Conserved Protein Domain Family
nitrilase_1_R1

?
cd07578: nitrilase_1_R1 
First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases)
Members of this subgroup have two nitrilase domains. This is the first of those two domains. The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
?
PSSM-Id: 143602
View PSSM: cd07578
Aligned: 4 rows
Threshold Bit Score: 459.69
Threshold Setting Gi: 221636203
Created: 1-Jun-2009
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                                       
NP_947759      5 LKVATVQFEPiMAEKERNIARLLELCEEAAvgGAKLIVTPEMGTTGYCWYDRAEVapfVEPIPGATTARFAELARKHDCY 84  Rhodopseudomona...
YP_001190078   6 VKIAAIQFEPvMGDKARNIERLSALVEEAAkaGAELIVTPEMATTGYCWMSREEIaahVETVPGATSAHFAELARRYDCY 85  Pseudomonas men...
YP_002524079   5 YRAAAIQFEPeLGAKEQNVERLLSLCTAAAraGARLLVTPEMATTGYCWYDRREIapfVEPIPGPTTERFATLAREHHCF 84  Thermomicrobium...
NP_396472      7 YTAAAIQFEPtMFEKARNISRLTALCEEAAqaGARLIVTPEMGTTGYCWFDRAEVkpfVETIPGPTTDVFHAIARQHRCY 86  Agrobacterium t...
Feature 1                                        #   #  #                         ## ##          
NP_947759     85 IVVGLPEVDE-DGIYYNSAVLIGPEGLIGRHRKTHPYiSEPKWSAAGDlhnQVFDTPIGRIALLICMDIHFVETARLMAL 163 Rhodopseudomona...
YP_001190078  86 IVIGLPEVDDdSGLYYNSAFLVGPQGLVGTHRKTHPYiAEPKWAAPGDrghQVFDTPIGRIALLICMDIHFLETARVAGL 165 Pseudomonas men...
YP_002524079  85 IVLGLPEVDSrTGIFYNAAALIGPSGVLGVYRKTHSFiSEPKWAKDGDlgfPVFSTELGRLGILICMDADYFEPARLLAL 164 Thermomicrobium...
NP_396472     87 IVVGMPEVDPeSDLYYNTAVLIGPDGVIGRHRKSHPYiAEPKWAANGDivhEVFETEIGRISMLVCMDLHFFETARLEAL 166 Agrobacterium t...
Feature 1                  #                                                                     
NP_947759    164 GGADIICHISNWlaertPAPYWISRAFENSCYVIESNRWGLERtVQFSGGSCVIAPdGSIAAVIDgGDGVAFAEIDLDtA 243 Rhodopseudomona...
YP_001190078 166 GGADVICHLSNWlaeraPAPYWINRAYENGCYLIEGNRWGLERgVQFSGGSCIVEPdGSIQASRDsGDGVVLGEMDLQhA 245 Pseudomonas men...
YP_002524079 165 QAADVLCFPTNWllekgPGATWIARAFENGCYLIAADRYGCERgVQFSGGSAIIEPdGTIQARLDsGDGYLLGEIELDrA 244 Thermomicrobium...
NP_396472    167 AGADIICHISNWlqertPAPYWINRAFENACYVIESNRWGLERtVQFSGGSCLIEPdGTVVASIDtGDGIAYGKVDLArA 246 Agrobacterium t...
Feature 1                             
NP_947759    244 RARQIGgea---vfRQRRPEL 261 Rhodopseudomonas palustris CGA009
YP_001190078 246 RQEQARr------mTLRRPER 260 Pseudomonas mendocina ymp
YP_002524079 245 RHKRFPgslapeklTARRPEF 265 Thermomicrobium roseum DSM 5159
NP_396472    247 RRREVLsep---vfKSRRPEL 264 Agrobacterium tumefaciens str. C58

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap