Conserved Protein Domain Family
nitrilase_5

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cd07583: nitrilase_5 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143607
View PSSM: cd07583
Aligned: 75 rows
Threshold Bit Score: 302.15
Threshold Setting Gi: 187933889
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                   #                                    
O31664         4 TISCLQFDIsyGKPSENIKKAEFFIEKESk-----hADVLVLPELWTTGYdlanldeladedgrsaQSWLKKTAKKHGVH 78  Bacillus subtil...
AAR37873       2 KVATISLNIawQDVEKNLERAEKFVLQAKad----gCDVVVLPEVFNTGFiadvgkya-elpncktHHALQQFALNNLIN 76  uncultured mari...
ZP_01910989    2 KLAALQTDIawEDPQANFERLRPQIAGAAas----gARMVVLPEMYACGFsmdtqaia-epfegpsVGFLREQARAHGLW 76  Plesiocystis pa...
ZP_03131352    5 NLYAVQLDIvwEDKAANFRKVEALVDAAApa----pGSLVVLPEMFSCGFsmnlavtr-qgaeredEAFIAALARKHGVF 79  Chthoniobacter ...
ZP_03718152    2 RIGMAQMDIswENIEDNKEKVEQFFKKAEen----qVDCLVFPEMTLTGFsmnveet--geksenqKHFFEEMSKKYKIL 75  Eubacterium hal...
ZP_02949480    2 IIGIVQMDIewEDIYRNMNKIEGFVKEACek----kIELLLFPEMSLTGFtmdidkh--tfsekeiSNWISKIAVRYSMN 75  Clostridium but...
YP_001038704   2 RAALYQMEIawEDKEKNYKKLEGVSEEVKkh----gADLLLLPEMSFTGFsmntklt--keyndesKDRVKMICKSHQIS 75  Clostridium the...
NP_710405      7 NVALIQCDLswENQKANYEHVRNLIHSTLeknsnkkPDLILLPETFATGFtmrseria-eadegptETFLQEIANFTRAT 85  Leptospira inte...
YP_393116      2 KIALISLNQiwEDKDKNLILCEKNIQKAVeg----kADLIIFPEMTLTGFsnnipfiveniedsktIKEFSSLAKKYNTA 77  Sulfurimonas de...
YP_001887501   2 IIGIGQIDVlwEDYFANMKKIKILVEEASik----dVELILFPEMALTGVtldiekl--ilerdeiVSWCRELAIKNNIN 75  Clostridium bot...
Feature 1                                                  #   #    #                        ## #
O31664        79 IVaGSVAVRkn----------sdVYNTMYIADKEGqIIKEYRKAHLFqlmDEHLYLSAGSedGYFELdgvKSSGLICYDI 148 Bacillus subtil...
AAR37873      77 IVaGASEKKpn----------ekAHNIALVFDSHGnEVAKYSKLHPFnyaNEGKYFASGNetIKFELdgvACSVFICYDL 146 uncultured mari...
ZP_01910989   77 MA-ASVPVLaptevgsasspgakPSNTFVLAGPAG-EVHRYAKRHPFtfaKEHEHYAAGEdtLTVTIegvRVSAFICYDL 154 Plesiocystis pa...
ZP_03131352   80 ITgGVVSRGag----------emGRNDAVVFSPEGkLVARYTKIHPFsggGESQGHEAGSeiVTFEWggfVVAPFVCYDL 149 Chthoniobacter ...
ZP_03718152   76 TVfGYTEPVpeerlke-hpnwnhYYNRLGIAENGE-LKLNYAKIHPFsygFEGEYYQGGRklKSVEWkgtTLGAFVCYDL 153 Eubacterium hal...
ZP_02949480   76 IGiGFGVIVde-----------kGLNKYMIVSNEGnIIADYSKIHPFsygGEDKKYYKGNdiIDCSLkdiNITPFICYDL 144 Clostridium but...
YP_001038704  76 IGfGWVKAAge-----------kAENHYTIINEKGdEISDYVKIHPFsmaGEEKYFVKGNklSTCKLqgrEIATFICYDL 144 Clostridium the...
NP_710405     86 ICaGWIRKNqn----------gkPFNTVSVVNPNGiIILRYSKIYPFtfgGENRHYSAGSeiLSYNLngfRITPFICYDI 155 Leptospira inte...
YP_393116     78 LVfGVAIKDgd-----------kALNKAVFIDKNGsVLGKYSKIHPFtfaGEDKYFNAGNslEIVNFenfKIGLTICYDL 146 Sulfurimonas de...
YP_001887501  76 IGlGYGKKIdn-----------kGLNNYIIISNLGeVLCDYSKIHLFtygGEPKAYYNGMnvLDYQIggfTMSSFICYDL 144 Clostridium bot...
Feature 1        #                     #                                                         
O31664       149 RFPE-WIRKHTtkGANVLFISAEWPLpRLDHWKSLLIARAIENQCFVAACNc-tGSNPDNEFa---GHSLIIDPWGRVLA 223 Bacillus subtil...
AAR37873     147 RFPE-IFRQIAk-EVEVIFVVANWPHtREMHWQNLLIARAIENQCFIVGVNrigNDGVGLKYn---GSSMVINPLGEVLL 221 uncultured mari...
ZP_01910989  155 RFADeFWRLAH--DTDLYVVVANWPQkRRMHWQTLLRARAIENQAWVVGVNr-vGEGSGLAYs---GDSMIIDPWGEVVA 228 Plesiocystis pa...
ZP_03131352  150 RFPE-IFRAAArkGANLFVVMALWPVkRQQHWLTLLQARAIENQAYAVGVNr-vGREPELLYa---GRSVVVDPHGVIIA 224 Chthoniobacter ...
ZP_03718152  154 RFPE-IFQISSe-KSEIIFVIANWPKsRIDQWDTLLKARAIENQVFMVGVNr-tGEGDGLHYn---GHSAIYSPNGEAVT 227 Eubacterium hal...
ZP_02949480  145 RFPE-IFQIASk-KSELICVAANWPGkRENHWITLLIARAIENQCYIAGINr-vGTGDGIYYn---GASMIIDPEGNVLN 218 Clostridium but...
YP_001038704 145 RFPA-VFQALGd-ETEIVVVAANWPKkRREHWKCLLQARAIENQVYILGVNc-vGNMGGLEYs---GDSCVINPNGEIIE 218 Clostridium the...
NP_710405    156 RFPE-IFRKVAg-ETDIFTIHANWPVpRIHHWELILKTRAIENQAYVFGVNr-iGVAGYNQSishnGHSLAVAPNGDFVD 232 Leptospira inte...
YP_393116    147 RFPE-LYSSLAk-SCDLVINIANWPFkRVAHWNTLLKARAIENQIFIAGINr-vGVDGNNLEy--cESSNMFNANGEQVY 221 Sulfurimonas de...
YP_001887501 145 RFPE-IFQLAAr-KAQVITIAANWPEsKIDEWISFLKVRALETQSYIIGINr-lGEGDGIKYn---GKSAIVSPWGDILN 218 Clostridium bot...
Feature 1                                        
O31664       224 EGGreEGIVRAEIDLQESAEVRESIPVFDDIR 255 Bacillus subtilis subsp. subtilis str. SMY
AAR37873     222 QTDkeTEYASCDIDTSMVSKTRKDFPFLEDIR 253 uncultured marine bacterium 560
ZP_01910989  229 AASrdATTLLAEISAARVADARRKFPVLEDRR 260 Plesiocystis pacifica SIR-1
ZP_03131352  225 DAGerEHILPATLEPEVVHSWRRDFPALRDAH 256 Chthoniobacter flavus Ellin428
ZP_03718152  228 TIReeECLLIGDINPEEIKEMRKTFPMKNDRR 259 Eubacterium hallii DSM 3353
ZP_02949480  219 EITsdEGIITADICKEKVLNIRKSFSLKKDRR 250 Clostridium butyricum 5521
YP_001038704 219 IIEd-KEGVIYADIEQDVKKIRDSFPLRLDRR 249 Clostridium thermocellum ATCC 27405
NP_710405    233 AGEgnETILFYKAHKNSISDYRKDFPVLLDRK 264 Leptospira interrogans serovar Lai str. 56601
YP_393116    222 FEQi-DEMKLYEIEKDWTKEFKSKFNTTNDRK 252 Sulfurimonas denitrificans DSM 1251
YP_001887501 219 DLSdkEELVIQEIKLEQVFKSRAKFNVKDDRR 250 Clostridium botulinum B str. Eklund 17B

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