1J31,1J31


Conserved Protein Domain Family
Ph0642_like

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cd07577: Ph0642_like 
Click on image for an interactive view with Cn3D
Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases)
Uncharacterized subgroup of the nitrilase superfamily. This superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. Pyrococcus horikoshii Ph0642 is a hypothetical protein belonging to this subgroup. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). This subgroup was classified as belonging to class 13, which represents proteins that at the time were difficult to place in a distinct similarity group. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.
Statistics
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PSSM-Id: 143601
View PSSM: cd07577
Aligned: 14 rows
Threshold Bit Score: 409.381
Threshold Setting Gi: 124516252
Created: 28-Apr-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                               #                                        
1J31_A         3 KVGYIQXEPKILELDKNYSKAEKLIKEASkegAKLVVLPELFDTGYNFESREEVFDVAQqi-----peGETTTFLXELAR 77  Pyrococcus hori...
YP_001737386   3 RVGFVQTNPEFGAVESNLKRALDLASKVE---SDLLVFPELFNTGYLFLSREEALKLSEgl------dGPTIKRLSDFAS 73  Candidatus Kora...
YP_001521494   2 KVGFIQFSPILGKPTQTLERLEYLIDKGKh--SDILVLPELCNSGYAFNSRQQALNSSEsv-----adSKFIRFLHEKSN 74  Acaryochloris m...
YP_445637      4 RAAYLQFAPAYLEVDQNLAAVESLLRSVE---ADLIVLPELFTSGYFFQSKDDLERVAEpi-----pnGKSVAALRGWAD 75  Salinibacter ru...
YP_002247611   2 KVGYVQFRPKFGDKEYNVSKMIDMASTLD---AEVIVFPELANTGYVFKSKEEIVTLAEpy------dGPSIKRMQEFSK 72  Coprothermobact...
YP_001741047   2 KVSLLQFEPRLLDKEYNLKKMKQLLIGLK---TDLVVLPELCNSGYVFANKEEVFSVAEea-----gkGETYFVLNDIAN 73  Candidatus Cloa...
YP_001568665   3 KVSVVQFKPELFEIEKNVNKVMKIIEGVD---SNFIVFPELAFTGYAFSSKKEVEETYEspl---dgiGYAFKTFKEFSK 76  Petrotoga mobil...
EAY57760       4 RIVLVQNNPVFGEVAGNLDRVKALYGGRKglrPDLVIFPELFASGYQFTSKSEALSLGEgdgrdgrekGPTVRFLEEFSM 83  Leptospirillum ...
NP_661178      3 RLATVQFTPRLGERQANLEAIRSLLDPVE---ADIVVLPELCSSGYFFTSREELAPFAEsp------gGVACSFFQGLAD 73  Chlorobium tepi...
ZP_04424896    2 QVAYVQYNPAYLQITQNLKQVEALLEGIE---ADLIVLPELFASGYFFRSHEDLVAVAEpi-----peGPTTQWMIEWCR 73  Rhodothermus ma...
Feature 1                                            #   #  #                               ## ##
1J31_A        78 ELGLYIVAGTAEKSGnyLYNSAVVVGPRG-YIGKYRKIHLFYREKVFFEPGDl-GFKVFDIg-----fAKVGVXICFDWF 150 Pyrococcus hori...
YP_001737386  74 EHSTAIVAGFPERDGgkVYNSAVAIDIDGdVKGVYRKTHLFYEEKLIFDPGDt-GFRVFDLa-----gMRVGIMICFDWV 147 Candidatus Kora...
YP_001521494  75 KYNLYIVSGFCEKSDkdLYNSSFLVGPNE-YIEVYRKSHLFLNEKDFFSPGNt-DYSVYDIg-----iCKIGMLICFDWV 147 Acaryochloris m...
YP_445637     76 SLGATLVAGLAERDGdhFYNSAVVVRPDG-RVDTYRKVHLFYEETILFEAGDl-GFRVFEEhtaagtsYRLGVMVCFDWY 153 Salinibacter ru...
YP_002247611  73 RKGALLAFGFAERFGdvFYNSAAVVTPEG-EVKIYQKVHLFNEEKLYFNRGD--KFFTFTWh-----dTVFGVMICFDWI 144 Coprothermobact...
YP_001741047  74 SINCNIVYGYPELDGnnLFNSCMLIMPDG-RFYNYRKTHLFNREKLFFSPGDt-GFQVFTIln----gVKIGMMICFDWQ 147 Candidatus Cloa...
YP_001568665  77 DTGVSVVYGFNEKYEgkYYNSSILIKSDG-TYKIYRKTHLFFREKLFFTPGDt-GFWVDNIn-----gINVGVAICFDWY 149 Petrotoga mobil...
EAY57760      84 ETKGWVVGGLPLRRGnkVYNSAVVTHHGT-VMAIYDKTHLFEAENRWFERGSgpLCLVRTEf------GLMGVMICFDWL 156 Leptospirillum ...
NP_661178     74 AKRAIIIAGMPETAQgcFYNSVFVFRPGVaDPLVYRKSHLFYKERFVFEPGDtgFPVIRDEql----dISIGIMLCYDWR 149 Chlorobium tepi...
ZP_04424896   74 KTGTVMVGGLPERDGdrFYNSAVAVGPEG-LIGRYRKVHLFYEEKLHFSPGNl-GFQVFEVadrngqlYRLGVMICFDWY 151 Rhodothermus ma...
Feature 1                            # ##   #                                                    
1J31_A       151 FPESARTLALKGAEIIAHPANLVXP-YAPRAXPIRALENRVYTITADRVGee-----rgLKFIGKSLIASPKAEVLSIAS 224 Pyrococcus hori...
YP_001737386 148 FPESARSLALSGAQIIAHPSCLVMP-YAPKADPVRAFENRVFIILSDRSGveer-ggkkLRYHGMSLISDPKMNILTQAP 225 Candidatus Kora...
YP_001521494 148 FPEAWRILALKGADIICHPSNIVLPdLCQKTIPGHSICNRMFIVTANRIGte-----dnLTFTGSSIICDPRGNILTQAS 222 Acaryochloris m...
YP_445637    154 FPEAARTLALRGADVIAHPSNLVLP-HCPDSMPVRARENHVFTITANRHGreek-egesLRFIGMSEVCAPSGTILTRAD 231 Salinibacter ru...
YP_002247611 145 FPEAMRTLALMGAQIVLHPANLVLP-YCQDAMVTRCIENRVFEITANRIGve-----rgLKFTGASQITAPGGIVLHRAT 218 Coprothermobact...
YP_001741047 148 FPEAARTLALLGAQIICHPANLVLP-WCQQAMKTRCLENRVFAVTANRIGtein-ageiFNFTGQSQILNTRGEVLSSLS 225 Candidatus Cloa...
YP_001568665 150 FPESFRTLALLGADLILHPANLVLP-YCQEANKIRSLENKIYIATSNIWGtqin-geieYSFTGKSQVTSPDGEVLFRLP 227 Petrotoga mobil...
EAY57760     157 FPEVTRSLALSGALLIAHPVNWVLP-FGPQGMILRSVENRVFTATANRVGeearggfkpLRYIGSSQVVSPQGEILARAP 235 Leptospirillum ...
NP_661178    150 FPEVSRVLALGGADLIACPSNLVTD-AWRKVMPARAIENKLYVAVANRCGtetr-gdetLLFKGCSAVYDPYGETVALAD 227 Chlorobium tepi...
ZP_04424896  152 FPEAARTLALQGADVIAHPSNLVRP-DCPRAMPIRALENHVFTITANRYGvesn-gretLRFIGRSLICDPAGRVLQEAP 229 Rhodothermus ma...
Feature 1                                            
1J31_A       225 eteeEIGVVEIDLNLARNKRLNDXNDIFKDRREEYY 260 Pyrococcus horikoshii
YP_001737386 226 eegeHVGIAEIDPKLAEDKRVNELNDIFLDRRPEFY 261 Candidatus Korarchaeum cryptofilum OPF8
YP_001521494 223 ddqeEVMISDIDLNLARDKSITSRNHIFLDRRPDKY 258 Acaryochloris marina MBIC11017
YP_445637    232 esadVVEVVELNPREARDRNINAHNDVLRDRRPATY 267 Salinibacter ruber DSM 13855
YP_002247611 219 ktkeEALAVDIDPGLALQKSINSYNDLFKDRLPSAY 254 Coprothermobacter proteolyticus DSM 5265
YP_001741047 226 vseeGTITVEINPEEANDKTVTERNDAFKDRRPEFY 261 Candidatus Cloacamonas acidaminovorans
YP_001568665 228 eqgdFIQTAEIDERKSQNKRINEYNDLFQDRKPKYY 263 Petrotoga mobilis SJ95
EAY57760     236 eeaeSLLEIQCDPELARSKRVVEESDFFRQRRPDLY 271 Leptospirillum sp. Group II UBA
NP_661178    228 adndRVLLAEIDPRSCRDKSFNEFNDIFADRRPELY 263 Chlorobium tepidum TLS
ZP_04424896  230 pegdQVGIAEITPREARNRRITPHNDLFEDRRPDCY 265 Rhodothermus marinus DSM 4252

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