Conserved Protein Domain Family
nitrilase_6

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cd07584: nitrilase_6 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143608
View PSSM: cd07584
Aligned: 8 rows
Threshold Bit Score: 393.658
Threshold Setting Gi: 188586226
Created: 8-May-2009
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                        
YP_001112901   6 TIGLIQMDcvlgdVAANVAKAIERIRQAAamgAQIICLPELCTTGYrpdlledklw-eltepvpgptTDVFSQLAKELGI 84  Desulfotomaculu...
YP_001917771   3 QVAAIQMTpimndVDGNIKRGVHLAKNAIaeeADLIVFPELWTTGYhlsresfra---laekpdgktVSTFQEIAKQGEV 79  Natranaerobius ...
ZP_01802219   17 KIGIIQQHsvlgdVKKNIEKAVEMIDDLGkhgADIICLPELFATGYnleslggvktlelirehnkyiEESMSEAAKRNNV 96  Clostridium dif...
ZP_02205731   43 KAAAVNMDcelgnVKANLKKMADFCKEAStkgALAICFPELATTGYsptilgekyy-eisepipgpsTNYLCKVAKATGL 121 Coprococcus eut...
YP_454820      3 KVALAQIDtelgnKRKNLRYIASLCKEAAdnkADVICFPELATTGYtpdllgtrlw-hlsesrgeetDQLLSQLAGELGL 81  Sodalis glossin...
ZP_03640014    7 KVALAQFDselgnKTNNLQRMAQLCQQAAdsgAKLICFPELATTGYrgdllttklw-dlsdsigsetYTLFSELATRLNI 85  Providencia ret...
ZP_03894657   14 HLALVQFEsvlcdPAANTQKACRMIAEAAaegADLVVLPELFSTGYelnivgphvp-elaepvdgptVRALQDAARAGNC 92  Eggerthella len...
YP_455158      3 TLALVQTDaylgeKRRNLERLQTFCHTAKkegAQLICFPELATTGYaptllgpeyh-alsetrqgetNRMFSALATELGV 81  Sodalis glossin...
Feature 1                                               #   #  #                          ## ##  
YP_001112901  85 YIIlPMN--EKgavpgmiHNSAVFI--DKDGEv-qGVFRKAHAYaTERYYFTDGNh--yPVFQTefgKVGVMICYDMGFP 157 Desulfotomaculu...
YP_001917771  80 SIVcPFV--EEagd--kiYIAAAVI--DTEGEt-rGIVRKSLLWgREQQIFNAGVme-yPTFDSkvgKIGILICYEMEFP 151 Natranaerobius ...
ZP_01802219   97 YLIsPYGtlEKgst--hvYNSAVIF--DRKGKi-mGEYCKNHLWsLEAVYFKGGEk--vEVYDAdfgRFGVMICYDAGFP 169 Clostridium dif...
ZP_02205731  122 YIVtGIS--EKsgvpgrlYNSQIAI--SPEGKi-vSIYRKIHVWgLEKLTWRESItceyGTFDMpmcKAGHMICYDTSFP 196 Coprococcus eut...
YP_454820     82 HIIaGFV--ERgertgqvYNSAGVW--APEGQswlHAQRKIHLWgDEKKWFSEGEq--yEIIATplgKIGVMVCYDLGFP 155 Sodalis glossin...
ZP_03640014   86 TIVsGFV--ERgeylgdiYNSVGVWnpGCEGIs--GVFRKVHAFgIEKQWFGRGDs--fPVFETpigKIGIMICYDMGFP 159 Providencia ret...
ZP_03894657   93 YVVaGLA--LAydmagvpFNSSVVI--DRQGEl-lGTYDKQHLWaLERFYFRSGCd--cPVFDTdfgRIGVMICYDMGFP 165 Eggerthella len...
YP_455158     82 IIVcGFI--ERdmqtdavYNAAGVW--LPGQEswlGVFRKMHLIqEEKRWFTPGQq--lRVFDTplgRIGGMICYDAGFP 155 Sodalis glossin...
Feature 1                          #                                                             
YP_001112901 158 EvARILTLkgAEVIFAPSAwrqedediWDINIAARALENRLFVAAVNRVGregdvvmhGKSKIANTrGKTLAEAArfeeD 237 Desulfotomaculu...
YP_001917771 152 EtSRLLALegAEVIVCPSVwsmsaahrWEIQLPARALDNTVFVLGVNTVGnn----scGKSKLLSPmGDVLAEASgrkeE 227 Natranaerobius ...
ZP_01802219  170 EvSRELTLkgSEIIFIPSAwriqdedmWDLNVSQRALENTVYTVGVNLVSndsnlilfGKSKICNPrGTVITQLDtyreK 249 Clostridium dif...
ZP_02205731  197 EtARVLSLmgSNVIFDSAAwrnleadiWELNTRARAVENHVFMICSNRCGvegdstlnGESRIIGPrGNVLAAAGhe-eE 275 Coprococcus eut...
YP_454820    156 EvARIFALrqVDILFVIAAwseaeayiWDINCAARALENGVFLVAVNRWGeegdlrlfGGSQIMAPdGQCVVRATdkgeA 235 Sodalis glossin...
ZP_03640014  160 EvARILTLqgAELLLAPSAwcvqdrdvWDINSACRALENGTHLLAVNRWGheedlhlfGGSKVLGPrGQVLCEAScegeE 239 Providencia ret...
ZP_03894657  166 EvARMLALqgADLILCPSAwcqedmdvWDVNAPARALENTAFVAAVNRYGvedqlvmpGHTKVCNPrGHVVAELAeeaeG 245 Eggerthella len...
YP_455158    156 EvARSLTLkqADSLLLLSAwpekdkdiWYINGPCRALENTIYLAAVNRWGregdcqlfGGSQILNPrGQVMARATehaeQ 235 Sodalis glossin...
Feature 1                                     
YP_001112901 238 ILVATVDLHe--LIAGRRet-pYLKDRKP 263 Desulfotomaculum reducens MI-1
YP_001917771 228 ILIRAIDKE---ALLWARdevsYLEDYKT 253 Natranaerobius thermophilus JW/NM-WN-LF
ZP_01802219  250 YVLSEIDLD---EIKKYRedipYLKDRKS 275 Clostridium difficile QCD-32g58
ZP_02205731  276 IIYADIDIDs--CIKDNAmmlsYMKDRRP 302 Coprococcus eutactus ATCC 27759
YP_454820    236 LVYGNIDLS---QLANVRmtlpYRKDVKI 261 Sodalis glossinidius str. 'morsitans'
ZP_03640014  240 LLIGEVDFL---NQAHTRlkvpYLRDRKP 265 Providencia rettgeri DSM 1131
ZP_03894657  246 VLHVELDLN---EVVDYRqrspYLRDRRP 271 Eggerthella lenta DSM 2243
YP_455158    236 ILYHTIDKQvqsAIRHTLp---YLADRQP 261 Sodalis glossinidius str. 'morsitans'

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