Conserved Protein Domain Family
nitrilase_4

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cd07582: nitrilase_4 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143606
View PSSM: cd07582
Aligned: 10 rows
Threshold Bit Score: 376.684
Threshold Setting Gi: 182414759
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                  #                     
YP_831408      5 FVVVAVSPRtin-------vknPGDGVANVKRINEFIDTAVMVgawe-gspVKLVVLPEMAIQgmmantpgnrkk--eah 74  Arthrobacter sp...
YP_759834     34 YTALALQTVceavnqdktaeasHARMNAAITRVTGQIMASRGFlkgfngydLKLVVLPEYWMTgfpmgetretwq---ak 110 Hyphomonas nept...
YP_001819825   3 YAVAACQTDfac-------ptdRREISARVDRMLAMIDGAVVGyrp--ffpVRLVVFPEFAHAapiyatvrelr----dk 69  Opitutus terrae...
YP_516609      5 YMALAIQPTmrg-------aekREDIKRNIAHISDVIDAAVWLsgi--empVRLITIPEGALQgftdelfdwdhqyyvdh 75  Desulfitobacter...
ZP_03320761    5 YGVVGLVPTtwg-------iktRSDIMKNIDHLEELSHGALWLssl--dlpVRLLVLPEGALQgfndealdlpiaeflkd 75  Providencia alc...
YP_001433573  29 YRALALQVTchavnalnnrvavREQMLATIVRLREQIRASIAFig----ndVRLVVLPEYFLTgfplgesiavws---ek 101 Roseiflexus cas...
NP_489063     11 FRALALQVTchavnqasdrqeaGLMMHNTINRLAQQIAASIAFig----fdCRLIVLPEYFLTgfpmgeplqvwa---dk 83  Nostoc sp. PCC ...
YP_001262196   9 YTALVMQPHvev-------aedRAGIAKNLDRAINMIDFGVGYfwe---lpARLVVFPEYFMQgvttpgkgehgidsfmk 78  Sphingomonas wi...
YP_661081      5 YTAVALQTRcfavnk-lnvadaRQKIFDNIRRVGRHVQGTKGFvg----psVKMVVLPEYFLTsfpmgeslaqwk---ek 76  Pseudoalteromon...
YP_002822337   5 YTAVALSTRnya-------vktTKESLENIKRINDFMDVAVMVaatd-gapVRLIVLPEMAIQgmpmdfragnkeq-hes 75  Rhizobium sp. N...
Feature 1                                                                   #   #                
YP_831408     75 favtipgpeTDELAKKAVELNTYIAaELY-MVkDEDFPDRHFNVAFIIDPQGeIIYKRYKATSDayeggmlgnmnPHDVW 153 Arthrobacter sp...
YP_759834    111 aaipmdgafPDALAKMAQTAGVYLCsNHY-ET-DPNFPELYFQANVIYGPTGdTLLRYRRMISLys-------psPYDVW 181 Hyphomonas nept...
YP_001819825  70 lavpvpnehTARYHAKARELGIYIQtGTFiES-DPAHPGVLFNTSCLIGPEG-ILTKYRKVNPWi----------PWEVH 137 Opitutus terrae...
YP_516609     76 maidipgeeTELLGKKAKEYNAYLIaQAK-VK-HPEFPGRFFNSAFLIDPKGeVILQSYKMQVFcqeh----stvPHDVW 149 Desulfitobacter...
ZP_03320761   76 gaidipgpeTDRLGELAKSQNVYIMaQAK-TR-DPDWPGIMFNVGFIIDPKGnIILKHHKMSSLlpce---rsasPHDLY 150 Providencia alc...
YP_001433573 102 aaidpdgpeYAALGQIACDLQIFLAgNCY-ER-DPHFPGLYFQVSFVIDPSGqCVLRYRRLNSMfa-------ptPHDVW 172 Roseiflexus cas...
NP_489063     84 acleingaeYEALGMIAQKQQIFLAgNAY-EL-DPNFPGLYFQTCFVIDPSGsVVLRYRRLNSLfa-------ptPHDVW 154 Nostoc sp. PCC ...
YP_001262196  79 kaieldgpeMRRLGEVAKEYNLYIAgGGVvER-VKEFPDRWFNTAFIIGPSGeVVLRYHKWHIPasig---lgtsPHDIF 154 Sphingomonas wi...
YP_661081     77 gaiaqdgkeYELLSEIAQKNQVYLSgNVY-EL-DPHFKDLYFQTSFILGPNGdCILRYRRLVSMfa-------ptPHDVL 147 Pseudoalteromon...
YP_002822337  76 aattipgpeTEALAVKAKQFNAYIAaELLwVR-DDDFPGHLFNVGFIINPQGeIIYRRAKATSDayeggalgttnPHDIW 154 Rhizobium sp. N...
Feature 1        #                              ## ##                    #                       
YP_831408    154 DEWIEKKGNgnamDAIFPVAKTEIGNIGYAICHEGVYPEvPRGLAmnGAEIIIRGTLiepav----qngmWELQNRAHAM 229 Arthrobacter sp...
YP_759834    182 DKYLDIYGA----DAIFPVAETEIGALATIASEEILYPEiARMHAfkGAEILLHPTSevgsp----sltpKHIAKKARAI 253 Hyphomonas nept...
YP_001819825 138 ASPHDVPGYa---EELFPVAQTELGNLGCAICYDWIFPEaIRALTlnGAEVLIRVSAymdpwgatppmdwWTVVNRCRAL 214 Opitutus terrae...
YP_516609    150 DKWIELYGYk--lDSFYSVADTEIGRIGLLVCQEGDYPEpARGLAmnGAEIIYRSSApepav----angwWELQNRARAL 223 Desulfitobacter...
ZP_03320761  151 DEWIKKYGRs--lQSFWPVVDTEIGRLGIMMAMEGNFPEnGRGLAlnGAEVVYRASLptpft----endlFEISNRARAL 224 Providencia alc...
YP_001433573 173 DRFCQMYGP----DALFPVADTAIGRLACIASEEILFPEvARCLAmrGAEVFLHSSSevssp----eltpKHIAKRARAL 244 Roseiflexus cas...
NP_489063    155 DKYLDCYGL----EGVFPVAKTAIGNLAALASEEILYPEvARCLAmrGAEIFLHSTSevysk----nltpKDAAKITRAV 226 Nostoc sp. PCC ...
YP_001262196 155 DEYKEVFGGd--iSTLFPVIDTEIGKLGTMTCHDGCTPEvSRALGynGVEVICHPVAlqevegvsqpwdfWMFTRRTRAH 232 Sphingomonas wi...
YP_661081    148 DKYLDVYGQ----SSLFPVAKTELGNLACVASEEILYPEiSRCLVmnGAEVLLHSSSevgsv----eltpKDIAKRARAV 219 Pseudoalteromon...
YP_002822337 155 EEWVEKKGNgsklDAFFPVARTEIGNIGYLICHEGAYPEtARGLAmnGCEIMIRATLiepqv----mqgmWELQNRAHAM 230 Rhizobium sp. N...
Feature 1                                                                                        
YP_831408    230 FNSAYIVAPNlgpevrdd--gsmqdlfgGQSMIVGPrGQILTKQQgwtsgdSFVCTTIDIEALRRARvanglynqfKDLR 307 Arthrobacter sp...
YP_759834    254 ENISYVVSANsasitgtp---vpaastdGMSIVLDWyGRTLAEAGtg--etMNANAVLDLTALRETRrktgmtntlSRLP 328 Hyphomonas nept...
YP_001819825 215 ENLAYVVAANqgaslqh----ygpfswpGGSMVVDYdGRILAQADpgp-geKIVVAEIDLDALRAARarrlghnplAHLR 289 Opitutus terrae...
YP_516609    224 DNTCYVVAPNvatyypsqaaelsvdtfgGQSMIVNHhGEVISNHKygs-gsSYAGAIIDVESLREYRerslfgnwmKDLR 302 Desulfitobacter...
ZP_03320761  225 ENNFYVVAPNigsmymfpttqapidcggGRSLIVDYkGKIVGKQEdtn-gsTYVYGVIDIEAMRYHRanasvsnwlKDIR 303 Providencia alc...
YP_001433573 245 ENLAYVISANsagisgip---ipaasveGGSQIVDYtGRVLVEAGqg--esMAAHAEIDLAALRRYRrrpgmnnllSRQR 319 Roseiflexus cas...
NP_489063    227 ENMAYVVSANsaglansa---ipigsvdGGSKIIDHrGIILAETGpg--esMAAFAEIDLAALRRDRtrpglnnllSRQR 301 Nostoc sp. PCC ...
YP_001262196 233 DNMAYVLGSNwgtvdyay---ypkafcpGGSFAIDYtGMVQRHAPyp--qeQVLGVTIDIESLREHRsrcn-hntwVDVR 306 Sphingomonas wi...
YP_661081    220 ENLAYVVSANsagiadid---fpaestdGMSKLVDFkGRVMAEAGmg--esMVANAELDITALRRYRnkpgmgnilSRQR 294 Pseudoalteromon...
YP_002822337 231 FNQMMVISPNlgpqvgkd--ggffdvfgGQSMIVDHkGHVLVKQPgmangdSFVSTVVDVEALRRARiangvtnwfKDLR 308 Rhizobium sp. N...
Feature 1         
YP_831408    308 T 308 Arthrobacter sp. FB24
YP_759834    329 L 329 Hyphomonas neptunium ATCC 15444
YP_001819825 290 R 290 Opitutus terrae PB90-1
YP_516609    303 T 303 Desulfitobacterium hafniense Y51
ZP_03320761  304 T 304 Providencia alcalifaciens DSM 30120
YP_001433573 320 F 320 Roseiflexus castenholzii DSM 13941
NP_489063    302 F 302 Nostoc sp. PCC 7120
YP_001262196 307 T 307 Sphingomonas wittichii RW1
YP_661081    295 N 295 Pseudoalteromonas atlantica T6c
YP_002822337 309 T 309 Rhizobium sp. NGR234

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