Conserved Protein Domain Family
nitrilase_1_R2

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cd07579: nitrilase_1_R2 
Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
Members of this subgroup have two nitrilase domains. This is the second of those two domains. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143603
View PSSM: cd07579
Aligned: 4 rows
Threshold Bit Score: 375.357
Threshold Setting Gi: 221636203
Created: 13-May-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                                       
YP_001190078 292 RVAVGQFTPaa-kQAGNLQRITELAVEAKae-gAELVVFPELALSGpyrgadma----eskdgagVSALLRLAQRLRLHL 365 Pseudomonas men...
YP_002524079 297 LIAVAQFLPkpgdLAANLATIDRSLAALPr--gTRLAVFPEYAATGvphdaseatafaasdtaslLRALRRLARRHRTAL 374 Thermomicrobium...
NP_947759    293 RLTAAQFAPtd-dIGGNLAQIDALARQAKan-gAEMVVFPELSLTGlddparta----vavpgpaTDRLAALASELSLYL 366 Rhodopseudomona...
NP_396472    296 RAAVAQFAPts-vIADNIAHITRLATEAKattaPDILVFPELSLTGlddphtra----eplsgpaVSVFVRLAMKLGLYL 370 Agrobacterium t...
Feature 1                                     #   #  #                         ## ##             
YP_001190078 366 VaGFVERdgealYNSAVLVGPEGvvGCYRKIHLNeQERAWATAGEc-wRHYDLpfgRIGLLIGEDCLVPEaGRVLAlrgC 444 Pseudomonas men...
YP_002524079 375 VvGFLEAlpggfASSAALVTPSGltVTYRKTHVIgPERSFLVPGDtppPVIDLplgRLGLLIGSDLCFPEiARVLAlagC 454 Thermomicrobium...
NP_947759    367 VcGLAERdgdilYNSAVLIAPDGtiTTYRKTHLTeNERGWAQPGDs-fVVCDTplgRVGLLIGHDAIFPEaGRVLAlrgC 445 Rhodopseudomona...
NP_396472    371 VaGFAEAdgdriYNSAVLAGPEGlvGNYRKTHLG-VADSWATAGDd-wKIYDLaigRVGLAIGHDALYPEaIRSLSlmgC 448 Agrobacterium t...
Feature 1               #                                                                        
YP_001190078 445 DLLACSTAlaeplpgahagsvirqnyPIPMGADPyHWHLGRVRAGENNVYLAFANsfdtdsgacGGSGVFGAd------- 517 Pseudomonas men...
YP_002524079 455 DLLAVPAGpgippvqalgptsvplppPAVTGDDPtHFHLARVRACENMTVVAYAAlplp--egtGWSGLFGPvpesrase 532 Thermomicrobium...
NP_947759    446 DIIACPAAietrfstphagtsvkqpaPIPTGADPhHWHHFRVRAGENNVFFAFANvadiargypGLSGVFGPd------- 518 Rhodopseudomona...
NP_396472    449 DLVACPSAiagnftgshagtkiphnyPIPKGADPfHWHALRVRGGENNVYFAFANvldaargyqGKSAVFGPd------- 521 Agrobacterium t...
Feature 1                                                             
YP_001190078 518 TFAFPRHEaiigdasGVAVASIDTSNLDARYPTNVVRRKDLVLMRQPLQYGAL 570 Pseudomonas mendocina ymp
YP_002524079 533 RLVEPGQA-------GLSWGLLDTRNAASRYPTNPLRAKDMLRMRQPYWYAPL 578 Thermomicrobium roseum DSM 5159
NP_947759    519 TFEFPRREalmgseeGIATATIDTSNLDSVYPTNVVRRKDLVAMRMPHSYRPL 571 Rhodopseudomonas palustris CGA009
NP_396472    522 SFAFPRQEsaildeeGIAAAAVDTTNLDTPYPTNIVRRKDLVVMRQPHHYQPL 574 Agrobacterium tumefaciens str. C58

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