Penicillium marneffei ATCC 18224
EEH04417     1663 T 1663 Ajellomyces capsulatus G186AR
XP_001561237 1601 N 1601 Botryotinia fuckeliana B05.10
CAP78974      621 F 621  Penicillium chrysogenum Wisconsin 54-1255
EEH21347     1417 I 1417 Paracoccidioides brasiliensis Pb03
XP_001794031 1200 E 1200 Phaeosphaeria nodorum SN15
EEH45876     1106 P 1106 Paracoccidioides brasiliensis Pb18
XP_760624    1845 D 1845 Ustilago maydis 521

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