Conserved Protein Domain Family
nitrilase_3

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cd07581: nitrilase_3 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143605
View PSSM: cd07581
Aligned: 52 rows
Threshold Bit Score: 277.535
Threshold Setting Gi: 124027487
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                        
YP_997595      3 VALGQFAvrpeWQRNADTCLELMAQAGre--rADLLVLPEGVLArditdpdl---vrrsaqpLDGPFVTRLLQASRSApl 77  Verminephrobact...
YP_001013827   6 IALLQFGathsKEESLERIRKLISRYErivseADLLLVPEYSMAdptgqppe--aiaaiaepLEGPWIGFFARLAREY-- 81  Hyperthermus bu...
ZP_02419514    5 AAIAQCRasqePEKNLCKAEFFCREARee--sACFVIFPEYFMTyypiegsa---yyekaqtLDGPFVQGMKRLAAAH-- 77  Anaerostipes ca...
ZP_04498584    5 IALAQSGfp-kKGDAIAQAERYAEKAAaa--gAQLLVFPENFMLpgildseg---vkeisepLDGPFARAMADIALRH-- 76  Slackia heliotr...
ZP_02440403    4 IAVAQTTssgnWRENIEKAKQYIKKATee--eAVMIIFPEYFMNyypdaehn---ytkkaqsLHGEFVQAMKMLAKEF-- 76  Clostridium sp....
YP_920633     18 VALHQLAvsgeKRENLEKALRLLELGD-----AYLHVFPEYLMGvdpggptrd-yvwrvaepIDGEFASRIVEKTGEL-- 89  Thermofilum pen...
NP_148508      3 IAVLQVAstreKDANLESVKRLASRVKn---sPDIVLTPEYLMLdptglgrd--aiydaaedLEGRWSRELSKIAESL-- 75  Aeropyrum perni...
YP_931348      1 MFRLGIAq--iSPGNLDKLRSLVGRSE-----PDLLLLPEYSMFdptglppe---eiwnkavAIEDFTSLIGRLAREL-- 68  Pyrobaculum isl...
YP_002428414   6 IGIVQAGfndlPAENAGKAIDIVRKNYk---eADIVVLPEYSMLnplkigdprlvysysetpLTSRYLTEMAKLAGEL-- 80  Desulfurococcus...
YP_001040235   6 VGILQDEftvdPMENYKRIRELLEEKHq---vADIVVVPEYSMInilaglkpsdvyeraeriNDSIYISKISDLAAKL-- 80  Staphylothermus...
Feature 1                                               #   #      #                            #
YP_997595     78 tGLTVMm-CVHVPaan--dkvFNLLIAL-RDGQiLAQYRKLHLYDAFsAQESANVMPGDev-pPLIEVag--lKLGLMTC 150 Verminephrobact...
YP_001013827  82 -SVHVVatLYEKSkag--gkpYNTAALIaPTGElLAVYRKIHLFDAYgYRESDYFMPGAe---PAKLAtikgfRIALAVC 155 Hyperthermus bu...
ZP_02419514   78 -GQWILfgMSEKPgrdsggkcFNTAVLLdDRGNlCSVYRKTHLFDAFsWKESDSTLPGEvlhePVNTPl---gKAGLGTC 153 Anaerostipes ca...
ZP_04498584   77 -HLWIVyvIFEENpdg--gqpFNTAVTVdAEGVqRGAYRKCHLYDAHgVLESDRSVAGDqlpqPVDTPf---gPLGVAIC 150 Slackia heliotr...
ZP_02440403   77 -KMWIIfgMNEQTvde--tknYNTMVILnDLGElVSDYKKTHLFNAYkWNESMNTLKGDclftPIKTPa---gVIGLGIC 150 Clostridium sp....
YP_920633     90 -GVAAVftMFLREgp----gvYNAAVLA-EEGKvKAVYRKIHLFDAYgYRESSVFSPGRe---PVVADlk-glRLGIAVC 159 Thermofilum pen...
NP_148508     76 -GSCLLghLFLKTpsg---rvANAAVLYsRDGGiIGVYRKTHLFDAYgYVESSFTEPGDelwePRKACg---aSIGVAIC 148 Aeropyrum perni...
YP_931348     69 -GAYVVggFLERGprp---kvYNTTVLVdPGGRvVGLYRKTHLFDAYgYKESEFVEPGAel-sQVYTVrg--aRVAFAVC 141 Pyrobaculum isl...
YP_002428414  81 -GVFILvhFIEKTdtp--pltMSTSIIVtDRGEaIPVYSKMHLFDAYgFRESSFFKPGNv---PGKIIsikgvKIGFTIC 154 Desulfurococcus...
YP_001040235  81 -DTYMLihFIEKTdtp--pktMSSSILVhPSGRiDKVYSKMHLFDAYgYRESDYFLPGRtlsrPLVFNh---vRFYVAIC 154 Staphylothermus...
Feature 1        # ##                     #                                                      
YP_997595    151 YDLRFPElARRLAl-dGAEVLVLPAAWVKGPLKeahWELLLSARALENTCYAVAAGecge-rniGHSMVVDPlGVVVARA 228 Verminephrobact...
YP_001013827 156 FDLRFPElFRTYAl-qGAELVAVPAAWYRGPAKedqLRIIAAARAHENTMYIAVASqyns-nftGRSLVADPyGLVLLDA 233 Hyperthermus bu...
ZP_02419514  154 YDLRFPEpARIQAl-kGAEVLIYPSAWVDGPDKfmqWEALLRARAIENTVFTIGCChyseehymGRSLAFDPsGRKLAEG 232 Anaerostipes ca...
ZP_04498584  151 YDLRFPEvARALAv-aGCKLVLFPSAWNAGPRKvkhWTTLLRARAIENELFVAGIChagk-rytGKTLVADPlGRIVASA 228 Slackia heliotr...
ZP_02440403  151 YDLRFPElARYEAl-sGAQVMLYPAAWVKGKGKfmqWETLLRARAIENEMYVLGCChyskehymGRSTGFAP-DGTRLYL 228 Clostridium sp....
YP_920633    160 FDLRFPElFRSMFl-rGAEVFVVPSAWYRGPYKveqWKALTAARAHENTSYLVAVNqvge-sftGHSLVATPlGHLLVDL 237 Thermofilum pen...
NP_148508    149 YELRFPEiFRTQSlvgGVDIFLVPAAWYRGPGKeeaLSVLSRARAQENTSYVAVASnaga-nfvGRSMIIHPlGYTLAQA 227 Aeropyrum perni...
YP_931348    142 FELRFPEvFRELAl-aGADLVAVPAAWYAGPLKeeiLHILARARAIENGMYIAVSAlwgp-rftGRSVVVNPfGVVEAEL 219 Pyrobaculum isl...
YP_002428414 155 YDLRFPElYRITAl-mGSEIIIVQAGWVKGPHKeeiLDKLASIRAHENTVYIVLADqtgd-mfvGRSGVFNPwGYRELDL 232 Desulfurococcus...
YP_001040235 155 YDLRFPElFRSYAr-kDAYGVFIHAGWVRGPLKeeiLDLLARARSHENTMYIILSDqtgk-qyvGRSGVFSPhGFREIDM 232 Staphylothermus...
Feature 1                                            
YP_997595    229 Aes------pALLIAALDPARIAHARrvLPVLANRR 258 Verminephrobacter eiseniae EF01-2
YP_001013827 234 Grg------eKIVQIEVDRESLEEARrqLPLLKLRR 263 Hyperthermus butylicus DSM 5456
ZP_02419514  233 Eag------eELIVLPVDTDQRDAIIhqVPVMKNRR 262 Anaerostipes caccae DSM 14662
ZP_04498584  229 RgsskgnapqDLVICTIDTDAVESARdaMPVLDHRR 264 Slackia heliotrinireducens DSM 20476
ZP_02440403  229 Gee-----keELLYAQIDKEQIQNIRtaNPVFENRR 259 Clostridium sp. SS2/1
YP_920633    238 Geg------eRSIAVDLDEGELASARerIPVRDLLR 267 Thermofilum pendens Hrk 5
NP_148508    228 Ppw------eWVLEHEIDLREIERARksLPVLEHVK 257 Aeropyrum pernix K1
YP_931348    220 Gag------eRYREVLIDLRLVEEARktVPTIYLRR 249 Pyrobaculum islandicum DSM 4184
YP_002428414 233 Gwr------eAYVEYTIDASLISEVRekLPVLQQSK 262 Desulfurococcus kamchatkensis 1221n
YP_001040235 233 Gyr------rGYVEWPINPDDVLEARkvVPVVEQSR 262 Staphylothermus marinus F1

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