Conserved Protein Domain Family
nitrilase_8

?
cd07586: nitrilase_8 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
?
PSSM-Id: 143610
View PSSM: cd07586
Aligned: 17 rows
Threshold Bit Score: 325.397
Threshold Setting Gi: 218243433
Created: 22-May-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                        
ZP_03493121    7 RVAIAQFApkLGDVSANLSRHLDYVNEAKranAQVLVFPELGLTGYQTQDLT---LEVARhVSHPDIQRLIQAs------ 77  Alicyclobacillu...
ZP_04507529    2 RVALAQTDcrLGDVEGNLADAERIIKQAAereADLVVFPELSLTGYALGRLTdnvSDISLwPDDPRLAALSRH------- 74  Saccharomonospo...
ZP_02882933   15 KVAAAQIDssYGDLDTNLGKHLSMIDEARrrgVAMLLFPELSLCGHSAGKDA---LQLAMrVDHPAIAALAQAs------ 85  Burkholderia gr...
YP_574400      9 RLAAAQMNcvLADVACNLETHRRVIESARhreVDVLVFPELSLTGYNLGARV---PEVAMdRDDPRLLQLADAa------ 79  Chromohalobacte...
NP_662379      5 KLRIVQADctLANFEENLERHIKAIETAIrdgADAIAFPELSLTGYNVQDAA---QDMAMhIDDRRLDALRELs------ 75  Chlorobium tepi...
YP_001996550   4 KLRIAQIDsvLANFDENLKKHIEHIEAAIadgIEMIVFPELSLTGYNVQDAA---QDIAMpITDQRLQPLSKLs------ 74  Chloroherpeton ...
NP_951708      4 TVALAQIKpkLGCVADNCLMVRQAVERGIdekADLVVFPELALTGYFLKDLV---PDVALrLDAPEINALRELs------ 74  Geobacter sulfu...
YP_574407      8 RVGAAQINasLGDVDANLERHLAFIADARrkgLELLVFPELSLTGYGLGNRV---IDVACpAHDPRLAELARAa------ 78  Chromohalobacte...
YP_918645     23 TIGAAQFSseIGDVDANLDRHLHWIARGReagLDMLVMPELSLTGHYGSENL---LDAAMsRKDPRLKRLAEAa------ 93  Paracoccus deni...
EED09962       3 RHAVLQFRpeKSRLKESLLRLRAHLEALRphaPEVVVLPEAALTGYFLQGGV---RELAL-TRHELLELFSELhqalgwe 78  Thermus aquatic...
Feature 1                                            #   #      #                         ## ##  
ZP_03493121   78 rDLDVLFSFVEEtddcrFFVTAAYA-SGGRLvHRHRKLYLPTYGMFDERRYFAPGDrvRTFSAqg-gQAGVLICEDAWHL 155 Alicyclobacillu...
ZP_04507529   75 -GPDVVIGLLEDgr-irRHNSALYL-SNGALvHNHRKLYLPNYLIWEERKHASPGQhmRAFDTrh-gRFATLVCNDAWQP 150 Saccharomonospo...
ZP_02882933   86 vGLHTSFGFIEEapggqFYNSQASV-TEGAIvHVHRKIQLATYGKLRDGLYYAPGAdlGAFGIdrdwRVATPICNDLWNP 164 Burkholderia gr...
YP_574400     80 gDMLTVVGFVERcargeYANAMACL-CEGRVvAVHRKLNLCTYGGHEEGKHFGKGQtlTVTDAdg-lACGVMICADLWNP 157 Chromohalobacte...
NP_662379     76 rDICIFCGGIELsddygVYNSAFMF-EDGAGrSVHRKIYLPTYGMFEELRYFSAGRqiETVTSrrigKVGVAICEDFWHM 154 Chlorobium tepi...
YP_001996550  75 eKISILCGGIELsedfgVYNSAFFF-EDGEAkSVHRKIYLPTYGMFEELRYFSAGHhvRAFNSrklgKIGVAICEDCWHM 153 Chloroherpeton ...
NP_951708     75 rHISIAVGLVEVsadyrFFNTSLYL-EGGEVrHVHRKVYLPTYGLFDEQRYLARGEhfRAFDSrf-gRMGLLICEDMWHL 152 Geobacter sulfu...
YP_574407     79 gEMQVVVGFVEEaspgeYYNALAIL-QHGKLqAVHRKLNLPTYGGLEEGKLFTHGSelTHLPVcpgwSATSLICADLWNP 157 Chromohalobacte...
YP_918645     94 gPMAVTLGFIEEgpaaqFYNAAAIL-CDGRMiHLHRKVNLPTYGKLEEGKHYAPGRfvETCELdgywRAGLLICADVWNP 172 Paracoccus deni...
EED09962      79 gLLDVVVGFYERdg-gaYYNSAAYLeLPHRVvHVHRKVFLPTYGVFDEERYLARGSrvAAFTTrf-gRAAILICEDFWHS 156 Thermus aquatic...
Feature 1                          #                                                             
ZP_03493121  156 SSPYLLAvqGASVIYVPASSPwrntmaaSDFGSHAFWRQLLQVYAQLCGCFFVFANRVGYEDGVHFYGGSGVMGPdGEWV 235 Alicyclobacillu...
ZP_04507529  151 MLPWLAAqdGAELLIVPANSAakp--tgGSFDPAEYWHDLLTFTARMQQCWVVFVNRVGDEAGVRFWGGSRVLDPwGSVV 228 Saccharomonospo...
ZP_02882933  165 ALVHDLMcdGVTLLAAPISSArea--vgGGFDNPSAWELNLRFYAVTYGVAVVMANRIGTEGMLRFWGGSRILDPfGNTV 242 Burkholderia gr...
YP_574400    158 GLAHAAMleRPDVMLAPVNAAtgm--vdGDFDDEGNWLICLKFYAMMYATPMVMAHRYGAEGDGWFWGGSCIVGVdGRVL 235 Chromohalobacte...
NP_662379    155 SVPYLLAhqGAKLLLVLMSSPlrlspgqGVPAIVTQWQTIASTSAFLLSCYVACVNRVGNEDSFTYWGNSAVTTPdGSIA 234 Chlorobium tepi...
YP_001996550 154 SVPYLHAvqGAKVIFAMMSSPlrvdlqtGELGIARVWEMLNRTYAHLFSVYLVCANRVGNEDSLSYWGNSEIIAPdGNSV 233 Chloroherpeton ...
NP_951708    153 SAPYILAmdGATTVICLSSSPgrgltedDSLGSTIAWQKLTSTTAMFFNCRVLYCNRVGYEDGVNFWGGSEVVAPsGAVT 232 Geobacter sulfu...
YP_574407    158 GLVHAALlaRPTVLCAPINSAsgi--vsDDFSNEQNWAVNLQFYAMTYGTPVIMANRFGPEGNSHFWGGSRILGPrGDTL 235 Chromohalobacte...
YP_918645    173 ALTHLAFlhGATLLICPVSSGeea--vgVDFDNPGGWALTCRFYAMIYGAPVVMVNRTGTERDLTFWGGSRIIDPfGRAL 250 Paracoccus deni...
EED09962     157 ITAAIAAldGAEVIYVPAASParg-fqgERPENVERWRNLARAVAAEHGVYVVLASLVGFEAGKGMSGGSLAVGPdGRVL 235 Thermus aquatic...
Feature 1                                                  
ZP_03493121  236 AEGPASesAMVVADLDFRMVRRARyttplmrDERVRLVLAEM 277 Alicyclobacillus acidocaldarius LAA1
ZP_04507529  229 TAAPDWeeSLTVVDIDLRAVRKRRheipllaDARMGLLRREL 270 Saccharomonospora viridis DSM 43017
ZP_02882933  243 AMGSTTdeELVVGELDYAALREARfllptvrDARVYAARGIR 284 Burkholderia graminis C4D1M
YP_574400    236 ARAEDSe-TLVSADIDTDEIDAARfampthrDADTPLVASLM 276 Chromohalobacter salexigens DSM 3043
NP_662379    235 ASAPMFseHSFDATIDYSVVKRVRlqsshflDEDTKLFASQL 276 Chlorobium tepidum TLS
YP_001996550 234 VRGPLFeeALLDGEIDFSQVRRTRlhsshflDEDLRLISSEL 275 Chloroherpeton thalassium ATCC 35110
NP_951708    233 SRARILeeDFLVAGVDEGALRRERifspmmrDESLLITLSEL 274 Geobacter sulfurreducens PCA
YP_574407    236 ALAEDGe-TLIEAQLSRTAIARARfelpthrDADTPLVRELM 276 Chromohalobacter salexigens DSM 3043
YP_918645    251 AVAGSGe-EMITATLDYDVLRRARhllptvrDSNLALVQRET 291 Paracoccus denitrificans PD1222
EED09962     236 AEAPLFeeAALLFALDRERIPPVRydapllsDLEASLPLLLP 277 Thermus aquaticus Y51MC23

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap