Conserved Protein Domain Family
nitrilase_2

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cd07580: nitrilase_2 
Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143604
View PSSM: cd07580
Aligned: 13 rows
Threshold Bit Score: 347.411
Threshold Setting Gi: 118468846
Created: 8-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                 #                                      
YP_001757070  13 RVSCIQFEpef--gaVDANMARASDLVRAAAaegSRLIVLPELASTGYVFesaaeaaalaepvpdGPTTRAWAALAAEL- 89  Methylobacteriu...
NP_888091      6 KIAAIQFDvrq--geNDANRARSCELARQAAaagANLIVLPECCVGGLVFdsrdeir-avsetvpGPSTRAWSQVSRET- 81  Bordetella bron...
YP_889888      6 RVSAVTPDivi--gdLDGNLARLHNALRAIEwtgPYLAVLPELATSGYVFtdidea----ralslRADDARLTALADDVp 79  Mycobacterium s...
ZP_01129052    7 TVASCQVAlav--gdLAANRRSLRSAISEAAdagAQVVVLPELANTGYMFadigelr-slaepvdGLTVSEWVSLAGEH- 82  marine actinoba...
NP_250764      5 TVACCQIApri--gaQEHNLRLAERAIREAArrgANVVVLPELAASGYVFadrgeal-alaetrdGPSLGLWKALAGEL- 80  Pseudomonas aer...
ZP_03695951   30 RIAVAQTTpaf--geIERNREHTVELVREHAd--ADLLVLPELATSGYVFesesela-tmaeprdGATADAWADVAAET- 103 Natrialba magad...
YP_887306     13 RVAVVQFNpqvgvenLKANSEAVYERLQQAVaggANLIVLPELATTGYTFesreeayahaepvpsGATVTGWAEFAAAH- 91  Mycobacterium s...
CAY48411       9 RVAVIQLDpqvgmnnRANNLHQSLALATEAAnggANLIVLPELTNCGYFFssrqdafdhaelvpdGTSVQAWIDFACRH- 87  Pseudomonas flu...
ZP_01225867    8 QISCAQFEpri--geVERNVEASLKLIAEAAdsgSRLIVLPELCNSGYVLesreeayalsedvatGSSIARWASLAAER- 84  Aurantimonas sp...
ZP_03588263   10 KIACLQFSplf--gdVAGNLQRSIAMIEKAAdagARIVVLPELANTGYTFksraeafelaepvpdGRSTQAWAEVAACR- 86  Burkholderia mu...
YP_001893725   2 QIACVQMApri--geKDLNVRRAIDFVTRAAdlgAELVVLPELANTGYVFdsraeaeslaepvpdGSTTAAWSEVASAL- 78  Burkholderia ph...
YP_556518     15 VIACIQMEphv--gaKRDNVTRSIRHIETAAkngASLVILPELANTGYVFvdrdeafslaeelpdGQTARIFAEMARRL- 91  Burkholderia xe...
YP_002277969  12 TVATVQFEpiv--gdRAHNLAAIERLARAAKakgAEIVVLPELADSGYSFhdgdevaalagpvpgGLSAETLCRLAREL- 88  Rhizobium legum...
Feature 1                                                   #   #   #                         ## 
YP_001757070  90 -GVHIVAGIAESAGe---------ILYNAAVIVGPGGYIGTYRKAHLWd-QENVFFARGDlgfPVFDTalgKVGVAICYD 158 Methylobacteriu...
NP_888091     82 -GAWIVAGLSETDGa---------KIYNTAVLVGPNGELHRHRKLHVRg-IEQRLFDVGDa-lTCVDTplgRIGLAICYD 149 Bordetella bron...
YP_889888     80 aDCVAVVGFAEVDGd---------TLYNSAIVIGDGKVVGTYRKAHLWa-AEPEIFATGVeagTVIDTaicRLGVAICYD 149 Mycobacterium s...
ZP_01129052   83 -NLIIVGGFAEAGAd--------cEVFNSAVIVDASGVLACYRKAHLWntEKADLFTPGSgtpPVVDTavgRIGVMVCYD 153 marine actinoba...
NP_250764     81 -DLVIVGGFCERLDp--------qRVANSAALVDADGVRAIYRKAHLWn-EESGIFEAGEqppPVVATrfgRIAVMVCYD 150 Pseudomonas aer...
ZP_03695951  104 -DTWIVGGFPEAADvdtdttdansRYYNSALVVSPNGVEAVYRKLHLWn-EEHRWFTAGDe-lPVVGTpfgRLGVQICND 180 Natrialba magad...
YP_887306     92 -DVYIVGCLPELDGv---------ELFDTAVLVGPEGYIGKYRKTHLWn-EEKLFFSPGDlgyPVFHTrigRIGLLVCWD 160 Mycobacterium s...
CAY48411      88 -QVYLVAGLCEIDGm---------QLFNTAVLLGPDGFIGKYRKAHLWn-LEKLWFTPGNtgfPVFETpigRIGLLICWD 156 Pseudomonas flu...
ZP_01225867   85 -GLYIVAGFLERDGi---------KLYNSAIVIGPDGVIGTYRKNHLWa-DEALYFERGDlgfPVFHTpfgRVGVLICYD 153 Aurantimonas sp...
ZP_03588263   87 -NLIIVAGITEREDn---------CLYNSAVVLDPSGTLGTYRKLHLWg-DENLYFERGNlgvPVFATpygRIGVAICYD 155 Burkholderia mu...
YP_001893725  79 -GVYIVAGIAEKADg---------ALYNSAVLLGPDGYLGSYRKTHLWg-DEKKLFASGDrpsPIYDTplgRIAIAICYD 147 Burkholderia ph...
YP_556518     92 -GIHIVAGIAERAGt---------RLYNSAIFTGPSGHIGVYRKLHLWn-NERLFFEPGDfgiPVFDTsvgRIAIVICYD 160 Burkholderia xe...
YP_002277969  89 -CLYIVSGVAEQDGd---------RFYNSALLCGPDGYIGKYRKLHLWn-NENRLFRKGDiglPVFDLpfgRIGIAICYD 157 Rhizobium legum...
Feature 1        ##                    #                                                         
YP_001757070 159 GWFPEtFRRLAlaGAEIVCIPTNWvpmpdqp----egeaamANTLHRAAAHTNGIFIACADRVGIERGqpFEGQSLIIGP 234 Methylobacteriu...
NP_888091    150 MWFPEvCRNYAldGVDVVAAPANWsksvrtadafdayglpqGYHLMAATAVSNELVVVAADRVGTERGvaFLGTSCIFGP 229 Bordetella bron...
YP_889888    150 NEFPElPRRLAlrGAEVLALPVNWplvdrp-----egehapETIQAMAAARSSQLATVIADRRGTERGvrWTGGTAVIGP 224 Mycobacterium s...
ZP_01129052  154 LEFPEwVRTAAleGAELLCCPVNWplypap-----egerpiEVIKVQAAAATNRMFVAAADRAGIERGqdWLGGSVIVDA 228 marine actinoba...
NP_250764    151 LEFPEwVRLPAlsGAQLLCAPVNWpaaprp-----egerpaEVVRVQANASVNRLFIAACDRCGQERGvdWVGGSVIVDA 225 Pseudomonas aer...
ZP_03695951  181 LWFPElTVTQAkaGVDLVAVPTNWvpgpadgt--rpggwtiGAHQALAHANANRVFVACADRAGTERGvtFEGQSVILDP 258 Natrialba magad...
YP_887306    161 IWFPEtARIVAqqGADIICIPTGWvwtppply--ddsgtcmAAYLTMTAAHVNNVFIATADRIGTERTsgFMGNSLIAGT 238 Mycobacterium s...
CAY48411     157 IWFPEvPRILGqqGADIICSLNNWvwtppplf--deagkcmASYLTMTAAHVNNVFIAAASRIGEERGarYLGCSLIAGT 234 Pseudomonas flu...
ZP_01225867  154 GWFPEaWRILAlqGADIVCVPTNWvpmaeqp----agmpamANVLCMGAAHSNSMVVAACDRVGTERGqpFIGQSLIVDH 229 Aurantimonas sp...
ZP_03588263  156 GWFPEvFRLAAvqGADLMCVPTNWvpipgqq----pdqppmANILHMALAHSNSMVIACADRVGVERGqpFIGHSLIVGH 231 Burkholderia mu...
YP_001893725 148 LWFPElFRLYAlgGAQIVCVPTNWvpmpnqs----adrpamANTLAMAAAHTNGLVVACADRVGVERGqpFEGQSLVVDQ 223 Burkholderia ph...
YP_556518    161 GWFPEtYRLAAmqGADIVCVPTNWvpmssqp----ddrpamATTLTMAAAHSNGMAIACANRIGTERGqpFIGQSVIVGG 236 Burkholderia xe...
YP_002277969 158 GWFPEtFRELAlaGAELVCVPTNWvpmagae----siaepmANILHKAAAHTNGLYIACADRIGVERGqsFIGRSLIVGP 233 Rhizobium legum...
Feature 1                                                         
YP_001757070 235 kGWPLAGPAsrdrtETLSALVDLD--AAGRKDlnrf-nsllRDRRTDIY 280 Methylobacterium radiotolerans JCM 2831
NP_888091    230 sGEALCPAAsrgeeQILLADWPDI--AAVRAQggp----hlGQRQPAVY 272 Bordetella bronchiseptica RB50
YP_889888    225 dGWIKATPQgd--eTIATAVLDLTdsKAIGDRnd-----alADRRPDLY 266 Mycobacterium smegmatis str. MC2 155
ZP_01129052  229 dGFPLTTLDlg-vaSVHIAKLDLA--DARNKTisel-ndvhADRRPELY 273 marine actinobacterium PHSC20C1
NP_250764    226 dGYPLDGPLqg-eaGMLLARLDLA--EADEKRisah-nhvhRDRRPELY 270 Pseudomonas aeruginosa PAO1
ZP_03695951  259 nGLPLAGPApvdgeHALTTACDLT--RARNKEltpy-ddalASRRPEHY 304 Natrialba magadii ATCC 43099
YP_887306    239 nGWPIDRIAgpdedTILYADIDIT--ASRGAPiwnqfndlhRDRRTDLY 285 Mycobacterium smegmatis str. MC2 155
CAY48411     235 nGWPIGAVAsanrqEILFADIDVT--SARSAPiwnslndlqRDRRNDLY 281 Pseudomonas fluorescens SBW25
ZP_01225867  230 nGWPVAGPAsasepGLVTAICDLS--QARRKRnwndfnqvmRDRRTDLY 276 Aurantimonas sp. S185-9A1
ZP_03588263  232 tGWPVAGPAsgsdeEILIGEVSLS--AARRDRnwnsfnhplHDRRTDFY 278 Burkholderia multivorans CGD1
YP_001893725 224 sGWPVGDVAsrsleEIVSASITLD--ARTSVGthn---dvlADRRADIY 267 Burkholderia phytofirmans PsJN
YP_556518    237 dGWPITGPAsgdreEILYASIDLK--RTRSSRalnalnhvlHDRRADVY 283 Burkholderia xenovorans LB400
YP_002277969 234 qGWPISGPAsadreEILLAQIDLS--SVTETRtlnsfnhllGDRRADVY 280 Rhizobium leguminosarum bv. trifolii WSM2304

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